Results 61 to 70 of about 5,972,156 (311)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Chain-based lattice printing for efficient robotically-assembled structures
Communications EngineeringDue to the nature of their implementation, nearly all low-level fabrication processes produce solidly filled structures. However, lattice structures are significantly stronger for the same amount of material, resulting in structures that are much lighter
Zhe Xu, Aaron M. Dollar
doaj +1 more source
A direct slicing method for optimized lattice structures
Mechanics & IndustryPrevious research show that conventional CAD B-Rep methods are highly inefficient to design large lattice structures composed of several thousands of geometric primitives describing struts [2,3]. This paper aims at proposing a method for slicing directly
Foucault Gilles +2 more
doaj +1 more source
The four known biplanes with k=11
International Journal of Mathematics and Mathematical Sciences, 1979 The four known biplanes of order 9(k=11) are described in terms of their ovals, λ-chain structures, and automorphism groups. An exhaustive computer search for all biplanes of order 9 with certain chain structures has produced but two, one of which is new.
Chester J. Salwach, Joseph A. Mezzaroba
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Journal of Lipid Research, 1980 Proton nuclear magnetic resonance (1H-NMR) spectra at 90 MHz were measured for a number of side chain isomers of phytosterols (sterols with a C8H17 side chain, and delta 24-, 24-methylene, delta 22-, 24-ethylidene, 24-methly, 24-ethyl, 24-methyl-delta 22-
T Iida, T Tamura, T Matsumoto
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Crystal structures of the phosphorylation mimics of human cytosolic branched chain aminotransferase [PDF]
The phosphorylation sites of the human cytosolic Branched Chain Aminotransferase (hBCATc) mediated by mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated-kinase 2 (ERK2, also known as MAPK1) were mapped.
Newman, R. H. +5 more
core +1 more source
S-Chain: Structured Visual Chain-of-Thought For Medicine
CoRRFirst ...
Khai Le-Duc +23 more
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source