Results 91 to 100 of about 13,067 (212)

Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy: Clinical Practice Update

Journal of Education, Health and Sport
Background: Chronic Chagas cardiomyopathy is an arrhythmogenic, fibrosis-prone form of heart failure that develops years after Trypanosoma cruzi infection. Standard therapy has largely been extrapolated from non-Chagas trials.
Katarzyna Skibicka, Weronika Wesołowska, Tomasz Skibicki, Robert Bujak   +3 more
doaj   +1 more source

Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase [PDF]

, 2017
Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics.
Gallant, Joseph P.
core   +1 more source

Dysautonomic Arrhythmogenesis: A Working Hypothesis in Chronic Chagas Cardiomyopathy [PDF]

, 2020
Roberto Coury Pedrosa
openalex   +1 more source

Circulating Plasma MicroRNA-208a as Potential Biomarker of Chronic Indeterminate Phase of Chagas Disease

Frontiers in Microbiology, 2018
Chagas cardiomyopathy is the most severe clinical manifestation of chronic Chagas disease. The disease affects most of the Latin American countries, being considered one of the leading causes of morbidity and death in the continent.
Leandra Linhares-Lacerda, Leandra Linhares-Lacerda, Alessandra Granato, João Francisco Gomes-Neto, Luciana Conde, Leonardo Freire-de-Lima, Elisangela O. de Freitas, Celio G. Freire-de-Lima, Shana P. Coutinho Barroso, Rodrigo Jorge de Alcântara Guerra, Roberto C. Pedrosa, Wilson Savino, Wilson Savino, Alexandre Morrot, Alexandre Morrot   +14 more
doaj   +1 more source

Chagas' disease: an update on immune mechanisms and therapeutic strategies [PDF]

, 2010
The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order.
Abel, Abrahamsohn, Abrahamsohn, Albareda, Almeida, Alvarez, Alves, Araujo, Bafica, Bahia-Oliveira, Barr, Benvenuti, Bilate, Bixby, Bodley, Bonney, Boscardin, Bustamante, Bustamante, Cabeza Meckert, Caldas, Campos, Campos, Cardillo, Castanos-Velez, Cazzulo, Chamond, Cunha-Neto, Da Silva, Diez, Docampo, Duschak, Duthie, Dutra, Dutra, Engel, Esteva, Fonseca, Fonseca, Frank, Frank, Fuenmayor, Galvao Da Silva, Garg, Gattuso, Gomes, Gonzales-Perdomo, Hardison, Hardison, Higuchi, Hoft, Holscher, Hunter, Hyland, Kierszenbaum, Koga, Kotner, Krettli, Krettli, Kroll-Palhares, Kumar, Lages-Silva, Lages-Silva, Laucella, Lelchuk, Lelchuk, Lieke, Lima-Martins, Machado, Machado, Magdaleno, Manarin, Marin-Neto, Marinho, Martin, Maya, Michailowsky, Michailowsky, Moncayo, Muller, Murta, Nomizo, Okabe, Olivieri, Pascutti, Paveto, Piaggio, Piaggio, Punukollu, Reis, Revelli, Ribeirao, Rivarola, Rodrigues, Rodriques Coura, Romanha, Rottenberg, Rottenberg, Rottenberg, Rowland, Sales, Sanchez-Burgos, Santos Lima, Sathler-Avelar, Sathler-Avelar, Shoda, Soares, Souza, Stephens, Stolf, Stolić, Takeda, Talvani, Talvani, Tarleton, Tarleton, Tarleton, Tzelepis, Tzelepis, Tzelepis, Urbina, Urbina, Vaidian, Vasconcelos, Vitelli-Avelar, Walker   +125 more
core   +1 more source

Exploring global and specific pathogenic mechanisms in Chronic Chagas Cardiomyopathy through multi-omics integration [PDF]

, 2023
Pauline Brochet, Jorge Kalil, Vincent Procaccio, Edécio Cunha‐Neto, Lionel Spinelli, Christophe Chevillard   +5 more
openalex   +1 more source

Profile of soluble cell adhesion molecules as potential biomarkers in the cardiac stages of chronic Chagas disease

Frontiers in Immunology
Chagas cardiomyopathy is the most severe chronic manifestation and leading cause of mortality in the disease. Chronic inflammation, resulting from persistent infection by T.
Victor Vaitkevicius-Antão, Bruno Almeida Silva, Michelle da Silva Barros, Cíntia Nascimento da Costa-Oliveira, Byannca de Carvalho Torreão, Ana Carla da Silva, Silvia Marinho Martins, Cristina Carrazone, Wilson Oliveira, Carolina de Araújo Medeiros, Michelle Christiane da Silva Rabello, Virginia Maria Barros de Lorena   +11 more
doaj   +1 more source

Ventricular arrhythmias in Chagas disease

Revista da Sociedade Brasileira de Medicina Tropical, 2015
Sudden death is one of the most characteristic phenomena of Chagas disease, and approximately one-third of infected patients develop life-threatening heart disease, including malignant ventricular arrhythmias.
Marco Paulo Tomaz Barbosa, Andre Assis Lopes do Carmo, Manoel Otávio da Costa Rocha, Antonio Luiz Pinho Ribeiro   +3 more
doaj   +1 more source

Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study [PDF]

, 2016
Endothelin-1 (ET-1) is a potent vasoconstrictive peptide, and its activity is mediated by thetype A receptor (EDNRA). This action may play a significant role in the etiology of hypertension.There are different works that shows an association between ...
Bertolotto, Patricia Isolina, Dotto, Gladys, Garutti, Alicia, Herrera, Jimena María, Lassen, Oscar, Ojeda, Silvia, Sembaj, Adela, Tabares, Sandra   +7 more
core   +2 more sources

Effect of combined physical exercise program on improving the functional capacity and the cardiac autonomic modulation of Chagas cardiomyopathy [PDF]

, 2021
Diogo Van Bavel, Wallace Machado Magalhães de Souza, Yan de Britto Nery, Juliana Nascimento Amorin, Roberto Coury Pedrosa, Michel Silva Reis   +5 more
openalex   +1 more source