Results 31 to 40 of about 1,327,189 (298)

Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the alphaM2-cap. [PDF]

PLoS ONE, 2008
Gating of nicotinic acetylcholine receptors from a C(losed) to an O(pen) conformation is the initial event in the postsynaptic signaling cascade at the vertebrate nerve-muscle junction.
Pallavi A Bafna, Prasad G Purohit, Anthony Auerbach   +2 more
doaj   +1 more source

Structural basis of human Slo2.2 channel gating and modulation

Cell Reports, 2023
Summary: The sodium-activated Slo2.2 channel is abundantly expressed in the brain, playing a critical role in regulating neuronal excitability. The Na+-binding site and the underlying mechanisms of Na+-dependent activation remain unclear.
Jiangtao Zhang, Shiqi Liu, Junping Fan, Rui Yan, Bo Huang, Feng Zhou, Tian Yuan, Jianke Gong, Zhuo Huang, Daohua Jiang   +9 more
doaj   +1 more source

Mechanistic Insight into Subunit Stoichiometry for KIR Channel Gating: Ligand Binding, Gating, Binding-Gating Coupling, Coordination, and Cooperativity [PDF]

, 2005
Ligand-gated ion channels couple intra- and extracellular chemical signals to cellular excitability. In response to a specific ligand, these channels change their permeability to certain ions by opening or closing their ion conductive pathway, a ...
Wang, Runping
core   +1 more source

Single-channel kinetics of BK (Slo1) channels

Frontiers in Physiology, 2015
Single-channel kinetics has proven a powerful tool to reveal information about the gating mechanisms that control the opening and closing of ion channels. This introductory review focuses on the gating of large conductance Ca2+- and voltage-activated K+
Yanyan eGeng, Karl L. Magleby
doaj   +1 more source

FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6 [PDF]

, 2012
Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca2+-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel gating.
Mano Sitsapesan (182017), Tsaneva-Atanasova, Krasimira, Samantha J Pitt, Pitt Samantha J., Zaccai, N, Krasimira Tsaneva-Atanasova (144624), Sitsapesan, Rebecca, Tsaneva-Atanasova, KT, Pitt, SJ, Stephen O'Neill (182027), Zaccai Nathan R., Tsaneva-Atanasova Krasimira, Sitsapesan Rebecca, O'Neill Stephen, Galfre, Elena, Pitt, Samantha Jane, Nathan R. Zaccai (182021), Venturi Elisa, Sitsapesan, Mano, Mano Sitsapesan, Galfré Elena, Rebecca Sitsapesan (182033), Sitsapesan Mano, Rebecca Sitsapesan, Venturi, E, Galfré, E, Samantha J. Pitt (182004), Tsaneva-Atanasova, K, Stephen O'Neill, Elisa Venturi, Elena Galfré, Elena Galfré (182000), Elisa Venturi (182009), Zaccai, NR, O'Neill, Stephen, Nathan R Zaccai, Sitsapesan, R, O'Neill, S, Krasimira Tsaneva-Atanasova, Venturi, Elisa, Zaccai, Nathan R, Sitsapesan, M   +41 more
core   +1 more source

Slow‐channel myasthenia due to novel mutation in M2 domain of AChR delta subunit

Annals of Clinical and Translational Neurology, 2019
Objective To characterize the molecular and phenotypic basis of a severe slow‐channel congenital myasthenic syndrome (SCCMS). Methods Intracellular and single‐channel recordings from patient endplates; alpha‐bungarotoxin binding studies; direct ...
Xin‐Ming Shen, Margherita Milone, Hang‐Long Wang, Brenda Banwell, Duygu Selcen, Steven M. Sine, Andrew G. Engel   +6 more
doaj   +1 more source

Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits NaV1.8 via Interactions With the DI Voltage Sensor and DII Pore Module

Frontiers in Pharmacology, 2022
Voltage-gated sodium channel NaV1.8 regulates transmission of pain signals to the brain. While NaV1.8 has the potential to serve as a drug target, the molecular mechanisms that shape NaV1.8 gating are not completely understood, particularly mechanisms ...
Kiran George, Diego Lopez-Mateos, Diego Lopez-Mateos, Tarek Mohamed Abd El-Aziz, Tarek Mohamed Abd El-Aziz, Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Hong Bao, Syed Raza, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Matthew P. Rowe, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy, Ashlee H. Rowe, Ashlee H. Rowe   +18 more
doaj   +1 more source

FKBP12.6 activates RyR1 : investigating the amino acid residues critical for channel modulation [PDF]

, 2014
Funding: British Heart FoundationWe have previously shown that FKBP12 associates with RyR2 in cardiac muscle and that it modulates RyR2 function differently to FKBP12.6.
Richard B. Sessions, Elisa Venturi, O'Brien, Fiona, Rebecca Sitsapesan, Fiona O’Brien, Bellamy, Stuart, Pitt, Samantha J, Stuart Bellamy, Sitsapesan, Rebecca, Sessions, Richard B., Elena Galfré, Pitt, Samantha J., Galfre, Elena, O’Brien, Fiona, Samantha J. Pitt, Sessions, Richard B, Venturi, Elisa   +16 more
core   +1 more source

Inter-subunit interactions across the upper voltage sensing-pore domain interface contribute to the concerted pore opening transition of Kv channels. [PDF]

PLoS ONE, 2013
The tight electro-mechanical coupling between the voltage-sensing and pore domains of Kv channels lies at the heart of their fundamental roles in electrical signaling.
Tzilhav Shem-Ad, Orr Irit, Ofer Yifrach
doaj   +1 more source

The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel [PDF]

, 2011
Opening of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated by direct binding of cyclic nucleotides to a cyclic nucleotide-binding domain (CNBD) in the C-terminus. Here, we show for the first time that in the HCN2 channel
Biel Martin, Biel, Martin, Hammelmann, Verena, Hofmann, Franz, Michalakis, Stylianos, Xiangang Zong, Hammelmann Verena, Zong Xiangang, Stylianos Michalakis, Martin Biel, Franz Hofmann, Michalakis Stylianos, Hofmann Franz, Zong, Xiangang, Verena Hammelmann, Hammelmann, V;Zong, X;Hofmann, F;Michalakis, S;Biel, M   +15 more
core   +2 more sources