Results 121 to 130 of about 10,638 (220)

Licorice-derived prenylated chalcones alleviate knee osteoarthritis via multi-target modulation of PI3K-Akt, MAPK and HIF-1α signaling: an integrative UPLC-Q-TOF-MS/MS, network pharmacology and molecular dynamics study. [PDF]

Front Bioinform
Qian W, Zeng J.
europepmc   +1 more source

Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto, Kelly Lopes Figueira, Raquel Azevedo, Ketlym da Conceição, Ludmila de Ferreira de Almeida Fiuza, Luan dos Santos Vianna, Thiago Apolinário de Moraes, Wagner Alves de Souza Júdice, Maria de Nazaré Correia Soeiro, Jones Limberger   +9 more
wiley   +1 more source

Discovery of Synthetic Imine-Chalcones Targeting Mayaro Virus Replication. [PDF]

Pathogens
Corrêa-Amorim LDS, Rocha NCD, Barboza GKP, Carlos MFLP, Echevarria A, Rabelo VW, Paixão ICNP.   +6 more
europepmc   +1 more source

Toward Sustainable Carbonylation Reactions Enabled by CO Surrogates in Green Solvents

ChemSusChem, Volume 19, Issue 13, 14 July 2026.
Carbonylation reactions offer a sustainable route to valuable carbonyl compounds. This review highlights methodologies that exploit carbonylative coupling to drastically enhance process sustainability, avoiding the direct use of CO through CO surrogates and promoting syntheses in green solvents potentially derived from renewable and sustainable sources.
Francesco Messa, Serena Perrone, Antonio Salomone   +2 more
wiley   +1 more source

Synthesis and Bioactivity Studies of Benzimidazole-Chalcone Hybrids. [PDF]

Molecules
Makgoathana HD, Mthembu ST, Mhlanga TV, Selepe MA, Sonopo MS.   +4 more
europepmc   +1 more source

Cytotoxic Profiling of 3',4',5'-Trimethoxychalcones Reveals Cell-Line-Dependent Cytotoxic Activity: An In Vitro and In Silico Study. [PDF]

Chem Biodivers
Mehandzhiyski AY, Beraich A, Velkov Z, Zaharieva M, Konstantinov S, Batovska D.   +5 more
europepmc   +1 more source

Cross-Species Hepatic Metabolism of the Antileishmanial Chalcone NAT22 Generates Metabolites with Predicted Enhanced Affinity for the Parasite Target cTXNPx. [PDF]

Pharmaceutics
Barreto ARR, Valente APC, Schaeffer E, de Almeida VM, Muzitano MF, Barth T, de Souza AMT, de A A Vieira B, da Silva AM, Santos-Filho OA, Steel PG, Rossi-Bergmann B.   +11 more
europepmc   +1 more source

Cavitand-Mediated Photodimerization of Chalcones: The Effect of Supramolecular Influences and Temperature on Reaction Selectivity. [PDF]

Molecules
Chatterjee J, Pattabiraman M, Chakraborty D, Wysocki AL, Kovacs F.   +4 more
europepmc   +1 more source

Assessment of Cellular Apoptosis Induced by Hydroxychalcones in MCC13 Merkel Cells. [PDF]

Int J Mol Sci
Chmiel M, Włoch A, Potocka-Wojtowicz N, Stompor-Gorący M.   +3 more
europepmc   +1 more source

Design, Synthesis, and Evaluation of New Polyhydroxylated Bis-Chalcones as Potential COX-2 Selective Inhibitors. [PDF]

ChemMedChem
Pereira R, Araújo AN, Ribeiro D, Rufino I, Martinho N, Guedes RC, Silva VLM, Fernandes E.   +7 more
europepmc   +1 more source