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Identification of Food-Derived Electrophilic Chalcones as Nrf2 Activators Using Comprehensive Virtual Screening Techniques. [PDF]
Antioxidants (Basel)Bai B +8 more
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Current Medicinal Chemistry, 1999
This review outlines the different bioactivities of a variety of chalcones. The cytotoxic, anticancer, chemopreventative and mutagenic properties of a number of chalcones are described followed by an account of various of these unsaturated ketones as antimicrobial agents.
J R, Dimmock +3 more
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This review outlines the different bioactivities of a variety of chalcones. The cytotoxic, anticancer, chemopreventative and mutagenic properties of a number of chalcones are described followed by an account of various of these unsaturated ketones as antimicrobial agents.
J R, Dimmock +3 more
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Tetrahedron, 1975
Abstract 2′-hydroxychalcone dibromides substituted by OMe in the 6′-position are found to yield little or no aurone in dilute aqueous ethanolic potassium hydroxide. The proportion of aurone to flavone in their products parallels increasing hydroxide concentration.
J.A. Donnelly, H.J. Doran
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Abstract 2′-hydroxychalcone dibromides substituted by OMe in the 6′-position are found to yield little or no aurone in dilute aqueous ethanolic potassium hydroxide. The proportion of aurone to flavone in their products parallels increasing hydroxide concentration.
J.A. Donnelly, H.J. Doran
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Anticancer activities of novel chalcone and bis-chalcone derivatives
Bioorganic & Medicinal Chemistry, 2006A series of novel chalcones and bis-chalcones containing boronic acid moieties has been synthesized and evaluated for antitumor activity against the human breast cancer MDA-MB-231 (estrogen receptor-negative) and MCF7 (estrogen receptor-positive) cell lines and against two normal breast epithelial cell lines, MCF-10A and MCF-12A.
Aneta, Modzelewska +5 more
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STEM CELLS, 1994
On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13 ...
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On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13 ...
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Stereoselectivity of chalcone isomerase with chalcone derivatives: a computational study
Journal of Molecular Modeling, 2013Chalcone isomerase (CHI) catalyzes the intramolecular cyclization of chalcones into flavonoids. The activity of CHI is essential for the biosynthesis of flavonoids precursors of floral pigments and phenylpropanoid plant defense compounds. In the present study, we explored the detailed binding structures and binding free energies for two different ...
Yuan, Yao, Hui, Zhang, Ze-Sheng, Li
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Coupling–Isomerization Synthesis of Chalcones
Chemistry – A European Journal, 2006AbstractThe Sonogashira coupling of electron‐deficient (hetero)aryl halides 1 and (hetero)aryl or alkenyl 1‐propargyl alcohols 2 does not terminate at the stage of the expected internal propargyl alcohols, but rather gives rise to the formation of α,β‐unsaturated ketones 3 with a variety of acceptor substituents.
Roland U, Braun +2 more
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Antimalarial Activity of Ferrocenyl Chalcones.
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Wu, X., Wilairat, P., Go, M.-L.
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