Results 101 to 110 of about 48,956 (312)

Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking

The Journal of Headache and Pain, 2019
Background Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches.
Raffi Manoukian, Hong Sun, Silke Miller, Di Shi, Brian Chan, Cen Xu   +5 more
doaj   +1 more source

Phosphatidylinositol‐4,5‐bisphosphate 3‐kinase (PI3K) inhibitors reduce vascular inflammation in vitro and in vivo

British Journal of Pharmacology, EarlyView.
Background and Purpose Endothelial cells play central roles in increasing vascular permeability and leukocyte recruitment. Therapeutic approaches for treating endothelial cell barrier dysfunction to reduce unwanted fluid accumulation in tissues are limited.
Hiba Chaudhry, Ali A. Zarban, Silvia Cellone Trevelin, Xenia Kodji, Camilla Cerutti, Xiaoqing Xiong, Fulye Argunhan, Ajay M. Shah, Anne J. Ridley, Susan D. Brain   +9 more
wiley   +1 more source

TRPA1 ion channel activation context‐dependently regulates gene expression in normal and psoriatic human skin

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Psoriasis is a chronic, relapsing, immune‐mediated inflammatory skin disease. The transient receptor potential ankyrin 1 (TRPA1) ion channel plays a protective role in the formation of psoriasiform skin reactions. Here, we investigated the pharmacological activation and blockade of TRPA1 in human skin (patho)physiology ...
Ágnes Kemény, Szabina Horváth, Júlia Szebényi, Péter Oláh, Viktória Németh, Péter Urbán, József Kun, Attila Gyenesei, Areej Jaber, Erika Pintér, Rolland Gyulai   +10 more
wiley   +1 more source

The Role of Asiatic Acid in Preventing Dental Pulp Inflammation: An in-vivo Study

Clinical, Cosmetic and Investigational Dentistry, 2023
Arlina Nurhapsari,1,2 Risya Cilmiaty,3 Adi Prayitno,3 Bambang Purwanto,4 Soetrisno Soetrisno5 1Doctoral Degree of Medical Science, Faculty of Medicine, Sebelas Maret University, Surakarta, Central Java, Indonesia; 2Department of Conservative Dentistry ...
Nurhapsari A, Cilmiaty R, Prayitno A, Purwanto B, Soetrisno S   +4 more
doaj  

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence [PDF]

, 1996
Enteric and sympathetic neurons have previously been proposed to be lineally related. We present independent lines of evidence that suggest that enteric neurons arise from at least two lineages, only one of which expresses markers in common with ...
Anderson, D. J., Blaugrund, E., Gershon, M. D., Lo, L., Pham, T. D., Sommer, L., Tennyson, V. M.   +6 more
core  

Optochemical modulation of corneal cold nerve terminal impulse activity with a photochromic ion channel blocker

British Journal of Pharmacology, EarlyView.
Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez, Almudena Iñigo‐Portugués, Enrique Velasco, Susana Quirce, Fernando Aleixandre‐Carrera, Ariadna Díaz‐Tahoces, M. Carmen Acosta, Wan‐Chen Lin, Richard H. Kramer, Carlos Belmonte, Juana Gallar, Victor Meseguer   +11 more
wiley   +1 more source

Endothelium and the vasodilator action of rat calcitonin gene‐related peptide (CGRP) [PDF]

, 1987
Geoffrey C. Grace, G. J. Dusting, Bruce E. Kemp, T. John Martin   +3 more
openalex   +1 more source

CGRP and the Trigeminal System in Migraine

Headache: The Journal of Head and Face Pain, 2019
ObjectiveThe goal of this narrative review is to provide an overview of migraine pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) within the context of the trigeminovascular system.BackgroundMigraine is a prevalent and disabling neurological disease that is characterized in part by intense, throbbing, and ...
Michael H. Ossipov, Smriti Iyengar, Kirk W. Johnson, Sheena K. Aurora   +3 more
openaire   +2 more sources

Efficacy and Safety of Rimegepant 75 Mg Oral Tablet, a CGRP Receptor Antagonist, for the Acute Treatment of Migraine: A Randomized, Double-Blind, Placebo-Controlled Trial [Corrigendum]

Journal of Pain Research
Lipton RB, Thiry A, Morris BA, Croop R. J Pain Res. 2024 Jul 22:17:2431–2441. The authors have advised that Figure 2 on page 2437 is incorrect. The text “150/241 (27.7%)” in the Placebo n/N (Risk) column for the row Freedom from MBS ...
Lipton RB, Thiry A, Morris BA, Croop R
doaj