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Clinical Microbiology Reviews, 1992 Chagas' disease, caused by Trypanosoma cruzi, is an important cause of morbidity in many countries in Latin America. The important modes of transmission are by the bite of the reduviid bug and blood transfusion. The organism exists in three morphological forms: trypomastigotes, amastigotes, and epimastigotes.
H B, Tanowitz +5 more
openaire +2 more sources
Mitochondrial DNA Haplogroups and Variants Predispose to Chagas Disease Cardiomyopathy
Hearts, 2023 Cardiomyopathies are major causes of heart failure. Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central and South America.
Frédéric Gallardo +39 more
doaj +1 more source
Travel Medicine and Infectious Disease, 2022 BACKGROUND Chagas disease constitutes a public health problem, and Spain is the non-endemic country with the highest burden of disease outside the Americas. It represents a model for non-endemic countries regarding health policies to control the disease.
M. Navarro +4 more
semanticscholar +1 more source
Postgraduate Medical Journal, 2006 Abstract Chagas disease is the clinical condition triggered by infection with the protozoan Trypanosoma cruzi. The infection is transmitted by triatomine insects while blood feeding on a human host. Field studies predict that one third of an estimated 18 million T cruzi-infected humans in Latin America will die of Chagas disease.
A R L, Teixeira +4 more
openaire +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Trypanosoma cruzi carbonic anhydrase (TcCA) has recently emerged as an interesting target for the design of new compounds to treat Chagas disease. In this study we report the results of a structure-based virtual screening campaign to identify novel and ...
Manuel A. Llanos +10 more
doaj +1 more source
Nature Microbiology, 2022 Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized.
A. Padilla +19 more
semanticscholar +1 more source
Advances in the treatment of Chagas disease: Promising new drugs, plants and targets.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021 Chagas disease, caused by Trypanosoma cruzi, is treated with only two drugs; benznidazole and nifurtimox. These drugs have some disadvantages, including their efficacy only in the acute or early infection phases, adverse effects during their use, and the
P. García-Huertas, N. Cardona-Castro
semanticscholar +1 more source
PLoS Neglected Tropical Diseases, 2022 Background Chagas is a complex and multidimensional socio-environmental health phenomenon, in which different components converge and interact. Historically, this disease was associated with insect vectors found in the rural environment.
A. L. Carbajal-de-la-Fuente +8 more
semanticscholar +1 more source
The translational challenge in Chagas disease drug development
Memórias do Instituto Oswaldo Cruz, 2022 Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations.
J. Kratz +7 more
semanticscholar +1 more source
Recommendations for Screening and Diagnosis of Chagas Disease in the United States
Journal of Infectious Diseases, 2021 Background Chagas disease affects an estimated 326 000–347 000 people in the United States and is severely underdiagnosed. Lack of awareness and clarity regarding screening and diagnosis is a key barrier.
Colin J. Forsyth +14 more
semanticscholar +1 more source