Results 71 to 80 of about 22,226 (252)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Synthesis and Preliminary Evaluation of Several Chalcone Derivatives as Sunscreen Compounds

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2019
Four chalcone derivatives were synthesized and pre-evaluated as broad-spectrum UV protector. Chalcones 1-4 showed a wide range of UV absorbance values and moderate molar absorptivity values. Chalcones 3 and 4 showed better photostability than chalcones 1
Jumina Jumina, Rizky Woro Styaningrum, Dwi Siswanta, Sugeng Triono, Yoga Priastomo, Harizal Harizal, Eti Nurwening Sholikhah, Abdul Karim Zulkarnain   +7 more
doaj   +1 more source

Chalcone analogue as potent anti-malarial compounds against Plasmodium falciparum: Synthesis, biological evaluation, and docking simulation study

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To investigate in vitro antimalarial activity of chalcone derivative compounds against Plasmodium falciparum 3D7 (Pf3D7) strain and in silico antimalarial activity.
Jufrizal Syahri, Emmy Yuanita, Beta Achromi Nurohmah, Ria Armunanto, Bambang Purwono   +4 more
doaj   +1 more source

Synthesis and mesomorphic properties of new heterocyclic liquidcrystals with Central Ester–Chalcone linkages [PDF]

, 2017
A series of new calamitic liquid crystals, 4-[3-(pyridin-4-yl)prop-2-enoyl]phenyl 4-alkyloxybenzoates, comprising a pyridyl core,ester–chalcone central linkage and terminal alkyloxy chain were synthesized and characterized.
Ha, Sie Tiong, Lim, Chery Yong Wei, Sastry, S. Sreehari, Yeap, Guan Yeow   +3 more
core   +1 more source

Efficacy of Organophosphorus Derivatives ContainingChalcones/Chalcone Semicarbazones Against Fungal Pathogens ofSugarcane [PDF]

Metal-Based Drugs, 2002
Ten newly synthesized organophosphorus derivatives containing substituted chalcones and substituted chalcone semicarbazones were tested for their antifungal efficacy against Colletotrichum falcatum, Fusarium oxysporum, Curvularia pallescens (all sugarcane pathogens).
Sengupta, S. K., Pandey, O. P., Rao, G. P., Singh, Priyanka   +3 more
openaire   +2 more sources

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties [PDF]

, 2016
Nicotine acethylcholine receptors (nAChRs) play critical roles in cognitive processes, neuroprotection and inflammation. Results: According to their substituents, 1,3-diphenylpropan-1-one derivatives act as α7 nAChRs negative allosteric modulators (NAM ...
Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Beatriz Balsera, Francisco Sala, José Mulet, Manuel Criado, Marta Miguel, María Jesús Pérez de Vega, Roberto de la Torre-Martínez, Rosario González-Muñiz, Salvador Sala, Silvia Moreno-Fernández   +11 more
core   +1 more source

University teaching of mass spectrometry as a key practical technique within the context of a fully integrated, spiral curriculum

Rapid Communications in Mass Spectrometry, EarlyView.
Rationale Mass spectrometry (MS) is introduced to high school students in the UK in many pre‐university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their studies.
Andrew F. Worrall, Craig D. Campbell, Megan O. Midson, Malcolm I. Stewart   +3 more
wiley   +1 more source

Ultrastructural alterations in Plasmodium falciparum induced by chalcone derivatives

BMC Research Notes, 2020
Objective Chalcones (1, 3-diaryl-2-propen-1-ones) and their derivatives are widely explored from the past decade for its antimalarial activity. To elucidate their mechanism of action on the malaria parasite, the ultrastructural changes with the action of
Shweta Sinha, B. D. Radotra, Bikash Medhi, Daniela I. Batovska, Nadezhda Markova, Rakesh Sehgal   +5 more
doaj   +1 more source

Chalcone-based Selective Inhibitors of a C4 Plant Key Enzyme as Novel Potential Herbicides [PDF]

, 2016
Weeds are a challenge for global food production due to their rapidly evolving resistance against herbicides. We have identified chalcones as selective inhibitors of phosphoenolpyruvate carboxylase (PEPC), a key enzyme for carbon fixation and biomass ...
Bott, M., Erlenkamp, G., Fiorani, F., Gohlke, H., Groth, G., Jäck, O., Küberl, A., Nguyen, G. T. T.   +7 more
core   +2 more sources