Results 61 to 70 of about 22,032 (252)

Chalcone suppresses tumor growth through NOX4-IRE1α sulfonation-RIDD-miR-23b axis

Redox Biology, 2021
Chalcone is a polyphenolic compound found abundantly in natural plant components. They have been acclaimed as potential antitumor compounds in multiple tumor cells. However, not much attention has been paid to elucidate its antitumor mechanism of action.
Hyun-Kyoung Kim, Hwa-Young Lee, Thoufiqul Alam Riaz, Kashi Raj Bhattarai, Manoj Chaudhary, Jin Hee Ahn, Jieun Jeong, Hyung-Ryung Kim, Han-Jung Chae   +8 more
doaj   +1 more source

Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model [PDF]

, 2014
[[abstract]]The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological ...
Ajaiyeoba, Chao-Yuan Chang, Ching-Yuh Chern, De Vasconcelos, Hui-Min Chen, Tsorng-Harn Fong, Westerfield, Ya-Ting Lee, Yau-Hung Chen, Yun-Hsin Wang   +9 more
core   +2 more sources

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, EarlyView.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity [PDF]

, 2019
A series of benzo[b]thiophen-3-ols were synthesised and investigated as potential human monoamine oxidase (hMAO) inhibitors in vitro as well as ex vivo in rat cortex synaptosomes by means of evaluation of 3,4-dihydroxyphenylacetic acid/dopamine (DOPAC/DA)
Alcaro, Stefano, Bagetta, Donatella, Carradori, Simone, Chimenti, Paola, Ferrante, Claudio, Guglielmi, Paolo, Leone, Sheila, Ortuso, Francesco, Petzer, Anél, Petzer, Jacobus P, Recinella, Lucia, Rotondi, Giulia, Secci, Daniela, Zengin, Gokhan   +13 more
core   +1 more source

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Silencing CHALCONE SYNTHASE in maize impedes the incorporation of tricin into lignin and increases lignin content [PDF]

, 2016
Lignin is a phenolic heteropolymer that is deposited in secondary-thickened cell walls, where it provides mechanical strength. A recent structural characterization of cell walls from monocot species showed that the flavone tricin is part of the native ...
Boerjan, Wout, Cesarino, Igor, de Lyra Soriano Saleme, Marina, Eloy, Nubia Barbosa, Goeminne, Geert, Lan, Wu, Morreel, Kris, Nicomedes, José Junior, Pallidis, Andreas, Ralph, John, Smith, Rebecca, Vanholme, Ruben, Voorend, Wannes   +12 more
core   +1 more source

Synthesis, Structure and In Vitro Anti-Trypanosomal Activity of Non-Toxic Arylpyrrole-Based Chalcone Derivatives

Molecules, 2020
With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields.
Ayanda I. Zulu, Ogunyemi O. Oderinlo, Cuan Kruger, Michelle Isaacs, Heinrich C. Hoppe, Vincent J. Smith, Clinton G. L. Veale, Setshaba D. Khanye   +7 more
doaj   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Design, synthesis, and in-silico studies of novel pyrazole-fused chalcone amine derivatives as anti-inflammatory agents

Discover Chemistry
Objectives This research involves the development, synthesis, in-silico ADMET and molecular docking studies, and in-vitro anti-inflammatory analysis of chalcone-linked pyrazole amine compounds.
Siddhartha Sankar Das, Nilotpal Choudhury, Chandan Das, Babita Deka, Bhargab Jyoti Sahariah, Pooja Patowary   +5 more
doaj   +1 more source

University teaching of mass spectrometry as a key practical technique within the context of a fully integrated, spiral curriculum

Rapid Communications in Mass Spectrometry, EarlyView.
Rationale Mass spectrometry (MS) is introduced to high school students in the UK in many pre‐university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their studies.
Andrew F. Worrall, Craig D. Campbell, Megan O. Midson, Malcolm I. Stewart   +3 more
wiley   +1 more source