Results 101 to 110 of about 4,322,380 (297)

How universal are universal pre-school health and developmental screens? Evidence from New Zealand’s Integrated Data Infrastructure (IDI)

International Journal of Population Data Science, 2018
In New Zealand, children participate in a pre-school screen to ensure they are reaching key developmental milestones and not having significant physical, emotional or behavioural issues. This pre-school screen is called the Before School Check (B4SC) and
Richard Audas
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

AN IRREGULAR CHALLENGE

Revista de Lenguas para Fines Específicos, 2005
En este trabajo se presentan diferentes estrategias en la enseñanza de una lengua extranjera. Ellos se basan en una metodología audiovisual. Por un lado, el alumno siente el lenguaje vivo desde el principio, y de forma paralela, desempeña un papel activo papel en su aprendizaje.
openaire   +4 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Dietary patterns influencing the human colonic microbiota from infancy to centenarian age: a narrative review

Frontiers in Nutrition
Our dietary choices not only affect our body but also shape the microbial community inhabiting our large intestine. The colonic microbiota strongly influences our physiology, playing a crucial role in both disease prevention and development.
Vitor Geniselli da Silva, Vitor Geniselli da Silva, Nicole Clémence Roy, Nicole Clémence Roy, Nicole Clémence Roy, Nick William Smith, Clare Wall, Clare Wall, Jane Adair Mullaney, Jane Adair Mullaney, Jane Adair Mullaney, Warren Charles McNabb, Warren Charles McNabb   +12 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Mathematical models of the colonic microbiota: an evaluation of accuracy using in vitro fecal fermentation data

Frontiers in Nutrition
Traditional approaches for studying diet-colonic microbiota interactions are time-consuming, resource-intensive, and often hindered by technical and ethical concerns.
Vitor Geniselli da Silva, Vitor Geniselli da Silva, Nick William Smith, Jane Adair Mullaney, Jane Adair Mullaney, Jane Adair Mullaney, Nicole Clémence Roy, Nicole Clémence Roy, Nicole Clémence Roy, Clare Wall, Clare Wall, Warren Charles McNabb, Warren Charles McNabb   +12 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

2017 Sustainable LA Grand Challenge Research Symposium Program [PDF]

, 2017
On May 17, 2017, Sustainable LA Grand Challenge (SLA GC) hosted their first symposium showcasing cutting-edge research toward the goal of 100% renewable energy, 100% locally sourced water, and enhanced ecosystem and human health in Los Angeles County by ...
Sustainable LA Grand Challenge
core   +1 more source