Results 81 to 90 of about 13,067 (212)

In Vitro Leishmanicidal Efficacy of Synthesized Arylidene Analogues of Glitazone

Drug Development Research, Volume 86, Issue 5, August 2025.
ABSTRACT Diabetes is a fast‐growing health issue in low‐ and middle‐income countries, with ~80% of diabetics living in the tropics and sub‐tropics. It is a deadly condition claiming the lives of millions of individuals annually, with no therapeutic treatment available to date. The management of diabetes is thus limited to symptomatic relief by glycemic
Janine Aucamp, Helena D. Janse van Rensburg, Simon S. Mnyakeni‐Moleele, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

Activation of Human CD11b+ B1 B-Cells by Trypanosoma cruzi-Derived Proteins Is Associated With Protective Immune Response in Human Chagas Disease

Frontiers in Immunology, 2019
B-cells mediate humoral adaptive immune response via the production of antibodies and cytokines, and by inducing T-cell activation. These functions can be attributed to distinct B-cell subpopulations. Infection with Trypanosoma cruzi, the causative agent
Livia Silva Araújo Passos, Livia Silva Araújo Passos, Luísa Mourão Dias Magalhães, Luísa Mourão Dias Magalhães, Rodrigo Pinto Soares, Rodrigo Pinto Soares, Alexandre F. Marques, Marina Luiza Rodrigues Alves, Rodolfo Cordeiro Giunchetti, Rodolfo Cordeiro Giunchetti, Maria do Carmo Pereira Nunes, Kenneth J. Gollob, Kenneth J. Gollob, Walderez Ornelas Dutra, Walderez Ornelas Dutra, Walderez Ornelas Dutra   +15 more
doaj   +1 more source

Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection

Vaccines, 2020
Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). We identified two candidate antigens (TcG2 and TcG4) that elicit antibodies and T cell responses in naturally infected diverse hosts.
Nandadeva Lokugamage, Subhadip Choudhuri, Carolina Davies, Imran Hussain Chowdhury, Nisha Jain Garg   +4 more
doaj   +1 more source

Genetic Variants Affect Distinct Metabolic Pathways in Pediatric Multisystem Inflammatory Syndrome and Severe COVID‐19

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT The coronavirus disease 2019 (COVID‐19) pandemic has triggered a global health crisis, with over 700 million confirmed cases and at least 7 million deaths reported by early 2024. Children are less vulnerable to severe SARS‐CoV‐2 infection than adults and typically experience milder respiratory symptoms.
Alysson Henrique Urbanski, Flávia Cristina de Paula Freitas, Tiago Minuzzi Freire da Fontoura Gomes, Michelle Orane Schemberger, Bárbara Carvalho Santos dos Reis, Flavia Amêndola Anísio de Carvalho, Roberta Soares Faccion, Lucas de Almeida Machado, Deborah Antunes dos Santos, Daniela Prado Cunha, Margarida dos Santos Salú, Daniella Campelo Batalha Cox Moore, Mayra Marinho Presibella, Juliana Fontes Noguchi, Henrique Lira Borges, Lais Kimie Tomiura, Luiza Silva de Castro, Letícia Graziela Costa Santos, Esdras Matheus Gomes da Silva, Vinícius Da Silva Coutinho Parreira, Luis Gustavo Morello, Fabricio Klerynton Marchini, Maria Regina Tizzot, Mauricio Marcondes Ribas, Gilberto Pascolat, Carmen Australia Paredes Marcondes Ribas, Fábio Fernandes da Rocha Vicente, Alexandre Rossi Paschoal, Rubens Cat, Benilton de Sá Carvalho, Jaqueline Carvalho de Oliveira, Marcus F. Oliveira, Luiz Lehmann Coutinho, Acácia Maria Lourenço Francisco Nasr, Irina Nastassja Riediger, Jeanine Marie Nardin, Liya Regina Mikami, Ana Carolina Ramos Guimarães, Patricia Savio de Araujo‐Souza, Arnaldo Prata‐Barbosa, Zilton Farias Meira de Vasconcelos, Helisson Faoro, Hellen Geremias dos Santos, Fabio Passetti   +43 more
wiley   +1 more source

Association between positive serology for COVID-19 and chagas cardiomyopathy progression: The SaMi-Trop project

Travel Medicine and Infectious Disease
Background: Chagas Disease (CD) can cause Chagas cardiomyopathy. The new coronavirus disease (COVID-19) also affects the cardiovascular system and may worsen Chagas cardiomyopathy.
Ariela Mota Ferreira, Léa Campos Oliveira-da Silva, Clareci Silva Cardoso, Cláudia Di Lorenzo Oliveira, Bruno Oliveira de Figueiredo Brito, Ana Luiza Bierrenbach, Ana Clara de Jesus Santos, Dardiane Santos Cruz, Sâmara Fernandes Leite, Andréia Brito Jesus, Renata Fiúza Damasceno, Maria Carmo Pereira Nunes, Israel Molina, Desirée Sant’ Anna Haikal, Ester Cerdeira Sabino, Antonio Luiz Pinho Ribeiro   +15 more
doaj   +1 more source

