Results 131 to 140 of about 22,226 (252)

Chalcone Derivatives: Synthesis and Cytotoxicity Assays

Al-Nahrain Journal of Science
The research included the formation of chalcone derivatives, which are organic materials with biological importance, on which this research is based. The Chalcone derivatives were synthesised from the Claisen-Schmidt condensation reaction.
Asraa H. Ahmed, Ahmed Ahmed, Haikel Jelassi   +2 more
openaire   +1 more source

Identification and Functional Characterization of Isoflavone synthase Gene Family in Pea (Pisum sativum): The Entry Point to Pisatin Biosynthesis

Legume Science, Volume 8, Issue 2, June 2026.
ABSTRACT Isoflavone synthase (IFS), a cytochrome P450 monooxygenase of the CYP93C subfamily, catalyzes the conversion of flavanones into isoflavones, the first committed step in the biosynthesis of isoflavonoid phytoalexins. In pea (Pisum sativum L.), the phytoalexin pisatin plays a pivotal role in defense against pathogens.
Muhammad Sufyan Tahir, Kuflom Kuflu, Nishat Shayala Islam, Tim McDowell, Sangeeta Dhaubhadel   +4 more
wiley   +1 more source

Genetic control of wheat flour end‐use quality and rheology by genome‐wide association studies

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Improving end‐use quality in bread wheat (Triticum aestivum) requires dissecting the genetic basis of complex processing traits and deploying robust prediction pipelines in breeding. We performed genome‐wide association studies (GWASs) using 1767 high‐quality single‐nucleotide polymorphisms generated by genotyping‐by‐sequencing in a diverse ...
Juan Menor de Gaspar, Richard D. Cuthbert, Ruan Yuefeng, Ron Knox, BinXiao Fu, Kun Wang, Jatinder S. Sangah, Samia Berraies, Brad Meyer, Firdissa E. Bokore, Julio Isidro y Sánchez   +10 more
wiley   +1 more source

Transient [3,3] Cope rearrangement of 3,3-dicyano-1,5-dienes: computational analysis and 2-step synthesis of arylcycloheptanes. [PDF]

, 2018
A simple and modular route to arylcycloheptene scaffolds is reported. The two-step route from Knoevenagel adducts and allylic electrophiles is made possible through the design of a Cope rearrangement that utilizes a "traceless" activating group to ...
Fereyduni, Ehsan, Gonzalez, Gabriel, Grenning, Alexander J, Houk, KN, Sanders, Jacob N   +4 more
core   +1 more source

Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira, L. da Silva Lara, S. da Costa Lanera, T. Pérez de Souza, M. C. de Souza Pereira, G. L. Delogu, M. Silva dos Santos, M. J. Matos   +7 more
wiley   +1 more source

Synthesis, characterization, biological screening and in silico studies of novel pyrazole-chalcone derivatives as potent aromatase inhibitors for breast cancer therapy

Future Journal of Pharmaceutical Sciences
Background Chalcone derivatives, which are known for their non-steroidal anticancer properties, have been extensively studied. One potential application of chalcone is as aromatase inhibitors, a crucial strategy for treating estrogen receptor-positive ...
Ishvarchandra Parmar, Samir Patel, Umang Shah, Chirag Patel, Alkesh Patel, Arya Patel   +5 more
doaj   +1 more source

Design, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives

Drug Design, Development and Therapy, 2021
Semere Welday Kahssay,1 Gebremedhin Solomon Hailu,2 Kebede Taye Desta3 1Mizan-Tepi University, College of Health Sciences, School of Pharmacy, Department of Pharmaceutical Chemistry, Mizan-Aman, Ethiopia; 2Mekelle University, College of Health Sciences ...
Welday Kahssay S, Hailu GS, Taye Desta K
doaj  

Highly Lewis Acidic In Situ‐Generated Boronic Acid Ester: A Practical Catalyst for Hosomi–Sakurai Conjugate Addition, Carbonyl‐Ene Reaction, and Silane‐Mediated Amide Reduction

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
An exceptionally Lewis acidic boronic acid ester, generated in situ from pentafluorophenylboronic acid and tetrabromonaphthalenediol, catalyzes three important chemical transformations at 1–10 mol% loading: the Hosomi–Sakurai allylation of α,β‐unsaturated ketones, intermolecular carbonyl‐ene reactions, and the reductions of tertiary amides to amines ...
Ava Bousselat, Elisabeth Bats, Charbel Alkazzi, Karine Jarsale, Jacques Rouden, Jérôme Blanchet   +5 more
wiley   +1 more source

Photophysics of Biological and Biomimetic Sunscreen Molecules

ChemPhotoChem, Volume 10, Issue 5, May 2026.
Recent photochemical and photophysical research into natural and nature‐inspired UV filter molecules is reviewed, with a focus on the application of these systems in next‐generation sunscreens. The results of time‐resolved UV spectroscopy experiments and theoretical studies are discussed.
Michael Hymas, Vasilios G. Stavros
wiley   +1 more source

RETRACTED: Lokanath et al. Exploring Chalcone Derivatives as a Multifunctional Therapeutic Agent: Investigating Antioxidant Potential, Acetylcholinesterase Inhibition and Computational Insights. Drugs Drug Candidates 2025, 4, 16

Drugs and Drug Candidates
The journal retracts the article titled “Exploring Chalcone Derivatives as a Multifunctional Therapeutic Agent: Investigating Antioxidant Potential, Acetylcholinesterase Inhibition and Computational Insights” [...]
Sujatha M. Lokanath, Manjunatha S. Katagi, Girish S. Bolakatti, Johnson Samuel, Belakatte P. Nandeshwarappa   +4 more
doaj   +1 more source