Results 241 to 250 of about 22,032 (252)

Cytotoxicity of chalcone derivatives towards glioblastoma.

Anticancer research, 2011
Among seventeen compounds derived from chalcones investigated as potential anticancer drugs towards LN229 glioblastoma cell line, only two were effective.Anticancer activity was investigated by evaluating the cell growth, cell cycle, mitotic index and the cell death.Two compounds, namely C2 and C12, inhibited cell proliferation associated with a ...
P, Champelovier, M, Mininno, E, Duchamp, E, Nicolle, V, Curri, A, Boumendjel, J, Boutonnat   +6 more
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Chalcone Derivatives with Potential Antimitotic Activity

Background: Cancer remains one of the leading causes of mortality worldwide, with incidence rates rising in recent years [1]. Among various therapeutic strategies, microtubule-targeting agents have demonstrated significant efficacy in cancer treatment.
Silva, Patrícia M. A., Alves, Eduarda, Cruz, Lara, Santos, Rita, Pereira, Daniela, Assunção, Henrique, Cidade, Honorina, Bousbaa, Hassan   +7 more
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Methoxy Chalcone Derivatives: Promising Antimicrobial Agents Against Phytopathogens

Chemistry & Biodiversity
AbstractChalcone (E)‐1,3‐diphenyl‐prop‐2‐en‐1‐one and a series of 14 methoxylated derivatives have been synthesized via Claisen–Schmidt aldol condensation and characterized by FTIR, CG/MS/DIC, 1D (1H and 13C), 2D (COSY, HSQC, and HMBC) NMR, and EMAR techniques. All molecules were tested at 1 mM concentration for antifungal (Sclerotium sp., Macrophomina
Tamiris A. C. Santos, Cassia Sousa Ferreira, Péricles Barreto Alves, Ricardo Scher, Liciane Assis Pinheiro, Emmanoel Vilaça Costa, Paulo Roberto Gagliardi, Roberta P. M. Fernandes   +7 more
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Allosteric inhibition of PTP1B by bromocatechol-chalcone derivatives

European Journal of Medicinal Chemistry
Development of allosteric inhibitors may be a viable strategy to discover hypoglycemic drugs targeting PTP1B. Allosteric inhibitors occupying the BB site that is a hydrophobic pocket restrict the WPD loop in an open conformation, preventing the physiological dephosphorylation reaction.
Chenxia Gao, Wenpeng Hu, Feng Xu, Yuxi Lin, Jiashu Chen, Dayong Shi, Pan Xing, Jiqiang Zhu, Xiangqian Li   +8 more
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Chalcone Derivatives As Potential Biological Activities

Chalcones are the biogenetic precursors of flavonoids and Isoflavonoids, which are abundant in plants. Chalcones are active lead molecules in medicinal chemistry for the discovery of new drugs. Here, we review properties, biosynthesis and structural diversity of natural chalcones.
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Thioxanthone-chalcone derivatives for LED photopolymerization

Progress in Organic Coatings
Qingqing Wu, Hujun Shen, Yan Yang, Fushao Li, Mingsen Deng   +4 more
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Upconversion photoluminescence of chalcone derivatives

AIP Conference Proceedings
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Pharmacology of some new chalcone derivatives.

Acta physiologica Academiae Scientiarum Hungaricae, 1969
M, Gábor, J, Sallai, T, Széll
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Chalcones and their Derivatives

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Chalcone derivatives

Zwaagstra, M.E., Zhang, M.Q., Timmerman, H., Onogi, K., Tamura, M., Toma, T., Wada, Y.   +6 more
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