Results 91 to 100 of about 10,638 (220)

Synthesis and Bioevaluation of Chalcones as Broad-Spectrum Antiviral Compounds Against Single-Stranded RNA Viruses

Biomolecules
Chalcones are flavonoid compounds containing an α,β-unsaturated ketone core that are often found in plants and have diverse biological activities including antiviral activity.
Lorael K. M. Kirton, Nasser N. Yousef, Griffith D. Parks, Otto Phanstiel   +3 more
doaj   +1 more source

A Perspective of Soy Isoflavones on Analytical, Biological, and Chemical Attributes

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT This review covers key aspects of soybean (Glycine max), with a particular focus on its isoflavone content and biological properties. Soybeans maintain their position as both a nutraceutical and a pharmaceutical crop, with a broad range of dietary items used worldwide, including soy milk, fermented soy products, and various dietary supplements.
Sristy Suman, Joydeep Chatterjee, Gaurav Joshi, Raj Kumar, Muhammad Wahajuddin   +4 more
wiley   +1 more source

Nutritional quality traits in pea seed: Current knowledge and opportunities for genetic improvement

Annals of Applied Biology, Volume 189, Issue 2, September 2026.
This comprehensive review on nutritional traits in pea (Pisum sativum L.) summarizes the literature on genetic improvement of this highly nutritious and environmentally sustainable crop for different end‐uses. Abstract Pea is a major pulse crop valued for its high protein, carbohydrate, and mineral content, as well as its agronomic role in sustainable ...
Ahmed O. Warsame, Janneke Balk
wiley   +1 more source

Antithrombotic and Anti-Inflammatory Health Promoting Pharmacological Properties of Chalcones and Their Derivatives Against Atherosclerosis and CVD

Sclerosis
Chalcones, a class of flavonoid compounds, are recognized for their unique biological properties, and especially for their antithrombotic, anti-inflammatory, and antioxidant health-promoting properties against inflammation-related disorders.
Valeria Katsoti, Anna Ofrydopoulou, Alexandros Tsoupras   +2 more
doaj   +1 more source

Exploring the Chemical Space Around Protoflavonoids: Synthesis and Antitumor Activity of Protochalcones

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Natural and synthetic protoflavonoids offer potent anticancer properties, but their chemical space remains largely unexplored. This study details the synthesis of eleven p‐hydroxydienone derivatives from chalcone precursors. We evaluated their antiproliferative effects across four human gynecological cancer cell lines.
Tímea Gonda, Kornél Szőri, Ahmed Dhahir Latif, Norbert Kúsz, János Soltész, István Zupkó, Erzsébet Mernyák, Attila Hunyadi   +7 more
wiley   +1 more source

A Review of Natural and Synthetic Chalcones as Anticancer Agents Targeting Topoisomerase Enzymes

Molecules
Cancer remains one of the leading causes of morbidity and mortality worldwide, driving the search for innovative and selective therapeutic agents. Topoisomerases I and II are essential enzymes involved in key cellular processes such as DNA replication ...
François-Xavier Toublet, Aurélie Laurent, Christelle Pouget   +2 more
doaj   +1 more source

Synthesis of the Core Tetracycle of the Spirobiflavonoid Daphnodorin C

European Journal of Organic Chemistry, Volume 29, Issue 30, 12 August 2026.
Core spirotetracycle of daphnodorin C: Oxidative ring contraction of benzofuro[3,2‐b]chromenones affords novel 2,3′‐spirobi[benzofuran]diones, rather than the isomeric spiroketals. The first synthesis of the spirobi[benzofuran]dione core structure of the spirobiflavonoid daphnodorin C is described.
Lukas Heemann, Peter G. Jones, Thomas Lindel   +2 more
wiley   +1 more source

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

Advanced Science, Volume 13, Issue 44, 7 August 2026.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao, Xin Wang, Jing Zhang, Ryan McQuinn, Je Min Lee, Itay Gonda, Ari Feder, Yimin Xu, Baike Wang, Qinghui Yu, Denise M. Tieman, Sanwen Huang, Harry Klee, James J. Giovannoni, Zhangjun Fei   +14 more
wiley   +1 more source

An Overview of Anticancer Chalcones with Apoptosis Inducing Activity

Journal of Mazandaran University of Medical Sciences, 2017
Cancer is a complex and life-threatening disease involving uncontrollable cell proliferation, evading apoptosis, and metastasis. Despite recent developments in cancer chemotherapy, there are no effective broad spectrum anticancer agents that could ...
Hassan Mirzaei, Masoud Keighobadi, Saeed Emami   +2 more
doaj  

Direct Synthesis of 2‐Aryl Quinolone Derivatives via Oxidative Cyclization: Batch Versus Continuous‐Flow

Asian Journal of Organic Chemistry, Volume 15, Issue 8, August 2026.
p‐TsOH·H2O promotes the efficient synthesis of 2‐arylquinolones from readily accessible 2‐aminochalcones under metal‐free conditions. The method also operates in a one‐pot mode from 2‐aminoacetophenones and aldehydes. Translation to continuous flow enables rapid and selective access to either dihydroquinolinones or quinolones by simply controlling the ...
Nian‐Qi Chen, Karthick Govindan, Chia‐Yu Chien, Tamilselvan Duraisamy, Wei‐Yu Lin   +4 more
wiley   +1 more source