Results 141 to 150 of about 22,032 (252)

Cardamonin Commands the Colonic Metabolite Columbianetin Acetate to Compete Against LPS in Binding HMGB1 in the Kidney, Preventing Lipopolysaccharide‐Induced Renal Tubular Pyroptosis

Food Frontiers, Volume 7, Issue 2, March 2026.
Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou, Xuechun Sun, Jian Zhou, Huali Meng, Pengfei Fan, Yufeng Chu, Hao Wu   +6 more
wiley   +1 more source

Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model [PDF]

, 2013
The role of potassium channels in nociceptive activity was proposed in the past decade. Various type of potassium channel has been found to exert different action in propogation of action potential in nervous system.
Akhtar, Muhammad Nadeem, Akira Omar, Farouk, Mohd Roslan, Sulaiman, Noor Azlina, Abu Bakar, Nordin, Lajis   +4 more
core  

Bioactive Phytochemical Compounds in Medicago sativa L. (Alfalfa): A Systematic Review of Biological Properties and Therapeutic Relevance in Nutraceutical and Functional Food Implications

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani, Hamid Rashidi Nodeh, Zahra Esfandiari, Giovanna Ferrentino   +3 more
wiley   +1 more source

Widely Targeted Metabolomics Reveals Differences in Secondary Metabolites in Oats With Different Grain Hardness

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
UHPLC–MS/MS and metabolomics revealed 409 differentially accumulated secondary metabolites between hard (HX320) and soft (HX317) oat cultivars. Key flavonoids, cirsilineol and swertiajaponin, showed synergistic effects potentially modulating reactive oxygen species.
Daxiao Zhang, Huiyan Liu, Ying Guo, Guanyu Chen, Meilin Chen, Xian Xian, Yuehua Zhang, Bing Han   +7 more
wiley   +1 more source

Improvement of Phenolic Compound and Anthocyanin Extraction Efficiency From Clitoria ternatea by Autogenous Pressurization Method in a Sealed‐Vessel and Determination of Anthocyanin Compounds by LC‐HRMS

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Closed‐vessel extraction under autogenous pressure (CVE‐AP) enhanced anthocyanin and phenolic compound recovery from Clitoria ternatea by improving solvent penetration and mass transfer while preserving flavonoid profiles confirmed by LC‐HRMS. ABSTRACT Clitoria ternatea L.
Kha Duyen Nguyen, Thi Thu Tra Tran, Thi Anh Dao Dong   +2 more
wiley   +1 more source

Electron Donor–Acceptor Complexes Without Preinstalled Sacrificial Leaving Groups: Applications in Synthesis

Helvetica Chimica Acta, Volume 109, Issue 3, March 2026.
Leaving‐group–free electron donor–acceptor (EDA) complexes have emerged as a practical platform for photocatalyst‐free radical generation under visible light. This review highlights recent advances in coupling and cyclization reactions driven by such EDA complexes, emphasizing their atom‐economical and sustainable feature.
Wenheng Liu, Line Næsborg
wiley   +1 more source

Synthesis, Antitumor Activity Evaluation and Mechanistic Study of Novel Bis‐Heterocyclic Chalcones Against Liver Cancer

Journal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.
Western blotting was performed to analyze the expression of Caspase 3 and Cleaved‐Caspase 3 in Huh1 cells following different treatments, which supports the finding that bis‐heterocyclic chalcones 3d and 3f can inhibit the activity of hepatocellular carcinoma cells by inducing apoptosis.
Zhifen Li, Jingbo Ma, Xiannian Lv, Lei Zhang, Hai Xie   +4 more
wiley   +1 more source

Synthesis of bis-Chalcones Based on Green Chemistry Strategies and Their Cytotoxicity Toward Human MeWo and A375 Melanoma Cell Lines

Molecules
Chalcone is an aromatic ketone that forms the central core of many important biological compounds. Chalcone derivatives show various biological activities, especially anti-inflammatory, antibacterial, antioxidant, and anticancer activities, and also ...
Dorota Olender, Anna Pawełczyk, Anna Leśków, Katarzyna Sowa-Kasprzak, Lucjusz Zaprutko, Dorota Diakowska   +5 more
doaj   +1 more source

Tomato‐Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity

Molecular Nutrition &Food Research, Volume 70, Issue 5, 12 March 2026.
Compared to pre‐intervention, consuming a tomato‐soy juice (54 mg lycopene, 189 mg soy isoflavones/d) reduced levels of inflammatory cytokines (IL‐5, IL‐12p70, and GM‐CSF, with TNF‐alpha trending downward), increased plasma lycopene and urinary soy isoflavone metabolites, and altered the urinary metabolome. ABSTRACT Chronic, low‐grade inflammation is a
Maria J. Sholola, Jenna Miller, Emma A. Bilbrey, Janet A. Novotny, David M. Francis, Thomas A. Mace, Jessica L. Cooperstone   +6 more
wiley   +1 more source

Biostimulatory Potential of Sargassum muticum Extracts in Enhancing Sesame Tolerance to Water Deficit During Germination and Seedling Growth

New Zealand Journal of Crop and Horticultural Science, Volume 54, Issue 1, March 2026.
Water deficit is a major abiotic stress that limits plant growth and productivity. This article evaluates the effectiveness of an aqueous seaweed extract (ASE) from Sargassum muticum as an ecofriendly biostimulant to alleviate water deficit stress during seed germination and early seedling growth of sesame (Sesamum indicum L.).
Soukaina Lahmaoui, Hamid Msaad, Omar Farssi, Nadia Lamsaadi, Ahmed El Moukhtari, Cherki Ghoulam, Walid Zorrig, Mohamed Farissi   +7 more
wiley   +1 more source