Results 41 to 50 of about 10,695 (200)

Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges

ChemMedChem, Volume 20, Issue 6, March 15, 2025.
The post‐COVID syndromes are strictly dependent from inflammaging and immunosenescence, for which the available treatments, particularly immunotherapy, have limited impact and safety issues. Alternative targets are under validation to disclose, besides anti‐inflammatory drugs, new small molecular entities able to counteract the imbalance of ...
Fabio Francavilla, Francesca Intranuovo, Gabriella La Spada, Enza Lacivita, Marco Catto, Elisabetta Anna Graps, Cosimo Damiano Altomare   +6 more
wiley   +1 more source

Subunit rotation in a single FoF1-ATP synthase in a living bacterium monitored by FRET [PDF]

, 2011
FoF1-ATP synthase is the ubiquitous membrane-bound enzyme in mitochondria, chloroplasts and bacteria which provides the 'chemical energy currency' adenosine triphosphate (ATP) for cellular processes. In Escherichia coli ATP synthesis is driven by a proton motive force (PMF) comprising a proton concentration difference {\Delta}pH plus an electric ...
arxiv   +1 more source

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, EarlyView.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

Fast ATP-dependent Subunit Rotation in Reconstituted FoF1-ATP Synthase Trapped in Solution [PDF]

arXiv, 2021
FoF1-ATP synthases are ubiquitous membrane-bound, rotary motor enzymes that can catalyze ATP synthesis and hydrolysis. Their enzyme kinetics are controlled by internal subunit rotation, by substrate and product concentrations, by mechanical inhibitory mechanisms, but also by the electrochemical potential of protons across the membrane.
arxiv  

Sustainable and Scalable Enzymatic Production, Structural Elucidation, And Biological Evaluation of Novel Phlorizin Analogues

ChemSusChem, Volume 18, Issue 8, April 14, 2025.
New α‐glycosides of chalcones and dihydrochalcones, analogues of naturally occurring phlorizin, have been synthesized using a CGTase‐catalyzed glycosylation that was successfully scaled‐up in a 10‐liter reactor. The α‐glycosides were (i) purified using an original centrifugal partition chromatography technique, (ii) characterized through NMR and LC–MS ...
Laurène Minsat, Yueying Li, Cédric Peyrot, Agathe Martinez, Nicolas Borie, Aurélien Peru, Blandine Godon, Clément Nève, Fanny Brunissen, Fanny Brunois, Abdouramane Dosso, Florent Allais, Jean‐Hugues Renault   +12 more
wiley   +1 more source

In silico identification of Capsicum type III polyketide synthase genes and expression patterns in Capsicum annuum

Open Life Sciences, 2020
Studies have shown that abundant and various flavonoids accumulate in chili pepper (Capsicum), but there are few reports on the genes that govern chili pepper flavonoid biosynthesis. Here, we report the comprehensive identification of genes encoding type
Kan Delong, Zhao Di, Duan Pengfei
doaj   +1 more source

Phylogenetic Implications and Functional Disparity in the Chalcone synthase Gene Family of Common Seagrass Zostera marina

Frontiers in Marine Science, 2021
Chalcone synthase (CHS) family are plant type III polyketide synthases that participate in the flavonoid synthesis pathway to induce plant resistance to various biotic and abiotic stresses.
Mingyu Ma, Mingyu Zhong, Quansheng Zhang, Wei Zhao, Mengxin Wang, Chengying Luo   +5 more
doaj   +1 more source

Detecting substeps in the rotary motors of FoF1-ATP synthase by Hidden Markov Models [PDF]

, 2007
FoF1-ATP synthase is the enzyme that provides the 'chemical energy currency' adenosine triphosphate, ATP, for living cells. The formation of ATP is accomplished by a stepwise internal rotation of subunits within the enzyme. We monitor subunit rotation by a single-molecule fluorescence resonance energy transfer (FRET) approach using two fluorophores ...
arxiv   +1 more source

How Does Nature Create the Painting “Gradient Coloration of ‘Manicure Finger’ Grape”? Integrated Omics Unveil the Pigments Basis and Metabolism Networks of Its Formation

Food Frontiers, Volume 6, Issue 2, Page 921-939, March 2025.
Based on integrated omics, the metabolic regulation networks underlying gradient coloration of ‘Manicure Finger’ grape were constructed at three levels of color‐presenting substances, structural genes, and transcription factors. ABSTRACT ‘Manicure Finger’ grape exhibits gradient coloration during veraison, where the lower part of the skin changes color
Shihan Bao, Jianing Li, Jiaqi Wang, Tian Lan, Mengyuan Wei, Xiangyu Sun, Yulin Fang, Tingting Ma   +7 more
wiley   +1 more source

Anthocyanins Profiling Analysis and RNA-Seq Revealed the Dominating Pigments and Coloring Mechanism in Cyclamen Flowers

Biology, 2022
Pigments in cyclamen (Cyclamen purpurascens) endows flowers with great ornamental and medicinal values. However, little is known about the biosynthetic pathways of pigments, especially anthocyanins, in cyclamen flowers. Herein, anthocyanins profiling and
Demei Xia, Guoqiang He, Kai Wang, Taoyuan Wang, Zhiguo Zhu, Zhaoqian Niu, Gongfa Shi, Guiling Liu   +7 more
doaj   +1 more source