Results 111 to 120 of about 93,229 (254)

Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial

Memorias do Instituto Oswaldo Cruz
Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic Chagas disease, and is one of the leading causes of morbidity and death in Latin America.
Anis Rassi Jr, José Antonio Marin Neto, Anis Rassi   +2 more
doaj   +1 more source

Repurposing of terconazole as an anti Trypanosoma cruzi agent [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. Currently there are no effective treatments for the chronic phase of the disease, when most patients are diagnosed, therefore the development of ...
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Reigada, Chantal, Valera Vera, Edward Augusto   +4 more
core   +1 more source

Multidimensional associations of physical performance, balance, wellness and daily activities with frailty in older adults with coexisting frailty and diabetes

Journal of Clinical Nursing, EarlyView.
Abstract Background The coexistence of frailty and type 2 diabetes mellitus in the older population heightens the risk of adverse events. However, research on functional and wellness factors associated with frailty in this population is limited. Purpose To investigate the associations of physical performance, functional dependency, physical activity ...
Juan Corral‐Pérez, Alba Mier, María Ángeles Vázquez‐Sánchez, María Naranjo‐Márquez, Jesus Gustavo Ponce‐Gonzalez, Cristina Casals   +5 more
wiley   +1 more source

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Phanstiel, Otto, Reigada, Chantal, Valera Vera, Edward Augusto   +5 more
core   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, EarlyView.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model [PDF]

, 2016
Chronic obesity and Chagas disease (caused by the protozoan Trypanosoma cruzi) represent serious public health concerns. The interrelation between parasite infection, adipose tissue, immune system and metabolism in an obesogenic context, has not been ...
Andrada, Marta Cecilia, Aoki, Maria del Pilar, Cabalén, María Eugenia, Cabral, Maria Fernanda, Cano, Roxana Carolina, Gea, Susana, Onofrio, Luisina Inés, Ponce, Nicolás Eric, Sanmarco, Liliana Maria   +8 more
core   +4 more sources

Changes in the Pterygopalatine and Midpalatal Sutures After Rapid Palatal Expansion With Tooth‐Bone‐Borne (MARPE) and Tooth‐Borne (Hyrax) Appliances

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Objective This retrospective cohort study aimed to compare the effects of tooth‐bone‐borne mini‐implant‐assisted rapid palatal expansion (MARPE) and tooth‐borne (Hyrax) rapid palatal expansion (RPE) techniques on the pterygopalatine suture (PPS) and the opening pattern of the midpalatal suture (MPS).
Maria Antônia Netto Barbosa, Luciana Quintanilha Pires Fernandes, Giselle Naback Lemes Vilani, Jonas Capelli Júnior   +3 more
wiley   +1 more source

Perceptions of Hansen's Disease in Northeast Brazil: A Community‐Based Study Integrating Stigma, Empowerment, and Social Distance

Tropical Medicine &International Health, EarlyView.
ABSTRACT Perceptions of Hansen’s disease (HD) can influence the level of stigma, empowerment, and intention to distance oneself from those affected by the disease. Knowledge, attitudes, and beliefs shape these perceptions. This study aims to understand perceptions of HD regarding stigma and empowerment. Method: A cross‐sectional, mixed‐methods research
Jaqueline Caracas Barbosa, Aymée Medeiros da Rocha, Hellen Xavier Oliveira, Nágila Nathaly Lima Ferreira, Adriana da Silva dos Reis, Anderson Fuentes Ferreira, Wim H. van Brakel, Anna T. van ‘t Noordende, Duane Charles Hinders, José Alexandre Menezes da Silva, Carmem Emmanuely Leitão Araújo, Rômulo do Nascimento Rocha, Alberto Novaes Ramos Jr   +12 more
wiley   +1 more source

Persistent and Emerging High‐Risk Clusters of Leprosy Detection in Brazil: A Nationwide Spatiotemporal Analysis, 2001–2023

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background Brazil accounts for a substantial share of the global leprosy burden, with persistent high‐risk areas and marked spatial inequalities in case detection. Identifying spatiotemporal clusters of transmission is crucial for targeting surveillance and control efforts.
Anderson Fuentes Ferreira, Jorg Heukelbach, Eliana Amorim de Souza, Carmelita Ribeiro Filha Coriolano, Elaine Silva Nascimento Andrade, Aymée Medeiros da Rocha, José Alexandre Menezes da Silva, Carlos Dornels Freire de Souza, Juliana Maria Cavalcante Ribeiro Ramos, Alberto Novaes Ramos Jr   +9 more
wiley   +1 more source

Variants in Genes Encoding Innate Lymphoid Cells Type 2 Surface Markers Affecting Asthma and Atopy Pathologies

Clinical &Experimental Allergy, EarlyView.
Raphael Chagas Silva, Gabriela Pimentel Pinheiro, Hátilla dos Santos Silva, Talita dos Santos de Jesus, Carolina Melo Orrico‐Ferreira, Jamille Souza Fernandes Chiarelotto, Cinthia Vila Nova Santana, Carina da Silva Pinheiro, Ricardo Riccio Oliveira, Álvaro Augusto Cruz, Kathleen C. Barnes, Neuza Maria A. Neves, Ryan dos Santos Costa, Camila Alexandrina Figueiredo   +13 more
wiley   +1 more source