Results 81 to 90 of about 22,032 (252)

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Studies on Synthesis of Some Novel Heterocyclic Chalcone, Pyrazoline, Pyrimidine - 2 - One, Pyrimidine - 2 - Thione, para-Acetanilide Sulphonyl and Benzoyl Derivatives and their Antimicrobial Activity

E-Journal of Chemistry, 2005
1, 2 - Dichloro benzene on chlorosulphonation by chlorosulphonic acid gives 1, 2 - [dichloro] - benzene sulphonyl chloride which on condensation with p –amino acetophenone gives 1-[acetyl] -
Rakesh N. Mistry, K. R. Desai
doaj   +1 more source

Discovery of a novel chalcone derivative inhibiting CFTR chloride channel via AMPK activation and its anti-diarrheal application

Journal of Pharmacological Sciences, 2019
Secretory diarrhea is one of the most common causes of death world-wide especially in children under 5 years old. Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by ...
Chamnan Yibcharoenporn, Phakawat Chusuth, Chanon Jakakul, Thanyada Rungrotmongkol, Warinthorn Chavasiri, Chatchai Muanprasat   +5 more
doaj   +1 more source

Stereoselective photodimerisation of chalcones in the molten state [PDF]

, 1998
Photodimerisations of chalcone and its derivatives in the molten state proceed efficiently and stereoselectively to give rac-anti-head-to-head dimers in all cases ...
Kato Masako, Tanaka Koichi, Toda Fumio, 加藤 昌子, 戸田 芙三夫, 田中 耕一   +5 more
core   +2 more sources

The multidimensional regulation roles and mechanisms of calcium in fruit quality

Journal of Integrative Plant Biology, EarlyView.
This review explores how calcium signaling molecule integrates plant hormones, environmental cues, and developmental signals to influence external fruit traits, internal nutritional properties, and physiological disorders. ABSTRACT Calcium (Ca2+), a dual‐functional mineral that serves both as an essential structural factor and a signaling molecule ...
Fei Jiang, Siyang Gao, Mengdi Li, Zeqi Zhao, Chengwei Yang, Ji‐Hong Liu, Chunlong Li   +6 more
wiley   +1 more source

Synthesis and biological evaluation of N-substituted indole chalcone derivatives as potent antitubercular agents

Future Journal of Pharmaceutical Sciences
The in vitro antitubercular activity of a new family of N-substituted indole chalcone analogues against Mycobacterium Tuberculosis H37Rv has been synthesized and evaluated.
Shivam Joshi, Neha Kawathekar
doaj   +1 more source

New Chalcone Derivatives: Synthesis, Characterization, Antioxidant, Antimicrobial, and Docking Study Against GLcN-6-P Synthase

Al-Mustansiriyah Journal of Science
Background: Chalcone derivatives are well-known for their versatile pharmacological properties, particularly their antimicrobial and antioxidant activities.
Jameel A. M. Al-Duraye , Ahmed Mutanabbi Abdula, Younis Baqi   +2 more
doaj   +1 more source

Synthesis, leishmanicidal, trypanocidal and cytotoxic activities of quinoline-chalcone and quinoline-chromone hybrids [PDF]

, 2017
We report herein the synthesis and biological activities (cytotoxicity, leishmanicidal and trypanocidal) of six quinoline-chalcone and five quinoline-chromone hybrids.
Elisa García, Iván D. Vélez, Juan C. Coa, July A. Muñoz, Lina M. Yepes, Miguel Carda, Raúl Agut, Sara M. Robledo, Wilson I. Cardona   +8 more
core   +2 more sources

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum

Plant Biotechnology Journal, EarlyView.
ABSTRACT Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Qianle Zhang, Qingwen Wu, Wenjing Shi, Yinai Deng, Ruoting Zhan, Dongming Ma   +5 more
wiley   +1 more source

Phytoestrogens [PDF]

, 2004
Collectively, plants contain several different families of natural products among which are compounds with weak estrogenic or antiestrogenic activity toward mammals.
Adlercreutz H, Alekel DL, Bhathena SJ, Bielenberg J, Biendl M, Boller B, Dai Q, Day JK, de Kleijn MJJ, den Tonkelaar I, denTonkelaar I, Dewick PM, Ebisawa H, Fritz WA, Guo TL, Hodgson JM, Horn-Ross PL, ILDIS, Kim CS, Lamartiniere CA, Maggiolini M, Maskarinec G, McCann SE, Mentor MR, MerzDemlow BE, Newbold RR, Pan W, Peluso MR, Richard A. Dixon, Seested S, Setchell KDR, Setchell KDR, Setchell KDR, Slavin JL, Stevens JF, Whitten PL, Yanagihara K, Zhang Y   +37 more
core   +1 more source