Results 61 to 70 of about 2,414 (116)

25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation

Journal of Neuroinflammation
Neuroinflammation has been implicated in the pathogenesis of several neurologic and psychiatric disorders. Microglia are key drivers of neuroinflammation and, in response to different inflammatory stimuli, overexpress a proinflammatory signature of genes.
Johnathan Romero, Danira Toral-Rios, Jinsheng Yu, Steven M. Paul, Anil G. Cashikar   +4 more
doaj   +1 more source

Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry

Frontiers in Immunology, 2019
Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-induced gene that catalyzes the oxidation of cholesterol to 25-hydroxycholesterol (25HC), which exerts broad-spectrum antiviral function.
Ya Zhang, Liqun Wang, Liqun Wang, Xiaohong Huang, Shaowen Wang, Youhua Huang, Qiwei Qin, Qiwei Qin   +7 more
doaj   +1 more source

Cholesterol 25‐Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4

Advanced Science
Cholesterol 25‐hydroxylase (CH25H), an enzyme involved in cholesterol metabolism, regulates inflammatory responses and lipid metabolism. However, its role in kidney disease is not known.
Lu Zhang, Zhengying Fang, Qingqing Zhu, Shumin Yang, Jia Fu, Zeguo Sun, Geming Lu, Chengguo Wei, Zhi Zhang, Kyung Lee, Yifei Zhong, Ruijie Liu, John Cijiang He   +12 more
doaj   +1 more source

25-hydroxycholesterol aggravates oxygen-glucose deprivation/reoxygenation-induced pyroptosis through promoting activation of NLRP3 inflammasome in H9C2 cardiomyocytes

Brazilian Journal of Medical and Biological Research
25-hydroxycholesterol (25-HC) plays a role in the regulation of cell survival and immunity. However, the effect of 25-HC on myocardial ischemia/reperfusion (MI/R) injury remains unknown.
Tao Jiang, Yong Li
doaj   +1 more source

Oxysterols contribute to immune cell recruitment in SLE skin lesions

Arthritis Research & Therapy
Background Abnormal oxysterol metabolism has been observed in the peripheral blood of SLE patients, but its role in systemic lupus erythematosus (SLE) skin lesions remains unclear.
Xiaoyun Chen, Lianlian Ouyang, Sujie Jia, Ming Zhao   +3 more
doaj   +1 more source

Identification of marker genes for spinal cord injury

Frontiers in Medicine
IntroductionSpinal cord injury (SCI) is a profoundly disabling and devastating neurological condition, significantly impacting patients’ quality of life.
Zhiwei Luan, Zhiwei Luan, Jiayu Zhang, Yansong Wang, Yansong Wang, Yansong Wang   +5 more
doaj   +1 more source

ISEV2025 Abstract Book

Journal of Extracellular Vesicles, Volume 14, Issue S1, October 2025.
wiley   +1 more source

Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice

Nature Communications
Cancer cells secrete extracellular vesicles (EV) encapsulating bioactive cargoes to facilitate inter-organ communication in vivo and are emerging as critical mediators of tumor progression and metastasis, a condition which is often accompanied by a ...
Mei-Xin Li, Sheng Hu, He-Hua Lei, Meng Yuan, Xu Li, Wen-Kui Hou, Xiang-Jie Huang, Bing-Wen Xiao, Teng-Xiang Yu, Xiao-Hui Zhang, Xiao-Ting Wu, Wen-Qiang Jing, Hyeon-Jeong Lee, Juan-Juan Li, Da Fu, Li-Min Zhang, Wei Yan   +16 more
doaj   +1 more source

CH25H-mediated cholesterol metabolism drives chondrogenic differentiation in adipose-derived stem cells and enhances cartilage repair. [PDF]

Commun Biol
Wang Y, Ye W, Chen Y, Zhuang Y, Qin Z, Luo D, Ren Z, Yang Z.   +7 more
europepmc   +1 more source

25HC regulates the polarization of CD163⁺ macrophages in the immune microenvironment of triple-negative breast cancer through the interferon pathway. [PDF]

Front Immunol
Zheng H, Huang W, Zhang P, Bhushan S, Wu X, Yang Y.   +5 more
europepmc   +1 more source