Results 151 to 160 of about 22,032 (252)

HvTT8 Regulates Proanthocyanidin Accumulation in the Barley Testa Layer by Transcriptionally Activating the Flavonoid Biosynthesis Pathway

Plant Direct, Volume 10, Issue 3, March 2026.
ABSTRACT Barley accumulates proanthocyanidins (PA), a type of flavonoid compound, in the testa layer. The accumulated PA have a detrimental effect on the quality of beer and pearled barley. Therefore, controlling PA accumulation in the testa layer is an important breeding objective in barley. PA accumulation is regulated by a ternary complex consisting
Yuki Nakano, Masaru Nakata, Hiromoto Yamakawa, Takuji Tonooka, Hidekazu Maejima, Takashi Nagamine   +5 more
wiley   +1 more source

Viral Pathogens and Pulmonary Fibrosis: EMT‐Driven Mechanisms and Insights From Traditional Chinese Medicine

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a serious progressive complication of the respiratory system, which is profoundly associated with persistent extracellular matrix (ECM) deposition, fibrosis, and disrupted tissue regeneration. Emerging evidence shows that epithelial–mesenchymal transition (EMT) acts as a key factor in the pathogenesis of ...
Ningzi Zang, Yingxu Wu, Pin Li, Yongming Liu, Shiwen Wang, Jiapeng Leng, Libin Zhan, Xiaodong Lyu, Lijian Pang, Jiaran Wang   +9 more
wiley   +1 more source

Pyrazoline Derivatives: Synthesis, In Silico, Enzyme Kinetics Studies and Biological Activity against Cholinesterase, Lipoxygenase, and α‐Amylase

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Nucleophilic cyclization of the α, β‐unsaturated carbonyl framework of the prepared (E)‐4‐(3‐bromo‐4‐hydroxy‐5‐methoxyphenyl)but‐3‐en‐2‐one with various hydrazine derivatives to afford their corresponding pyrazolines has been achieved. The enzyme assays conducted showed significant α‐amylase inhibitory activity for 4b with IC50 value of 2.7 µM.
Redolf S. Segodi, E. N. Agbo, Leoma B. Mofeli, K. W. Poopedi, O. O. Oderinlo, W. Nxumalo   +5 more
wiley   +1 more source

Rapid Structural Analysis of Natural Products Using MicroED

Small, Volume 22, Issue 15, 12 March 2026.
The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin, Orel Paz, Johan Unge, Tamir Gonen   +3 more
wiley   +1 more source

Molecular polymorphisms that underlie trait variation in crops: Lessons learned from soybean

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Genetic variation within a germplasm is important in crop improvement, providing a foundation for breeders to develop new varieties. Traits of agronomic and economic importance are often mapped to identify the genetic basis of observed phenotypes, oftentimes using quantitative trait locus (QTL) analysis.
Mary Jane C. Espina, Aaron J. Lorenz, Robert M. Stupar   +2 more
wiley   +1 more source

New Chalcone Derivatives Containing 2,4-Dichlorobenzenesulfonamide Moiety with Anticancer and Antioxidant Properties. [PDF]

Int J Mol Sci, 2023
Bułakowska A, Sławiński J, Hering A, Gucwa M, Ochocka JR, Hałasa R, Balewski Ł, Stefanowicz-Hajduk J.   +7 more
europepmc   +1 more source

Harnessing genomic resources for passion fruit improvement: Progress and prospects

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Passion fruit (Passiflora edulis) is a highly nutritious horticultural crop cultivated widely across tropical and subtropical regions. Despite decades of breeding efforts that have led to the release of a few high‐yielding cultivars, on‐farm productivity remains suboptimal, and several existing cultivars are showing signs of declining vigor ...
Khushboo Fulara, Vanika Garg, Xinhang Sun, Rebecca Ford, Natalie Dillon, Bruce Topp, Robert J. Henry, Mobashwer Alam, Rajeev K. Varshney   +8 more
wiley   +1 more source

A Scaffoldomics Platform for Modular In Vivo Enzyme Colocalisation and Its Application to Naringenin Biosynthesis

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
A hierarchical assembly system was established in which the coding sequences for four docking enzymes and a scaffold are co‐assembled onto a single plasmid, thereby establishing a ‘scaffoldomics’ platform for the optimisation of multi‐enzyme biosynthetic pathways.
Marte Elias, Brecht De Paepe, Julie Vanderstraeten, Babette Lamote, Marjan De Mey, Yves Briers   +5 more
wiley   +1 more source

Targeting Ovarian Cancer with Chalcone Derivatives: Cytotoxicity and Apoptosis Induction in HGSOC Cells. [PDF]

Molecules, 2023
Merve Aydin E, Canıtez İS, Colombo E, Princiotto S, Passarella D, Dallavalle S, Christodoulou MS, Durmaz Şahin I.   +7 more
europepmc   +1 more source

Design, Synthesis, and Evaluation of Bis‐Chalcones and Bis‐Flavones as Selective COX‐2 Inhibitors

Chemical Biology &Drug Design, Volume 107, Issue 3, March 2026.
Novel bis‐chalcones were successfully synthesized and demonstrated COX‐2 selective inhibition and the ability to inhibit PGE2 production in whole human blood. Notably, a monomeric chalcone with a similar substitution pattern exhibited even greater activity, providing valuable insights to guide the future design and optimization of flavonoid‐based COX‐2
Rui Pereira, Marisa Freitas, Alberto N. Araújo, Vera L. M. Silva, Eduarda Fernandes   +4 more
wiley   +1 more source