Results 11 to 20 of about 309,855 (375)

An Overview on the Therapeutics of Neglected Infectious Diseases—Leishmaniasis and Chagas Diseases

Frontiers in Chemistry, 2021
Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas disease and leishmaniasis are reported to cause high mortality in humans and ...
Brindha J, Balamurali M. M, Kaushik Chanda   +2 more
doaj   +2 more sources

Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities

Frontiers in Pharmacology, 2023
Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions of Latin America.
Exequiel O. J. Porta, Karunakaran A Kalesh, P. Steel   +2 more
semanticscholar   +1 more source

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

Nature Microbiology, 2022
Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized.
A. Padilla, Wei Wang, T. Akama, D. S. Carter, E. Easom, Y. Freund, J. Halladay, Yang Liu, S. Hamer, CL Hodo, Gregory K Wilkerson, D. Orr, B. White, Arlene J. George, Huifeng Shen, Yiru Jin, Michael Zhuo Wang, Susanna Tse, R. Jacobs, R. Tarleton   +19 more
semanticscholar   +1 more source

Urban vectors of Chagas disease in the American continent: A systematic review of epidemiological surveys

PLoS Neglected Tropical Diseases, 2022
Background Chagas is a complex and multidimensional socio-environmental health phenomenon, in which different components converge and interact. Historically, this disease was associated with insect vectors found in the rural environment.
A. L. Carbajal-de-la-Fuente, Paz Sánchez-Casaccia, R. Piccinali, Y. Provecho, Liliana Salvá, Sergio Meli, Florencia Cano, R. Hernández, J. Nattero   +8 more
semanticscholar   +1 more source

A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Trypanosoma cruzi carbonic anhydrase (TcCA) has recently emerged as an interesting target for the design of new compounds to treat Chagas disease. In this study we report the results of a structure-based virtual screening campaign to identify novel and ...
Manuel A. Llanos, María L. Sbaraglini, María L. Villalba, María D. Ruiz, Carolina Carrillo, Catalina Alba Soto, Alan Talevi, Andrea Angeli, Seppo Parkkila, Claudiu T. Supuran, Luciana Gavernet   +10 more
doaj   +1 more source

The translational challenge in Chagas disease drug development

Memórias do Instituto Oswaldo Cruz, 2022
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations.
J. Kratz, K. R. Gonçalves, Lavínia Md Romera, C. Moraes, P. Bittencourt-Cunha, S. Schenkman, E. Chatelain, S. Sosa-Estani   +7 more
semanticscholar   +1 more source

The multidimensional comprehension of Chagas disease. Contributions, approaches, challenges and opportunities from and beyond the Information, Education and Communication field.

Memórias do Instituto Oswaldo Cruz, 2022
Chagas is a complex, multidimensional phenomenon in which political, economic, environmental, biomedical, epidemiological, psychological, and sociocultural factors intersect.
M. Sanmartino, Colin J. Forsyth, A. Avaria, Mar Velarde-Rodríguez, J. Gómez I Prat, P. Albajar-Viñas   +5 more
semanticscholar   +1 more source

Chagas' disease [PDF]

Clinical Microbiology Reviews, 1992
Chagas' disease, caused by Trypanosoma cruzi, is an important cause of morbidity in many countries in Latin America. The important modes of transmission are by the bite of the reduviid bug and blood transfusion. The organism exists in three morphological forms: trypomastigotes, amastigotes, and epimastigotes.
H B, Tanowitz, L V, Kirchhoff, D, Simon, S A, Morris, L M, Weiss, M, Wittner   +5 more
openaire   +2 more sources

Population movements, borders, and Chagas disease

Memórias do Instituto Oswaldo Cruz, 2022
Currently, Chagas disease is a complex global health problem with local and global implications. In the present article, we approach this complexity from the perspective of human mobility and its effects on people’s health in places of origin and in ...
A. Avaria, Laia Ventura-Garcia, M. Sanmartino, Carlos van der Laat   +3 more
semanticscholar   +1 more source

Recommendations for Screening and Diagnosis of Chagas Disease in the United States

Journal of Infectious Diseases, 2021
Background Chagas disease affects an estimated 326 000–347 000 people in the United States and is severely underdiagnosed. Lack of awareness and clarity regarding screening and diagnosis is a key barrier.
Colin J. Forsyth, J. Manne‐Goehler, C. Bern, Jeffrey D. Whitman, N. Hochberg, M. Edwards, R. Marcus, Norman L. Beatty, Yagahira E Castro, C. Coyle, Paula Stigler-Granados, D. Hamer, J. Maguire, R. Gilman, S. Meymandi   +14 more
semanticscholar   +1 more source