Results 41 to 50 of about 104,274 (271)

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Age-Standardized Mortality Rates Related to Cirrhosis in Brazil from 2000 to 2012: A Nationwide Analysis

Annals of Hepatology, 2017
Background Cirrhosis remains the most frequent liver-related cause of death worldwide and we aimed to evaluate its burden in Brazil from 2000 to 2012.Material and methods The Brazilian National Death Registry was analyzed from 2000 to 2012.
Hugo Perazzo, Antonio G. Pacheco, Raquel De Boni, Paula M. Luz, Juliana Fittipaldi, Sandra W. Cardoso, Beatriz Grinsztejn, Valdiléa G. Veloso   +7 more
doaj   +1 more source

A Multiepitope‐Based Lateral Flow Assay for Leprosy Antibodies

Analysis &Sensing, EarlyView.
An innovative lateral flow assay for leprosy diagnosis is based on gold nanoparticles and synthetic Mycobacterium leprae epitopes conjugated to keyhole limpet hemocyanin protein to enhance antibody detection. This strategy provides a rapid, accurate, and low‐cost approach for resource‐limited settings, enabling the early detection of infection. Leprosy
Cristiane Zocatelli‐Ribeiro, Camila dos Anjos Proença, Ana Carolina da Rosa Nogarolli, Ana Fabiele Domakoski Trevisan, Thiago Neves Machado, João Carlos Degraf Muzzi, Larissa Magalhães Alvarenga, Juliana de Moura   +7 more
wiley   +1 more source

Chagas Disease and Heart Failure: An Expanding Issue Worldwide

European Cardiology Review, 2019
Chagas disease, originally a South American endemic health problem, is expanding worldwide because of people migration. Its main impact is on the cardiovascular system, producing myocardial damage that frequently results in heart failure.
Felipe Martinez, Eduardo Perna, Sergio V Perrone, Alvaro Sosa Liprandi   +3 more
doaj   +1 more source

Surfactant‐Enhanced Electrospun Nanofiber Filters for Efficient Viral and Bacterial Inactivation

Journal of Applied Polymer Science, EarlyView.
In this work, electrospun polyacrylonitrile (PAN) nanofibrous filters functionalized with surfactants (CTAB, CPC, and SDS) were developed for air filtration applications. The PAN nanofiber mats enable efficient particulate matter capture while simultaneously providing antimicrobial and antiviral activity against bacteria (E. coli and S.
Edilton N. da Silva, Paulo A. M. Chagas, Gustavo C. da Mata, Felipe A. Lima, Fabiana B. Furtado, Wanderley P. de Oliveira, Rejane M. T. Grotto, Clovis W. O. de Souza, Mônica L. Aguiar, Vádila G. Guerra   +9 more
wiley   +1 more source

CrAg screening strategy reduces definitive sequelae in people living with HIV

Discover Viruses
Background Screenning cryptococcal antigen (CrAg) of people living with HIV (PLHIV) reduces the morbidity and development of cryptococcal meningitis, but recent publications shows that it does not reduce mortality when comparable with a negative CrAg ...
Marcela de Faria Ferreira, Fabio Brito-Santos, Marcos de Abreu Almeida, Luciana Trilles, Marcia dos Santos Lazera   +4 more
doaj   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Physical activity levels during COVID-19 pandemic and its associated factors in patients with Chagas disease

Frontiers in Medicine
BackgroundA better understanding of the consequences of the Coronavirus Disease 2019 (COVID-19) pandemic on lifestyle of patients with Chagas disease (ChD) is of paramount importance to facilitate the implementation of intervention strategies tailored to
Isis Gabrielli Gomes Xavier, Patrícia Mello Andrade, Rodrigo de Lima Vitor, Tayná Cruz Barros, Luciana Fernandes Portela, Marcelo Teixeira de Holanda, Luiz Henrique Conde Sangenis, Gilberto Marcelo Sperandio da Silva, Flavia Mazzoli-Rocha, Fernanda de Souza Nogueira Sardinha Mendes, Andréa Rodrigues da Costa, Marcel de Souza Borges Quintana, Alejandro Marcel Hasslocher-Moreno, Itauá Leston Araujo, Angela Cristina Verissimo Junqueira, Roberta Olmo Pinheiro, Ingebourg Georg, Vitor Barreto Paravidino, Vitor Barreto Paravidino, Tatiana Rehder Gonçalves, Roberto Magalhães Saraiva, Mauro Felippe Felix Mediano, Mauro Felippe Felix Mediano   +22 more
doaj   +1 more source

Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM) [PDF]

, 2015
Background Trypanosoma cruzi, causative agent of Chagas disease, displays high intraspecific genetic diversity: six genetic lineages or discrete typing units (DTUs) are currently recognized, termed TcI through TcVI.
Bhattacharyya, T., Burleigh, B.A., Costales, J.A., Garcia-Perez, J., Kotton, C.N., Llewellyn, M.S., Messenger, L.A., Zurita-Leal, A.C.   +7 more
core   +2 more sources

Patterns of Cervical Metastases and Implications for Neck Management in Minor Salivary Gland Cancer Treatment

Head &Neck, EarlyView.
ABSTRACT Objectives Minor salivary gland cancer (MiSGC) is a rare and heterogeneous disease, with different degrees of tumor aggressiveness. The scarce data in the literature show that the presence of lymph node metastases (LNMs) negatively impacts the prognosis.
Eduardo Wanderley Estanislau da Costa, Pedro Nicolau‐Neto, Paula Moretz‐Sohn, Bernardo Cacciari Peryassu, Emilson de Queiroz Freitas, Luis Felipe Ribeiro Pinto, Fernando Luiz Dias   +6 more
wiley   +1 more source