Results 221 to 230 of about 22,226 (252)

Chalcone derivatives and their antibacterial activities: Current development

Bioorganic Chemistry, 2019
The increase in antibiotic resistance due to various factors has encouraged the look for novel compounds which are active against multidrug-resistant pathogens. In this framework, chalcone-based compounds showed a diversity of pharmacological properties, and its derivatives possess a high degree of structural diversity, and it is helpful for the ...
Man, Xu, Piye, Wu, Fan, Shen, Jiayou, Ji, K P, Rakesh   +4 more
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Development of chalcone-based derivatives for sensing applications

Analytical Methods, 2020
In this review, design strategies, sensing mechanism, and sensing performance of ion chemosensors based on various chalcone derivatives are described using extensive examples. We believe that this review provides valuable information for researchers of related areas.
Ankush Gupta, Shelly Garg, Harminder Singh   +2 more
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β-Ionone derived chalcones as potent antiproliferative agents

European Journal of Medicinal Chemistry, 2013
A series of β-ionone derived chalcones were evaluated for cytotoxic activity against various human cancer cell lines using SRB dye assay. All the compounds displayed moderate to high cytotoxic effect against almost all the cancer cell lines. The results also revealed the effect of substituents of the aromatic ring on their inhibitory potential.
Vishal, Sharma, Ashun, Chaudhary, Saroj, Arora, Ajit K, Saxena, Mohan Paul S, Ishar   +4 more
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Anti-inflammatory cyclohexenyl chalcone derivatives in Boesenbergia pandurata

Phytochemistry, 2002
The cyclohexenyl chalcone derivative [(-)-hydroxypanduratin A], together with the previously known panduratin A, sakuranetin, pinostrobin, pinocembrin, and dihydro-5,6-dehydrokawain were isolated from the chloroform extract of the red rhizome variety of Boesenbergia pandurata (Robx.) Schltr.
Patoomratana, Tuchinda, Vichai, Reutrakul, Per, Claeson, Ubonwan, Pongprayoon, Tuanta, Sematong, Thawatchai, Santisuk, Walter C, Taylor   +6 more
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Novel Resveratrol-chalcone Derivatives: Synthesis and Biological Evaluation

Mini-Reviews in Medicinal Chemistry, 2019
Introduction: Resveratrol and chalcones are lead compounds with good biological activities. </P><P> Method: In this study, a series of novel derivatives (6-38) between resveratrol and chalcone possessing piperazine moiety have been synthesized, and in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW-264.7 ...
Yulu, Ma, Xi, Zheng, Ping, Zhu, Bei, Liu, Hui, Gao, Zewei, Mao, Lijun, Zhang, Chunping, Wan   +7 more
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Cytotoxicity of chalcone derivatives towards glioblastoma.

Anticancer research, 2011
Among seventeen compounds derived from chalcones investigated as potential anticancer drugs towards LN229 glioblastoma cell line, only two were effective.Anticancer activity was investigated by evaluating the cell growth, cell cycle, mitotic index and the cell death.Two compounds, namely C2 and C12, inhibited cell proliferation associated with a ...
P, Champelovier, M, Mininno, E, Duchamp, E, Nicolle, V, Curri, A, Boumendjel, J, Boutonnat   +6 more
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Chalcone Derivatives with Potential Antimitotic Activity

Background: Cancer remains one of the leading causes of mortality worldwide, with incidence rates rising in recent years [1]. Among various therapeutic strategies, microtubule-targeting agents have demonstrated significant efficacy in cancer treatment.
Silva, Patrícia M. A., Alves, Eduarda, Cruz, Lara, Santos, Rita, Pereira, Daniela, Assunção, Henrique, Cidade, Honorina, Bousbaa, Hassan   +7 more
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Methoxy Chalcone Derivatives: Promising Antimicrobial Agents Against Phytopathogens

Chemistry & Biodiversity
AbstractChalcone (E)‐1,3‐diphenyl‐prop‐2‐en‐1‐one and a series of 14 methoxylated derivatives have been synthesized via Claisen–Schmidt aldol condensation and characterized by FTIR, CG/MS/DIC, 1D (1H and 13C), 2D (COSY, HSQC, and HMBC) NMR, and EMAR techniques. All molecules were tested at 1 mM concentration for antifungal (Sclerotium sp., Macrophomina
Tamiris A. C. Santos, Cassia Sousa Ferreira, Péricles Barreto Alves, Ricardo Scher, Liciane Assis Pinheiro, Emmanoel Vilaça Costa, Paulo Roberto Gagliardi, Roberta P. M. Fernandes   +7 more
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Allosteric inhibition of PTP1B by bromocatechol-chalcone derivatives

European Journal of Medicinal Chemistry
Development of allosteric inhibitors may be a viable strategy to discover hypoglycemic drugs targeting PTP1B. Allosteric inhibitors occupying the BB site that is a hydrophobic pocket restrict the WPD loop in an open conformation, preventing the physiological dephosphorylation reaction.
Chenxia Gao, Wenpeng Hu, Feng Xu, Yuxi Lin, Jiashu Chen, Dayong Shi, Pan Xing, Jiqiang Zhu, Xiangqian Li   +8 more
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Design, Synthesis, and Antifungal Activity of Novel Chalcone Derivatives Containing a Piperazine Fragment

Journal of Agricultural and Food Chemistry, 2022
薛伟, Shuai Chen, Wei Xue
exaly