Results 121 to 130 of about 4,322,380 (297)

Advancing microbiome research in Māori populations: insights from recent literature exploring the gut microbiomes of underrepresented and Indigenous peoples

mSystems
The gut microbiome plays vital roles in human health, including mediating metabolism, immunity, and the gut-brain axis. Many ethnicities remain underrepresented in gut microbiome research, with significant variation between Indigenous and non-Indigenous ...
Ella T. Silk, Simone B. Bayer, Meika Foster, Nicole C. Roy, Michael W. Taylor, Tommi Vatanen, Richard B. Gearry   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Design and conduct of a full diet-controlled, parallel, 2-week residential trial for diabetes prevention without weight loss in Asian Chinese and European Caucasian adults with prediabetes: the New Zealand SYNERGY study

Frontiers in Nutrition
BackgroundThe causal underpinning of increased metabolic risk and previously observed dichotomous plasma metabolome in Asian Chinese vs. European Caucasian remains undetermined and may be hypothesised as attributed to ethnicity (genetic background ...
Ivana R. Sequeira-Bisson, Ivana R. Sequeira-Bisson, Ivana R. Sequeira-Bisson, Karl Fraser, Karl Fraser, Kok Hong Leiu, Kok Hong Leiu, Jack Penhaligan, Jack Penhaligan, Aidan Joblin-Mills, Aidan Joblin-Mills, Lindsay D. Plank, Rinki Murphy, Rinki Murphy, Rinki Murphy, Rinki Murphy, Michael W. Taylor, Michael W. Taylor, Michael W. Taylor, Olivier Gasser, Olivier Gasser, Denise M. Conroy, Denise M. Conroy, Yannan Jiang, Louise W. W. Lu, Louise W. W. Lu, Sally D. Poppitt, Sally D. Poppitt, Sally D. Poppitt, Sally D. Poppitt, Jennifer L. Miles-Chan, Jennifer L. Miles-Chan, Jennifer L. Miles-Chan   +32 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Facing the challenges of global agriculture today: What can we do about drought?

Frontiers in Physiology, 2013
Philippe eMonneveux, Antonia eOkono, Jean-Marcel eRibaut   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Challenge Program on Water and Food: Volta Basin Development Challenge Management of Rainwater and Small Reservoir for multiple uses, 2012 Annual Reflection Report [PDF]

, 2013
As a program designed for bridging research to development outcome, the CPWF considers regular reflection, learning and adaptive management as crucial elements in the implementation of the basin programs. Reflection implies that the project teams and key
CGIAR Challenge Program on Water and Food
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