Results 131 to 140 of about 25,157 (251)

Exploring 6‐Hydroxy‐3‐Aryl/Heteroarylcoumarins as Promising Candidates Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
New therapies are urgently needed for Chagas disease, and screening of 6‐hydroxy‐3‐aryl/heteroarylcoumarin derivatives identified highly selective compounds with potent activity against T. cruzi. In particular, derivative 1f showed submicromolar trypomastigote potency, dual‐stage activity, and inhibition of amastigote‐to‐trypomastigote differentiation,
C. N. Pereira, L. da Silva Lara, S. da Costa Lanera, T. Pérez de Souza, M. C. de Souza Pereira, G. L. Delogu, M. Silva dos Santos, M. J. Matos   +7 more
wiley   +1 more source

An Overview of Anticancer Chalcones with Apoptosis Inducing Activity

Journal of Mazandaran University of Medical Sciences, 2017
Cancer is a complex and life-threatening disease involving uncontrollable cell proliferation, evading apoptosis, and metastasis. Despite recent developments in cancer chemotherapy, there are no effective broad spectrum anticancer agents that could ...
Hassan Mirzaei, Masoud Keighobadi, Saeed Emami   +2 more
doaj  

Highly Lewis Acidic In Situ‐Generated Boronic Acid Ester: A Practical Catalyst for Hosomi–Sakurai Conjugate Addition, Carbonyl‐Ene Reaction, and Silane‐Mediated Amide Reduction

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
An exceptionally Lewis acidic boronic acid ester, generated in situ from pentafluorophenylboronic acid and tetrabromonaphthalenediol, catalyzes three important chemical transformations at 1–10 mol% loading: the Hosomi–Sakurai allylation of α,β‐unsaturated ketones, intermolecular carbonyl‐ene reactions, and the reductions of tertiary amides to amines ...
Ava Bousselat, Elisabeth Bats, Charbel Alkazzi, Karine Jarsale, Jacques Rouden, Jérôme Blanchet   +5 more
wiley   +1 more source

In vitro and in vivo anticancer studies of 2'-hydroxy chalcone derivatives exhibit apoptosis in colon cancer cells by HDAC inhibition and cell cycle arrest [PDF]

Considering the therapeutic values of bioflavonoids in colon cancer treatment, six 2′-hydroxy chalcones (C1-C6) were synthesized, characterized and screened for in vitro cytotoxicity on human colon carcinoma (HCT116) and African green monkey kidney ...
Biswas, Subhankar, Jayashree, B. S., Kumar, Nitesh, Pande, Aditya Narayan, Rao, C. Mallikarjuna, Reddy, Neetinkumar D.   +5 more
core   +1 more source

The Maize ZmbHLH118 Transcription Factor Regulates Vacuolar Nitrate Loading by the NO3− Transporter ZmCLCa

Advanced Science, Volume 13, Issue 25, 4 May 2026.
In maize, the bHLH transcription factor ZmbHLH118 directly binds to the promoter of ZmCLCa and inhibits its expression. Tonoplast‐localized ZmCLCa mediates NO3− influx into the vacuole to regulate intracellular NO3− homeostasis, modulating nitrate uptake and metabolism, plant growth, and grain yield.
Chaonan Zhang, Elsa Demes‐Causse, Xujian Li, Zhenhui Guo, Hanshu Zhao, Huairong Cao, Yajing Song, Lijun Mu, Kaikai Zhang, Jing Zhang, Zhongtao Jia, Lixing Yuan, Alexis De Angeli, Jingbo Zhang   +13 more
wiley   +1 more source

Királis koronaéterekkel katalizált enantioszelektív szintézisek és ''deracemizációs'' reakciók vizsgálata = Investigation of enantioselective synthesis and deracemization reactions by chiral crownethers [PDF]

, 2008
A monoszacharidokból felépülő királis koronaéterek aszimmetrikus indukciót képesek kifejteni bizonyos reakciókban, ha királis fázistranszfer katalizátorként alkalmazzuk azokat.
Bakó, Péter, Bakó, Tibor, Keglevich, György, Parlagh, Gyula, Szöllősy, Áron, Toke, László   +5 more
core  

Photophysics of Biological and Biomimetic Sunscreen Molecules

ChemPhotoChem, Volume 10, Issue 5, May 2026.
Recent photochemical and photophysical research into natural and nature‐inspired UV filter molecules is reviewed, with a focus on the application of these systems in next‐generation sunscreens. The results of time‐resolved UV spectroscopy experiments and theoretical studies are discussed.
Michael Hymas, Vasilios G. Stavros
wiley   +1 more source

Homoisoflavonoids—From Natural Specificity and Biosynthesis to Precision Health‐Promoting Mechanisms

Food Frontiers, Volume 7, Issue 3, May 2026.
Homoisoflavonoids are rare flavonoids with a unique bi‐aromatic oxygen‐heterocyclic structure. This review synthesizes their structure–activity relationships in anti‐inflammatory, hypoglycemic, and anticancer contexts. By highlighting their specific natural distribution and outlining biosynthetic pathways, it provides a conceptual framework and ...
Jing Zhang, Han Chen, Jinping Si, Zhigang Han, Xinfeng Zhang   +4 more
wiley   +1 more source

Effect of pH on recovery efficiency and anthocyanin composition of Clitoria ternatea extracts with application as lipid antioxidants in food preservation

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
pH significantly affects the extraction efficiency of TPC TAC and the extracted anthocyanin components. pH 3 and pH 7 yield the highest extraction efficiency and antioxidant activity. Extracts at pH 7 are suitable as blue color additives for neutral pH foods and as good antioxidants for fat‐containing gummies.
Kha Duyen Nguyen, Thi Thu Tra Tran, Ngọc Anh Le, Thi Anh Dao Dong   +3 more
wiley   +1 more source

Direct synthesis, characterization, in vitro and in silico studies of simple chalcones as potential antimicrobial and antileishmanial agents

Royal Society Open Science
Chalcone represents a vital biosynthetic scaffold owing to its numerous therapeutic effects. The present study was intended to synthesize 17 chalcone derivatives (3a–q) by direct coupling of substituted acetophenones and benzaldehyde.
Haroon ur Rashid, Sherwali Khan, Irum, Asad Khan, Nasir Ahmad, Tanzeel Shah, Khalid Khan   +6 more
doaj   +1 more source