Results 81 to 90 of about 3,615 (181)

Pathogenic mycobacterium upregulates cholesterol 25-hydroxylase to promote granuloma development via foam cell formation

iScience
Summary: Pathogenic mycobacteria orchestrate the complex cell populations known as granuloma that is the hallmark of tuberculosis. Foam cells, a lipid-rich cell-type, are considered critical for granuloma formation; however, the causative factor in foam ...
Shuang Zhou, Ding Zhang, Dan Li, Hankun Wang, Cairong Ding, Jingrui Song, Weifeng Huang, Xuan Xia, Ziwei Zhou, Shanshan Han, Zhu Jin, Bo Yan, Jacqueline Gonzales, Laura E. Via, Lu Zhang, Decheng Wang   +15 more
doaj   +1 more source

Unique genome-wide transcriptome profiles of chicken macrophages exposed to Salmonella-derived endotoxin [PDF]

, 2010
Background Macrophages play essential roles in both innate and adaptive immune responses. Bacteria require endotoxin, a complex lipopolysaccharide, for outer membrane permeability and the host interprets endotoxin as a signal to initiate an innate immune
Ceren Ciraci, Christopher K Tuggle, Michael J Wannemuehler, Dan Nettleton, Susan J Lamont   +4 more
core   +2 more sources

IL-1β/TNF-α/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in Zika virus–infected human macrophages [PDF]

Journal of Biological Chemistry, 2019
Zika virus (ZIKV)3 is an enveloped, single-stranded, positive-sense RNA virus of the Flaviviridae family that has emerged as a public health threat because of its global transmission and link to microcephaly. Currently there is no vaccine for this virus.
Tshifhiwa Magoro, Aditya Dandekar, Lucas T. Jennelle, Rohan Bajaj, Gabriel Lipkowitz, Angelina R. Angelucci, Pascal O. Bessong, Young S. Hahn   +7 more
openaire   +2 more sources

The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism [PDF]

, 2017
Macrophages exert potent effector functions against invading microorganisms but constitute, paradoxically, a preferential niche for many bacterial strains to replicate.
Beceiro, S, Bresque, M, Caelles, C, Carbó, JM, Castrillo, A, Chini, EN, Escande, C, Glaria, E, Juarez, A, Kiefer, K, León, TE, Lindbom, L, Matalonga, J, Morón-Ros, S, Pascual-García, M, Paytubi, S, Riera, A, Sancho, J, Sanjurjo, L, Sarrias, M-R, Serret, J, Sotillo, F, Valledor, AF, Vicente, R   +23 more
core  

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles [PDF]

, 2019
Tumor-derived extracellular vesicles (TEV) “educate” healthy cells to promote metastases. We found that melanoma TEV downregulated type I interferon (IFN) receptor and expression of IFN-inducible cholesterol 25-hydroxylase (CH25H).
Antrobus, R, Bhattacharya, S, Brice, AK, Carbone, CJ, Cho, C, Diehl, JA, Fuchs, SY, Gui, J, Guo, W, Haas, V, Handa, S, Katlinskaya, YV, Katlinski, KV, Kirkwood, JM, Koumenis, C, Lehner, PJ, Ludwig, S, Matheson, NJ, Minn, AJ, Ortiz, A, Rui, H, Sander, C, Tarhini, AA, Volk, SW, Wals, K, Whiteside, TL, Yu, P, Yu, Q, Zahedi, F   +28 more
core   +1 more source

Additional file 1 of Curcumol inhibits EMCV replication by activating CH25H and inhibiting the formation of ROs

, 2023
Additional file 1: Supplementary Figure 1. Curcumol activates CH25H via JAK/STAT signaling pathway. Three concentrations of curcumol (0.025, 0.0125 and 0.00625 mg/mL) and ribavirin (0.25 mg/mL) were selected to treat EMCV-infected HEK-293T cells for 24 h, and the expression of JAK1, STAT2, P-STAT2, IRF9 and CH25H protein were detected by Western blot ...
Zheng, Jiangang, Sun, Panpan, Sun, Na, Hao, Zhili, Fan, Kuohai, Yin, Wei, Khan, Ajab, Guo, Jianhua, Zheng, Xiaozhong, Li, Hongquan   +9 more
openaire   +1 more source

Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide

Journal of Lipid Research, 2009
During screening of genes upregulated by lipopolysaccharide (LPS; endotoxin) treatment of bone marrow-derived mouse macrophages, it was unexpectedly found that cholesterol 25-hydroxylase (Ch25h) was strongly upregulated.
Ulf Diczfalusy, Katarina E. Olofsson, Ann-Margreth Carlsson, Mei Gong, Douglas T. Golenbock, Olav Rooyackers, Urban Fläring, Harry Björkbacka   +7 more
doaj   +1 more source

Treatment of Inborn Errors by Product Replacement: The Example of Inborn Errors of Bile Acid Synthesis

Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT Many inborn errors of metabolism affect pathways involved in the synthesis of a metabolite that has an important biochemical or physiological function, and adverse effects of the disorder can be attributed to the lack of this metabolite. Thus, there is the opportunity for treatment by ‘product replacement’. One of the disorders in the pathways
Peter T. Clayton, Rohit Hirachan, Elaine Murphy   +2 more
wiley   +1 more source

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, Volume 5, Issue 9, September 2025.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer. [PDF]

, 2013
The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical behaviour and response to therapy translates into an urgent need for robust molecular disease subclassifiers that can explain this heterogeneity beyond current ...
Bosman, F., Budinska, E., D'Ario, G., Delorenzi, M., Di Narzo, A.F., Hodgson, J.G., Lapique, N., Popovici, V., Roth, A., Sikora, K.O., Tejpar, S., Weinrich, S., Yan, P.   +12 more
core   +2 more sources