Results 131 to 140 of about 2,639,548 (308)

Demographic change and industry-specific innovation patterns in Germany [PDF]

open access: yes
In Germany, a thread to growth is perceived from demographic change. Demographic change means that a population is aging with the perspective of shrinking.
Golo Henseke, Thusnelda Tivig
core  

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

La recherche pédagogique collaborative : une voie singulière pour le développement de pratiques pédagogiques alternatives

open access: yesRecherches en Éducation
This paper discusses a research approach designed to study the development of pedagogical practices which break with traditional pedagogies through a collaborative framework. It is illustrated by a research project carried out in a REP+ primary school on
Laurent Lescouarch, Marie Vergnon
doaj   +1 more source

The role of patent protection in (clean/green) technology transfer. [PDF]

open access: yes
Global climate change mitigation will require the development and diffusion of a large number and variety of new technologies. How will patent protection affect this process?
Bronwyn H. Hall, Christian Helmers
core  

Enabling Creativity and Innovation [PDF]

open access: yes, 2012
[Excerpt] The capacity to harness intellectual and social capital and to convert it into novel and useful things has become the critical organizational requirement of the age.
Serrat, Olivier
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

AN APPROACH TO THE MEASUREMENT OF TECHNOLOGICAL CHANGE BASED ON THE INTENSITY OF INNOVATION [PDF]

open access: yes
The economics of innovation presents a lot of taxonomies of innovation. This research introduces the scale of innovative intensity (SIIN) based on a meta-taxonomy that subsume other, less comprehensive taxonomy.
Mario Coccia
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Climate change and radical energy innovation: the policy issues [PDF]

open access: yes
Although the impacts of greenhouse gas build-up remain uncertain, they have the potential to be very serious and possibly catastrophic. If the outcomes are serious then neither improving energy efficiency nor adaptation policies will cope with the ...
Keith Smith
core  

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