Results 261 to 270 of about 1,327,189 (298)
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Current Topics in Medicinal Chemistry, 2011
Transient Receptor Potential (TRP) cation channels participate in several processes of vital importance in cell and organism physiology, and have been demonstrated to participate in the detection of sensory stimuli. The thermo TRP's reviewed: TRPV1 (vanilloid 1), TRPM8 (melastatin 8) and TRPA1 (ankyrin-like 1) are known to integrate different chemical ...
Andrés, Nieto-Posadas +2 more
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Transient Receptor Potential (TRP) cation channels participate in several processes of vital importance in cell and organism physiology, and have been demonstrated to participate in the detection of sensory stimuli. The thermo TRP's reviewed: TRPV1 (vanilloid 1), TRPM8 (melastatin 8) and TRPA1 (ankyrin-like 1) are known to integrate different chemical ...
Andrés, Nieto-Posadas +2 more
openaire +2 more sources
Current Opinion in Pharmacology, 2001
Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
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Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
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Potassium channels and their evolving gates
Nature, 1994Potassium channels allow potassium ions to flow across the membrane and play a key role in maintaining membrane potential. Recent research has begun to reveal how these channels transport potassium in preference to other ions, how their activity is controlled, and how they are related to other channels.
L Y, Jan, Y N, Jan
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IEEE Transactions on Nanobioscience, 2005
Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the ...
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Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the ...
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Angewandte Chemie International Edition, 2001
Ion channels are at the heart of many biological processes such as nerve activity and muscle contraction. How are their impressive ion selectivity and highly specialized gating brought about? In recent years, X-ray crystallography and high-resolution electron microscopy, as well as photo-affinity labeling and site-specific mutagenesis techniques in ...
Ferdinand, Hucho, Christoph, Weise
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Ion channels are at the heart of many biological processes such as nerve activity and muscle contraction. How are their impressive ion selectivity and highly specialized gating brought about? In recent years, X-ray crystallography and high-resolution electron microscopy, as well as photo-affinity labeling and site-specific mutagenesis techniques in ...
Ferdinand, Hucho, Christoph, Weise
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Science's STKE, 2003
Ion channels and the electrical properties they confer on cells are involved in every human characteristic that distinguishes us from the stones in a field. Every perception, thought, movement, and heartbeat depends on electrical signals generated by the activity of ion channels.
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Ion channels and the electrical properties they confer on cells are involved in every human characteristic that distinguishes us from the stones in a field. Every perception, thought, movement, and heartbeat depends on electrical signals generated by the activity of ion channels.
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Biophysics of BK Channel Gating
2016BK channels are universal regulators of cell excitability, given their exceptional unitary conductance selective for K(+), joint activation mechanism by membrane depolarization and intracellular [Ca(2+)] elevation, and broad expression pattern. In this chapter, we discuss the structural basis and operational principles of their activation, or gating ...
A, Pantazis, R, Olcese
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Gating of sodium and potassium channels
The Journal of Membrane Biology, 1985Voltage-dependent conductances play a fundamental role in the generation and propagation of the action potential. Hodgkin and Huxley (1952c) made a complete description of the membrane currents underlying the generation of the impulse. Their description introduced the concepts of separate pathways for sodium and potassium (today called Na and K ...
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Bimodal gating of the Na+ channel
Trends in Neurosciences, 1994Inactivation of voltage-gated ion channels, whether they are selective for Na+, K+ or Ca2+, probably never involves their total closure, and some flow of ion current persists if large enough test pulses are applied. Incomplete inactivation was first reported for the Na+ channels of the squid giant axon, but has since been observed in other types of ...
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Gating in Sodium Channels of Nerve
Annual Review of Physiology, 1976During the period 1937-1952 the study of electrical excitability mechanisms in axons matured from discoveries of membrane impedance changes to a complete kinetic description of ionic permeability changes in the squid giant axon (35). There followed a period of relative stagnation while the results on squid were rechecked and new voltage clamp methods ...
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