Results 121 to 130 of about 17,130 (245)

Multifaceted Suppression of Staphylococcal Virulence Phenotypes: In Vitro Study of a Cellular Status With Reduced Agr Activity and Impaired Biofilm

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Finding of in vitro S. aureus status with reduced Agr activity and impaired biofilm. ABSTRACT Anti‐quorum sensing (QS) therapy has been focused on to reduce the virulence of pathogenic bacteria. However, there is a risk that suppression of the staphylococcal QS Agr system might promote biofilm formation.
Nghi Bao Nguyen, Yuri Ushijima, Raiku Sekiya, Kazuya Morikawa, Le Thuy Thi Nguyen   +4 more
wiley   +1 more source

Atividade antineoplásica in vitro e in vivo da chalcona n9 e seu possível mecanismo de ação [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011As chalconas (1,3-diaril-2-propen-1-onas), formam o núcleo de uma ampla variedade de compostos ...
Neckel, Gecioni Loch
core  

An Overview of Anticancer Chalcones with Apoptosis Inducing Activity

Journal of Mazandaran University of Medical Sciences, 2017
Cancer is a complex and life-threatening disease involving uncontrollable cell proliferation, evading apoptosis, and metastasis. Despite recent developments in cancer chemotherapy, there are no effective broad spectrum anticancer agents that could ...
Hassan Mirzaei, Masoud Keighobadi, Saeed Emami   +2 more
doaj  

Antithrombotic and Anti-Inflammatory Health Promoting Pharmacological Properties of Chalcones and Their Derivatives Against Atherosclerosis and CVD

Sclerosis
Chalcones, a class of flavonoid compounds, are recognized for their unique biological properties, and especially for their antithrombotic, anti-inflammatory, and antioxidant health-promoting properties against inflammation-related disorders.
Valeria Katsoti, Anna Ofrydopoulou, Alexandros Tsoupras   +2 more
doaj   +1 more source

Chalcone‐Incorporated Methyl Cellulose Based Polymer Composite Films With Tunable Optical and Electrical Properties

SPE Polymers, Volume 7, Issue 4, October 2026.
Fabrication and Charecterization of CDMC polymer composite films. ABSTRACT Biodegradable polymer films doped with functional organic chromophores have received much attention owing to their flexible physicochemical properties and diverse applications in optical and electronic devices.
Rashmi, Venkatachalam Hillemane, Ismayil, Latha Jogi, Dhanush Perungodi Chandrashekar   +4 more
wiley   +1 more source

Desenvolvimento e avaliação de sistemas microestruturados contendo chalconas para o tratamento via oral do diabetes melito [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2012.Chalconas sintéticas da série 6-quilonil chalcona (QC2 e QC10) são capazes de reduzir a glicemia de ...
Kleemann, Cristian Rafael
core  

Assessment of synthetic chalcones as cancer chemopreventive agents [PDF]

Cigarette smoking acts as a key source of lung cancer, where the carcinogen malondialdehyde (MDA) produced from cigarette increases the DNA damage.
Jasim, H
core   +1 more source

A Review of Natural and Synthetic Chalcones as Anticancer Agents Targeting Topoisomerase Enzymes

Molecules
Cancer remains one of the leading causes of morbidity and mortality worldwide, driving the search for innovative and selective therapeutic agents. Topoisomerases I and II are essential enzymes involved in key cellular processes such as DNA replication ...
François-Xavier Toublet, Aurélie Laurent, Christelle Pouget   +2 more
doaj   +1 more source

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, Volume 183, Issue 19, Page 5975-5991, October 2026.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, Volume 68, Issue 10, Page 3569-3592, October 2026.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source