Results 151 to 160 of about 43,468 (306)
Therapeutic advances in pruritus as a model of personalized medicine
Journal of the European Academy of Dermatology and Venereology, EarlyView.Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung +2 more
wiley +1 more source
Elucidating the Ability of CGRP to Modulate Microvascular Events in Mouse Skin [PDF]
, 2022 Ali A. Zarban +5 more
openalex +1 more source
Inflammatory niches as spatial drivers of disease mechanisms and targets for personalized treatment
Journal of the European Academy of Dermatology and Venereology, EarlyView.This study provides a comprehensive review of how spatial transcriptomics reveals disease‐specific inflammatory niches across multiple skin disorders, highlighting key immune–stromal, neuro–immune and metabolic interactions that were previously unappreciated in non‐spatial analyses. Abstract Disease states are increasingly recognized as being shaped by
Rundong Jiang +3 more
wiley +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.
Shigekazu Kitamura +11 more
wiley +1 more source
Journal of Anatomy, EarlyView.Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou +6 more
wiley +1 more source
Understanding side-effects of anti-CGRP and anti-CGRP receptor antibodies [PDF]
The Journal of Headache and Pain, 2020 Haanes, Kristian Agmund +2 more
openaire +5 more sources
Journal of Oral Rehabilitation, EarlyView.DC/TMD: Diagnostic Criteria for Temporomandibular Disorders; RDC/TMD: Research Diagnostic Criteria for Temporomandibular Disorders; ICHD: International Classification of Headache Disorders. OR: Odds Ratio. ABSTRACT Background Migraine and temporomandibular disorders (TMD) are comorbid conditions that are highly frequent among patients.
Marlon Ferreira Dias +4 more
wiley +1 more source
Structure and methylation of the human calcitonin/α-CGRP gene
, 1989 P.M. Broad +3 more
openalex +2 more sources
Inflammatory and Immunological Basis of Periodontal Diseases
Journal of Periodontal Research, EarlyView.The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima +3 more
wiley +1 more source
Parabrachial CGRP Neurons Control Meal Termination [PDF]
, 2016 Carlos Campos +3 more
openalex +1 more source