Results 251 to 260 of about 1,327,189 (298)
Membrane lipid modulations by methyl-β-cyclodextrin uncouple the Drosophila light-activated phospholipase C from TRP and TRPL channel gating. [PDF]
J Biol ChemGutorov R, Katz B, Peters M, Minke B.
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IEEE Transactions on Nanobioscience, 2005
Ligand-gated ion channels (LGICs) are fast-responding channels in which the receptor, which binds the activating molecule (the ligand), and the ion channel are part of the same nanomolecular protein complex. This paper will describe the properties and functions of the nicotinic acetylcholine LGIC superfamily, which plays a critical role in the fast ...
Barry, P. H., Lynch, J. W.
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Ligand-gated ion channels (LGICs) are fast-responding channels in which the receptor, which binds the activating molecule (the ligand), and the ion channel are part of the same nanomolecular protein complex. This paper will describe the properties and functions of the nicotinic acetylcholine LGIC superfamily, which plays a critical role in the fast ...
Barry, P. H., Lynch, J. W.
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Pflügers Archiv - European Journal of Physiology, 2009
The aminoacid sequences of CNG and K(+) channels share a significant sequence identity, and it has been suggested that these channels have a common ancestral 3D architecture. However, K(+) and CNG channels have profoundly different physiological properties: indeed, K(+) channels have a high ionic selectivity, their gating strongly depends on membrane ...
MAZZOLINI M +3 more
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The aminoacid sequences of CNG and K(+) channels share a significant sequence identity, and it has been suggested that these channels have a common ancestral 3D architecture. However, K(+) and CNG channels have profoundly different physiological properties: indeed, K(+) channels have a high ionic selectivity, their gating strongly depends on membrane ...
MAZZOLINI M +3 more
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Gate-to-channel shorts in BiCMOS logic gates
Proceedings of IEEE VLSI Test Symposium, 2002This paper describes the effects of gate-to-channel breakdown on the operation of BiCMOS logic gates. Both the static and dynamic behaviours of the gates are examined. The influence of the position of the defect within the channel is noted. Expressions for the logic levels and the quiescent current of an inverter in the presence of defects are ...
C.-J. Chen, Samiha Mourad
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Gating Mechanisms of Voltage-Gated Proton Channels
Annual Review of Biochemistry, 2015Hv1 is a voltage-gated proton-selective channel that plays critical parts in host defense, sperm motility, and cancer progression. Hv1 contains a conserved voltage-sensor domain (VSD) that is shared by a large family of voltage-gated ion channels, but it lacks a pore domain.
Yasushi, Okamura +2 more
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Current Opinion in Pharmacology, 2015
Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
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Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
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Science, 2016
Structural Biology The type 2 ryanodine receptor (RyR2) controls the release of calcium ions from the sarcoplasmic reticulum in cardiac cells—the initiating step in cardiac muscle contraction. Mutations in RyR2 are associated with cardiac diseases. Peng et al.
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Structural Biology The type 2 ryanodine receptor (RyR2) controls the release of calcium ions from the sarcoplasmic reticulum in cardiac cells—the initiating step in cardiac muscle contraction. Mutations in RyR2 are associated with cardiac diseases. Peng et al.
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The gating of the CFTR channel
Cellular and Molecular Life Sciences, 2016Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel expressed in the apical membrane of epithelia. Mutations in the CFTR gene are the cause of cystsic fibrosis. CFTR is the only ABC-protein that constitutes an ion channel pore forming subunit.
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Electromagnetic gating in ion channels
Journal of Theoretical Biology, 1992There have been many attempts to develop a theoretical explanation of the phenomena of electromagnetic field interactions with biological systems. None of the reported efforts have been entirely successful in accounting for the observed experimental results, in particular with respect to the reports of interactions between extremely low frequency (ELF)
B R, McLeod, A R, Liboff, S D, Smith
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Channel gating of NMDA receptors
Physiology & Behavior, 2002Glutamate receptors specifically activated by N-methyl-D-aspartate (NMDA receptors) are ion channels that play multiple fundamental roles in the physiology of vertebrate nervous systems. The mechanisms that control the opening and closing, or gating, of the channel of NMDA receptors are among the most basic determinants of receptor function, and yet ...
Anqi, Qian, Jon W, Johnson
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