Results 151 to 160 of about 33,682 (280)

Chalcone-based novel mono and bisthiocarbohydrazone: synthesis, crystal structure, antioxidant property and theoretical evaluation

This study describes the synthesis of novel chalconethiocarbohydrazones derived from 2′-hydroxychalcone and thiocarbohydrazide as potential drugs. The monothiocarbohydrazone (M1) and bisthiocarbohydrazone (M2) compounds were obtained by condensing ...
Avni Berisha (2177856), Yeliz Kaya (5689742), Ayşe Erçağ (5689745), Ahmed Zaki Lafta (18097435), Savaş Kaya (8938421), Yunus Zorlu (565924)   +5 more
core   +1 more source

Antioxidant Chemistry of Phenolics in Chinese Herbal Medicines: A Holism‐Based Review

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Phenolic antioxidants in CHMs mainly include chalcone, stilbene, flavonoid, xanthone, and Diels–Alder‐type adducts. They undergo direct and indirect pathways to exert antioxidant action. The indirect pathway is transition metal‐chelating, while the direct pathway comprises several redox‐based reactions (e.g., SET and HAT) and RAF reactions.
Xican Li
wiley   +1 more source

Two New Hydroxy Chalcone Derivatives from Thymus cilicicus

, 2007
The aerial part of Thymus cilicicus Linn. (Labiatae) has afforded two new hydroxy chalcone derivatives, characterized as 4, 2 , 4 , 6 , 7, 8-hexahydroxy-7 (8)-dihydro-chalcone (1), and 3, 4, 2 , 4 , 6 , 7, 8-heptahydroxy-7 (8)-dihydro-chalcone (2).
Bahar Ahmed, Tawfeq A Al-Howiriny
core  

Synthesis, Characterization, and Biological Assessment of 2‐Methoxynicotinonitrile Derivatives

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
We report the synthesis of new 2‐methoxy‐3‐cyanopyridine derivatives via the nucleophilic aromatic substitution pathway, along with their crystal structure determination and preliminary biological evaluation. The new synthetic conversion described here demonstrates a practical method of preparing structurally diverse 2‐methoxy‐3‐cyanopyridines and ...
Eman Sulaiman, Eman Al‐Masri, Maram B. Alhawarri, Mohammad M. Ibrahim, Mahmoud Al‐Refai, Basem F. Ali, Ali Shuaib   +6 more
wiley   +1 more source

Anti-Inflamatory Activities of Novel Chalcone Derivatives

Objective: Design and synthesis of two chalcone derivatives, evaluation of their anticancer and antiinflamatory activities. Methods: The ring-closure through an intramolecular Friedel-Crafts reaction followed by an alkaline-catalyzed Claisen-Schmidt ...
Ayaz, Furkan, Sevin, Sedat, Uyar, Recep, Yalçın, Ergin   +3 more
core   +1 more source

Classification, Structure–Activity Relationship, and Anti‐Osteoarthritis Mechanism of Natural Flavonoids

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Natural product flavonoids have a multi‐target therapeutic intervention effect on osteoarthritis. They promote autophagy and cartilage synthesis while alleviating oxidative stress, inhibiting inflammation, and inhibiting matrix degradation. By restoring OPG/RANKL balance and regulating bone metabolism, these compounds synergistically delay the ...
Haibin Wang, Shuqi Zheng, Chunlei Hua, Wanze Feng, Zengxia Liu, Yanhong Sun, Minhui Li   +6 more
wiley   +1 more source

Phytochemical Analysis Using LC–MS/MS and Anticancer Activity of Asphodelus tenuifolius Roots: Cell Cycle Arrest, Apoptosis, and In Silico Insights

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
LC–HRMS/MS profiling of the hydroethanolic root extract of A. tenuifolius identifies 58 metabolites, including luteolin, emodin, luteolin‐7‐O‐β‐D‐glucoside, subaphyllin, and N‐trans‐feruloyltyramine. Integrated biological and computational analyses reveal apoptosis induction, G0/G1 cell‐cycle arrest, and multi‐target interactions, highlighting the ...
Racha Lydia Bouchouka, Farida Larit, Zahia Kabouche, Marlène Debiossat, Laurent Riou, Catherine Ghezzi, Francisco León, Ahmed Kabouche   +7 more
wiley   +1 more source

Essential Oil Compositions and Biological Activities of Broussonetia papyrifera Aerial Parts: An Integrated In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Essential oils from B. papyrifera stem bark and leaves were characterized by a high abundance of oxygenated sesquiterpenes, particularly spathulenol and (Z)‐dihydro‐apofarnesol. Both essential oils exhibited antioxidant and anti‐inflammatory activities, along with moderate cytotoxic effects.
Ty Viet Pham, Nguyen Thi Thoa, Nguyen Thi Huong, Le The Hoai, Tran Quang Hai, Shaza W. Shantier, Nguyen Thi Kim Thanh, Phan Hong Minh, Huynh Thi Ngoc Ni, Vo Thi Dung, Ninh The Son   +10 more
wiley   +1 more source

High-throughput screening of a chalcone library identifies a naked-eye "traffic light" chemosensor for the discrimination of Cu²⁺ and Ni²⁺ in aqueous media. [PDF]

RSC Adv
Ciupa A.
europepmc   +1 more source

The Stetter Reaction between Glycolaldehyde and Electron‐Deficient Olefins

ChemCatChem, Volume 18, Issue 18, 28 September 2026.
Glycolaldehyde is a promising new bio‐derived compound and an attractive substrate for organic synthesis. In the present work, the N‐heterocyclic carbene‐catalyzed umpolung reaction is developed between glycolaldehyde and a range of electron‐deficient olefins such as methyl vinyl ketone, acrylates and several differently substituted chalcones ...
Philip Vinterberg, Robert Madsen
wiley   +1 more source