Abnormal ECG Findings in Athletes: Clinical Evaluation and Considerations. [PDF]

, 2019
PURPOSE OF REVIEW: Pre-participation cardiovascular evaluation with electrocardiography is normal practice for most sporting bodies. Awareness about sudden cardiac death in athletes and recognizing how screening can help identify vulnerable athletes have
A Biffi, A Biffi, A D’Silva, A D’Silva, A Magalski, A Malhotra, A Malhotra, A Malhotra, A Merghani, A Morshedi-Meibodi, A Pelliccia, A Pelliccia, A Zaidi, A Zaidi, A Zorzi, A Zorzi, A Zorzi, AD Desai, AL Aro, AL Rao, AO Usoro, BJ Maron, BJ Maron, C Antzelevitch, C Calore, C Daubert, C Miles, D Corrado, D Corrado, D Corrado, D Corrado, F D’Ascenzi, F Migliore, F Schnell, FI Marcus, G Finocchiaro, G Malfatto, G Mcclean, GJ Klein, GJ Klein, H Dhutia, H Morita, HUH Virk, J Basu, J Ehtisham, J Marek, J Novak, J Pei, J Steinfurt, JA Drezner, JA Drezner, KG Harmon, KM Park, L Calò, L Verdile, M Brosnan, M Papadakis, M Papadakis, M Sadron Blaye-Felice, MAE Haukilahti, Mark Abela, MG Wilson, MI Cohen, MJ Ackerman, MJ Brosnan, N Chandra, N Panhuyzen-goedkoop, N Sheikh, P Banankhah, PG Postema, PT Matusik, RE Bent, RE Eckart, S Gati, S Kapa, S Masrur, S Peters, S Sharma, S Viskin, Sanjay Sharma, SEE Page, T Senturk, X Li, YH Lee   +83 more
core   +1 more source

The year in cardiology: arrhythmias and pacing. [PDF]

, 2020
During this last year, there has been much progress with regard to anticoagulant and ablation therapy for atrial fibrillation (AF). Apart from recently issued European Society of Cardiology Guidelines for the management of patients with supraventricular ...
Calkins, H, Camm, AJ, Lip, GYH, Schilling, R, Steffel, J   +4 more
core   +4 more sources

Different infective forms trigger distinct immune response in experimental Chagas disease. [PDF]

, 2012
Although metacyclic and blood trypomastigotes are completely functional in relation to parasite-host interaction and/or target cell invasion, they differ in the molecules present on the surface.
Carneiro, Cláudia Martins, Fonseca, Kátia da Silva, Francisco, Amanda Fortes, Machado, Evandro Marques de Meneses, Martins-Filho, Olindo Assis, Nogueira, Nívia Carolina, Reis, Alexandre Barbosa, Tafuri, Washington Luiz, Teixeira-Carvalho, Andrea, Vieira, Paula Melo de Abreu   +9 more
core   +4 more sources

The risk of death according to left ventricular ejection fraction and right ventricular dilatation in 17 321 adults with heart failure from 40 high‐, middle‐ and low‐income countries – A Global Congestive Heart Failure (G‐CHF) study

European Journal of Heart Failure, Volume 27, Issue 7, Page 1191-1201, July 2025.
Abstract Aims The aim of this study was to describe the prognostic importance of left ventricular ejection fraction (LVEF) versus right ventricular (RV) dilatation and dysfunction in patients with heart failure (HF) from countries of different income levels. Methods and results We enrolled 17 321 participants with HF from 40 countries.
Darryl P. Leong, Philip G. Joseph, Hisham Dokainish, Stefan Störk, John V.V. McMurray, Lisa M. Mielniczuk, Sanjib Kumar Sharma, Andrés Orlandini, Kamilu M. Karaye, Antoni Bayes‐Genis, Tara McCready, Alex Grinvalds, Kumar Balasubramanian, Kelley R. Branch, Kristian Kragholm, Salim Yusuf, on behalf of the G‐CHF Investigators   +16 more
wiley   +1 more source

Current and future chemotherapy for Chagas disease [PDF]

, 2015
Luís Gaspar is thankful to FCT for funding (scholarship reference: SFRH/BD/81604/2011). The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreement No.602773 (Project KINDRED)
Cordeiro-da-Silva, Anabela, Coron, Ross P, Costantino, Luca, Costi, Maria Paola, Ferrari, Stefania, Freitas-Junior, Lucio H, Gaspar, Luís, McKerrow, James H, Moraes, Carolina B, Siqueira-Neto, Jair L, Smith, Terence Kenneth   +10 more
core   +1 more source