Results 111 to 120 of about 3,527,028 (317)

Challenge

, 1991
BACKGROUND INFORMATION The Morehouse Research Institute (MRI), established in 1990, promotes an interdisciplinary program of scholarship. It is designed to generate, disseminate, and exchange information which can guide public policy and programs ...
Mukenge, Ida Rousseau
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

GnRH challenge protocol [PDF]

, 2013
Protocol for administering a GnRH challenge to a songbird. This procedure injects a bird with a known concentration of gonadotropin releasing hormone and measures the amount of testosterone produced in ...
Joe Casto, Joel McGlothlin, Ellen Ketterson
core  

Dietary patterns influencing the human colonic microbiota from infancy to centenarian age: a narrative review

Frontiers in Nutrition
Our dietary choices not only affect our body but also shape the microbial community inhabiting our large intestine. The colonic microbiota strongly influences our physiology, playing a crucial role in both disease prevention and development.
Vitor Geniselli da Silva, Vitor Geniselli da Silva, Nicole Clémence Roy, Nicole Clémence Roy, Nicole Clémence Roy, Nick William Smith, Clare Wall, Clare Wall, Jane Adair Mullaney, Jane Adair Mullaney, Jane Adair Mullaney, Warren Charles McNabb, Warren Charles McNabb   +12 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Mathematical models of the colonic microbiota: an evaluation of accuracy using in vitro fecal fermentation data

Frontiers in Nutrition
Traditional approaches for studying diet-colonic microbiota interactions are time-consuming, resource-intensive, and often hindered by technical and ethical concerns.
Vitor Geniselli da Silva, Vitor Geniselli da Silva, Nick William Smith, Jane Adair Mullaney, Jane Adair Mullaney, Jane Adair Mullaney, Nicole Clémence Roy, Nicole Clémence Roy, Nicole Clémence Roy, Clare Wall, Clare Wall, Warren Charles McNabb, Warren Charles McNabb   +12 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

AN IRREGULAR CHALLENGE

Revista de Lenguas para Fines Específicos, 2005
En este trabajo se presentan diferentes estrategias en la enseñanza de una lengua extranjera. Ellos se basan en una metodología audiovisual. Por un lado, el alumno siente el lenguaje vivo desde el principio, y de forma paralela, desempeña un papel activo papel en su aprendizaje.
openaire   +4 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source