Results 91 to 100 of about 93,229 (254)

Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase [PDF]

, 2017
Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics.
Gallant, Joseph P.
core   +1 more source

Evidence of internal structure validity of the nursing outcome “Mechanical Ventilation Weaning Response: Adult (0412)” for critically ill COVID‐19 patients

International Journal of Nursing Knowledge, EarlyView.
Abstract Purpose To evaluate the evidence of internal structure validity of the nursing outcome (NO) “Mechanical Ventilation Weaning Response: Adult (0412)” of the NOs classification for critically ill COVID‐19 patients. Methods A methodological study focused on internal structural validation, part of a multicenter study, was carried out in the ...
Aline Batista Maurício, Viviane Martins da Silva, Agueda Maria Ruiz Zimmer Cavalcante, Larissa Giardini Bruni, Sue Ann Moorhead, Elizabeth Swanson, Karen Dunn Lopez, Marcos Venícios de Oliveira Lopes, Alba Lucia Bottura Leite de Barros   +8 more
wiley   +1 more source

Health literacy & Chagas disease knowledge: A cross-sectional study in Southern Loja Province, Ecuador

PEC Innovation
Objective: Health literacy is associated with many patient outcomes. This study sought to determine the association between a person's level of health literacy and their knowledge about Chagas disease. Methods: A cross-sectional survey was conducted with
Talia L. Caridi, Fernanda Mariño-Polo, Cora G. Farra, Alison M. Mingus, Athar Memon, Mario J. Grijalva, Benjamin R. Bates   +6 more
doaj   +1 more source

Unraveling the Differences of the Hydrolytic Activity of Trypanosoma cruzi trans-Sialidase and Trypanosoma rangeli Sialidase: A Quantum Mechanics–Molecular Mechanics Modeling Study [PDF]

, 2014
Chagas’ disease, also known as American trypanosomiasis, is a lethal, chronic disease that currently affects more than 10 million people in Central and South America. The trans-sialidase from Trypanosoma cruzi (T. cruzi, TcTS) is a crucial enzyme for the
Bueren Calabuig, Juan A., Pierdominici Sottile, Gustavo, Roitberg, Adrián   +2 more
core   +1 more source

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Hospitalizations due to stroke and their relationship with Chagas disease: a population-based analytical study using data from the Hospital Information System of the Brazilian National Health System, Minas Gerais, Brazil, 2022

Epidemiologia e Serviços de Saúde
Objective To assess whether hospitalizations due to stroke were associated with Chagas disease and the Chagas disease vulnerability index in the state of Minas Gerais. Methods This was a population-based analytical observational study.
Ana Clara de Jesus Santos, Nayara Dornela Quintino, Jeniffer Eduarda Firmino Almeida Silva, Maria do Carmo Pereira Nunes, João Alves Pereira, Ester Cerdeira Sabino, Ariela Ferreira Mota, Desirée Sant'Ana Haikal   +7 more
doaj   +2 more sources

Enfermedad de Chagas Chagas disease

Revista Colombiana de Cardiología, 2011
Fernando Rosas A
doaj   +1 more source

Mortality Related to Chagas Disease and HIV/AIDS Coinfection in Brazil

Journal of Tropical Medicine, 2012
Chagas disease in patients with HIV infection represents a potentially serious event with high case fatality rates. This study describes epidemiological and clinical aspects of deaths related to Chagas disease and HIV/AIDS coinfection in Brazil, 1999 ...
Francisco Rogerlândio Martins-Melo, Alberto Novaes Ramos, Carlos Henrique Alencar, Jorg Heukelbach   +3 more
doaj   +1 more source

Risks of endemicity, morbidity and perspectives regarding the control of Chagas disease in the Amazon Region

Memorias do Instituto Oswaldo Cruz, 2012
Chagas disease, in the Amazon Region as elsewhere, can be considered an enzootic disease of wild animals or an anthropozoonosis, an accidental disease of humans that is acquired when humans penetrate a wild ecosystem or when wild triatomines invade human
José Rodrigues Coura, Angela CV Junqueira   +1 more
doaj   +1 more source

In the Spotlight—Established Researcher

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Rodrigo Nunes‐da‐Fonseca
wiley   +1 more source