Results 81 to 90 of about 4,322,380 (297)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Wellcome Open ResearchBackground The pandemic of antimicrobial resistance (AMR) will only be mitigated by policy action and innovation and importantly, supported by local and community action. Last year (2024) with the United Nations General Assembly high level meeting on AMR
Marc Mendelson +5 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
South Carolina Youth Challenge Academy Wellness Policy [PDF]
, 2023 The South Carolina Youth Challenge Academy (SCYCA) Wellness Committee recognizes that cadet wellness and proper nutrition are related to their physical wellbeing, growth, development, and readiness to learn.
South Carolina Youth Challenge Academy
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MetabolitesBiological samples of lipids and metabolites degrade after extensive years in −80 °C storage. We aimed to determine if associated multivariate models are also impacted.
Aidan Joblin-Mills +5 more
doaj +1 more source
Scientific Reports, 2017 House dust mite (HDM) allergy is a predominant cause for perennial allergic rhinitis (AR) in Europe. We recently reported that circulating erythrocyte numbers decrease after airway allergen challenge in a murine asthma model and in grass-pollen ...
Galateja Jordakieva +6 more
doaj +1 more source
BMC Infectious Diseases, 2019 Background Multi-drug resistant Tuberculosis (MDR-TB) is a strain of Mycobacterium tuberculosis that is resistant to at least Rifampicin and Isoniazid drugs. The treatment success rate for MDR-TB cases is lower than for drug susceptible TB. Globally only
Teklu Molie +11 more
doaj +1 more source
The Challenge of Challenges [PDF]
German Law Journal, 2020 Finck, M., Witte, F.
openaire +3 more sources
Challenges for education [PDF]
Frontiers in Neurology, 2010 The topic of education has been incorporated into most mission statements at academic institutions, organizations and professional societies, in fact it would be difficult to identify one in which it was absent. Yet, what does it mean, how do we achieve it and is it really viewed as an equal partner in the tripartite mission of clinical care, research,
openaire +3 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source