Results 171 to 180 of about 30,495 (265)

Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira, L. da Silva Lara, S. da Costa Lanera, T. Pérez de Souza, M. C. de Souza Pereira, G. L. Delogu, M. Silva dos Santos, M. J. Matos   +7 more
wiley   +1 more source

Functional characterization of BbCHI3 in regulating flavonoid biosynthesis and abiotic stress tolerance in Blumea balsamifera. [PDF]

BMC Plant Biol
Sha S, Li J, Mu K, Guo C, Yao S, Luo Q, Xie P, Shao C, Zhang Z, Sun W, Yuan Y, Ju Z, Pang Y.   +12 more
europepmc   +1 more source

Developmental and angiogenic safety profiles of novel pyridine-based chalcone. [PDF]

Front Pharmacol
Hassan AF, Kheraldine H, Idoudi S, Hussein OJ, Al-Thawadi H, Khalil A, Al Moustafa AE, Elhissi A.   +7 more
europepmc   +1 more source

Antibacterial and Antibiofilm Potential of Thymol-Benzimidazolium-Chalcone Hybrids Against Clinical MRSA Strains: Insights from Gene Expression Profiling and Molecular Docking. [PDF]

Antibiotics (Basel)
Yakut S, Ünver H, Yiğin A, Çimentepe M, Yıldız Zeyrek F, Öztürk Çimentepe Ö, Yildirim M.   +6 more
europepmc   +1 more source

Dual inhibition of neutrophil superoxide generation and elastase release <i>via</i> JNK, ERK and FAK pathways: blockade by methoxy-chalcone derivatives. [PDF]

RSC Adv
El-Gamil DS, Hammam MA, Emad M, Hafez DE, El-Shazly M, Chen YC, Wang YH, Kung PH, Korinek M, Hwang TL, Abdel-Halim M.   +10 more
europepmc   +1 more source

Synthesis and antibacterial study of aspirin-chalcone derivatives

, 2013
The chemistry of aspirin and chalcone derivatives has been extensively studied and developed as one of the pharmaceutically important molecules. In this study, new aspirin-chalcone derivatives have been successfully synthesized and characterized via FTIR,
Nurhayati Yusoff
core  

Chalcone-based Pyrazoline Derivatives as Modulators of Neuroinflammatory and Redox Pathways in Experimental Epilepsy. [PDF]

Mol Neurobiol
Delibaş EAÖ, Acungil ZK, Koç E, Özsoy Ş.   +3 more
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Methoxy-Substituted Chalcones and Gypsogenin-Based Hybrids as Anticancer and Antimicrobial Agents. [PDF]

ACS Omega
Ulusoy NG, Emirdağ S, Kahriman N, Demir F, Serdaroğlu V, Yaylı N, Türkmenoğlu B.   +6 more
europepmc   +1 more source

Discovery of Synthetic Imine-Chalcones Targeting Mayaro Virus Replication. [PDF]

Pathogens
Corrêa-Amorim LDS, Rocha NCD, Barboza GKP, Carlos MFLP, Echevarria A, Rabelo VW, Paixão ICNP.   +6 more
europepmc   +1 more source

Structural, electronic and bioactive profiling of a 2'-hydroxychalcone-Ag composite: a DFT-supported biomedical study on anticancer, antioxidant and antibacterial activities. [PDF]

RSC Adv
Butt AL, Saira F, Ahmed S, Tahir S, Iqbal A, Siddiqa A, Mazhar K, Sohaila Naz S.   +7 more
europepmc   +1 more source