Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Business model innovation: Creating value in times of change [PDF]
We highlight business model innovation as a way for general managers and entrepreneurs to create and appropriate value, especially in times of economic change.
Amit, Raphael, Zott, Christoph
core
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
PREPARING FOR SUCCESS IN THE AGRIBUSINESS MARKET PLACE [PDF]
With the dramatic changes occurring in the agricultural industries, it is critical to develop and maintain competencies that will enhance one's competitive position in this rapidly evolving market.
Akridge, Jay T. +2 more
core +1 more source
Back to the future: the Brazilian Journal of Psychiatry embraces change and innovation. [PDF]
Braz J PsychiatryBrunoni AR, Nardi AE.
europepmc +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
The CGIAR at a Crossroads: Assessing the role of international agricultural research in poverty alleviation from an innovation systems perspective [PDF]
Globalization, technical change and migration are changing the dynamics of poverty and food production. These factors, combined with a better understanding of the nature of complex processes, are also changing the nature of scientific research, the roles
Ekboir, Javier M.
core +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Governance of Environment-Enhancing Technical change - past experiences and suggestions for improvement [PDF]
There is much talk about environmental policies being faulty. Past policies are being criticisedfor failing to achieve environmental goals (the environmentalist complaint), for being overlyexpensive (the industrialist complaint) and for failing to ...
Kemp,Rene
core +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source