Results 21 to 30 of about 312,210 (374)
Molecules, 2021 Several methoxybenzo[h]quinoline-3-carbonitrile analogs were designed and synthesized in a repositioning approach to developing compounds with anti-prostate cancer and anti-Chagas disease properties.
Hegira Ramírez +6 more
doaj +1 more source
Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities
Frontiers in Pharmacology, 2023 Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions of Latin America.
Exequiel O. J. Porta +2 more
semanticscholar +1 more source
Nature Microbiology, 2022 Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized.
A. Padilla +19 more
semanticscholar +1 more source
Mitochondrial DNA Haplogroups and Variants Predispose to Chagas Disease Cardiomyopathy
Hearts, 2023 Cardiomyopathies are major causes of heart failure. Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central and South America.
Frédéric Gallardo +39 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Trypanosoma cruzi carbonic anhydrase (TcCA) has recently emerged as an interesting target for the design of new compounds to treat Chagas disease. In this study we report the results of a structure-based virtual screening campaign to identify novel and ...
Manuel A. Llanos +10 more
doaj +1 more source
PLoS Neglected Tropical Diseases, 2022 Background Chagas is a complex and multidimensional socio-environmental health phenomenon, in which different components converge and interact. Historically, this disease was associated with insect vectors found in the rural environment.
A. L. Carbajal-de-la-Fuente +8 more
semanticscholar +1 more source
The translational challenge in Chagas disease drug development
Memórias do Instituto Oswaldo Cruz, 2022 Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations.
J. Kratz +7 more
semanticscholar +1 more source
Clinical Microbiology Reviews, 1992 Chagas' disease, caused by Trypanosoma cruzi, is an important cause of morbidity in many countries in Latin America. The important modes of transmission are by the bite of the reduviid bug and blood transfusion. The organism exists in three morphological forms: trypomastigotes, amastigotes, and epimastigotes.
H B, Tanowitz +5 more
openaire +2 more sources
Advances in the treatment of Chagas disease: Promising new drugs, plants and targets.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021 Chagas disease, caused by Trypanosoma cruzi, is treated with only two drugs; benznidazole and nifurtimox. These drugs have some disadvantages, including their efficacy only in the acute or early infection phases, adverse effects during their use, and the
P. García-Huertas, N. Cardona-Castro
semanticscholar +1 more source
Congenital Chagas Disease in the United States: Cost Savings Through Maternal Screening [PDF]
, 2018 Chagas disease, caused by Trypanosoma cruzi, is transmitted by insect vectors through transfusions, transplants, insect feces in food, and from mother to child during gestation.
Bialek, Stephanie R. +3 more
core +2 more sources