Results 81 to 90 of about 36,394 (277)

Design and Synthesis of Pyridyl and 2-Hydroxyphenyl Chalcones with Antitubercular Activity

Molecules
A focussed library of pyridyl and 2-hydroxyphenyl chalcones were synthesized and tested for growth inhibitory activity against Mycobacterium tuberculosis H37Rv, and normal and cancer breast cell lines.
Kelphina Aziafor, Ketan Ruparelia, Brandon Moulds, Mire Zloh, Tanya Parish, Federico Brucoli   +5 more
doaj   +1 more source

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

University teaching of mass spectrometry as a key practical technique within the context of a fully integrated, spiral curriculum

Rapid Communications in Mass Spectrometry, EarlyView.
Rationale Mass spectrometry (MS) is introduced to high school students in the UK in many pre‐university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their studies.
Andrew F. Worrall, Craig D. Campbell, Megan O. Midson, Malcolm I. Stewart   +3 more
wiley   +1 more source

Rapid Structural Analysis of Natural Products Using MicroED

Small, EarlyView.
The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin, Orel Paz, Johan Unge, Tamir Gonen   +3 more
wiley   +1 more source

CHALCONES: THE PROMISING COMPOUNDS TO PROVIDE NEW WAYS FOR CANCER TREATMENT [PDF]

, 2014
Chalcones (1,3-diphenylpropen-1-ones), a biosynthetic product of the shikimate pathway, belonging to flavanoid family are precursors of open chain flavonoids and isoflavonoids, which are abundant in edible plants.
Retno, Arianingrum
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Antimicrobial Evaluation and Synthesis of Some Phenylpyrazolo benzothiazolo quinoxaline Derivatives

E-Journal of Chemistry, 2009
2,3-Diphenyl quinoxaline (SI) was fused with 2-amino benzothiazoles (SII) by a methylene bridge, which was then allowed for acetylation. The acetylated product (SIV) was made to react with different aromatic aldehydes to give chalcones (SV1-SV5 ...
CH. Sridevi, K. Balaji, A. Naidu, R. Sudhakaran   +3 more
doaj   +1 more source

A novel sulfur‐containing photoinitiator based on benzophenone derivatives for rapid photopolymerization

Smart Molecules, EarlyView.
This study develops a series of unimolecular photoinitiators, BP‐S1‐5, by incorporating hydrogen‐donating groups into a benzophenone framework. This method reduces the reliance on co‐initiators, and enables BP‐S1‐5 with efficient photoinitiation and excellent molding capability.
Yu Li, Wenzheng Li, Saihe Yang, Lu Li, Shikun Song, Yuting Tang, Han Han, Zhenyue Duan, Yangyang Xin, Jiangli Fan, Pengzhong Chen, Xiaojun Peng   +11 more
wiley   +1 more source

Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones

Pharmacology & Pharmacy, 2011
A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. A novel series of pyrazolicchalcones (5a-c) have been synthesized by the reaction of respective chalcones (4a-c) and hydrazine hydrate.
Tan Nhut Doan, Dao Thanh Tran
openaire   +2 more sources

Mechanofluorochromism (MFC) of Donor–π–Acceptor (D–π–A)‐Type Fluorescent Dyes

The Chemical Record, EarlyView.
Mechanofluorochromism (MFC) is a photophysical phenomenon that induces changes in fluorescent colors as well as colors of organic fluorescent dyes in the solid‐state by external mechanical stimuli. In this Personal Account, we offer an insight into the mechanism for the expression of MFC and present a direction in the molecular design toward creating D–
Yousuke Ooyama
wiley   +1 more source

Synthesis and characterization of phosphine substituted organometallic chalcones [PDF]

, 2014
The current focus in organometallic chalcones is based upon their synthesis, eloectrochemical properties, diverse biological behavior and their facet towards a new field “bioorganometallics’’ concerning both organometallic and coordination chemistry ...
Betal, J
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