Results 101 to 110 of about 3,527,028 (317)

The Challenge of Challenges [PDF]

open access: yesGerman Law Journal, 2020
Finck, M., Witte, F.
openaire   +3 more sources

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Challenge

open access: yes, 2008
Sports and extracurricular activities are pervasive features in American higher education with potential for major impacts on student motivation, development, and success.
Mukenge, Ida Rousseau
core  

Challenge Program on Water and Food: Volta Basin Development Challenge Management of Rainwater and Small Reservoir for multiple uses, 2012 Annual Reflection Report [PDF]

open access: yes, 2013
As a program designed for bridging research to development outcome, the CPWF considers regular reflection, learning and adaptive management as crucial elements in the implementation of the basin programs. Reflection implies that the project teams and key
CGIAR Challenge Program on Water and Food
core  

How universal are universal pre-school health and developmental screens? Evidence from New Zealand’s Integrated Data Infrastructure (IDI)

open access: yesInternational Journal of Population Data Science, 2018
In New Zealand, children participate in a pre-school screen to ensure they are reaching key developmental milestones and not having significant physical, emotional or behavioural issues. This pre-school screen is called the Before School Check (B4SC) and
Richard Audas
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Coordination et Changement [PDF]

open access: yes, 2013
The project will orient, align and integrate the four research for development projects (V1 -V4) that have been designed to respond to the basin development challenge in order to contribute to poverty reduction and improved livelihood resilience in the ...
CGIAR Challenge Program on Water and Food
core  

Predicting the use Literacy Interventions Using a Pre-School Health and Developmental Screen: Evidence from New Zealand’s Integrated Data Infrastructure (IDI)

open access: yesInternational Journal of Population Data Science, 2018
Early literacy attainment is a key progression towards advanced learning. All New Zealand schools offer interventions for children who are farthest from standard in literacy, although these interventions typically do not commence until the child has been
Richard Audas
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

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