Artificial modulation of the gating behavior of a K+ channel in a KvAP-DNA chimera. [PDF]
PLoS ONE, 2011 We present experiments where the gating behavior of a voltage-gated ion channel is modulated by artificial ligand binding. We construct a channel-DNA chimera with the KvAP potassium channel reconstituted in an artificial membrane.
Andrew Wang, Giovanni Zocchi
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Voltage-dependent gating in a "voltage sensor-less" ion channel. [PDF]
PLoS Biology, 2010 The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity.
Harley T Kurata +4 more
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Trafficking and Gating Cooperation Between Deficient Nav1.5-mutant Channels to Rescue INa
Frontiers in Bioscience-Landmark, 2022 Background: Pathogenic variants in SCN5A, the gene encoding the cardiac Na+ channel α-subunit Nav1.5, result in life-threatening arrhythmias, e.g., Brugada syndrome, cardiac conduction defects and long QT syndrome. This variety of phenotypes is underlied
Jérôme Clatot +4 more
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Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel
Nature Communications, 2023 Human Eag2 is a voltage-gated potassium channel with unique delayed rectifying gating kinetics. Here, authors show how voltage opens the channel and illuminate a mechanism of delayed rectifier gating.
Mingfeng Zhang +2 more
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Cell Reports, 2023 Summary: The mechanoelectrical transduction (MET) channel of cochlear hair cells is gated by the tip link, but the mechanisms that establish the exquisite force sensitivity of this MET channel are not known.
Xufeng Qiu +4 more
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Theoretical implication of liganding reactions in axonal sodium channel gating [PDF]
, 1980 Dorogi PL, Neumann E. Theoretical implication of liganding reactions in axonal sodium channel gating. Neurochemistry International. 1980;2:45-51.Mathematical simulation models for measured permeability properties of axonal Na+ channels point to the ...
Dorogi, Peter L., Neumann, Eberhard
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The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage : gating at the cytoplasmic mouth [PDF]
, 2009 Although the tandem pore potassium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of extracellular pH, it is currently unknown whether the channel also shows gating at its inner, cytoplasmic mouth through ...
Feng, J. F. +23 more
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Flexibility of the N-Terminal mVDAC1 Segment Controls the Channel’s Gating Behavior [PDF]
, 2012 Since the solution of the molecular structures of members of the voltage dependent anion channels (VDACs), the N-terminal α-helix has been the main focus of attention, since its strategic location, in combination with its putative conformational ...
Grosse, Wolfgang +23 more
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Glutathione accelerates sodium channel inactivation in excised rat axonal membrane patches [PDF]
, 1992 The effects of glutathione were studied on the gating behaviour of sodium channels in membrane patches of rat axons. Depolarizing pulses from –120 to –40 mV elicited sodium currents of up to 500 pA, indicating the simultaneous activation of up to 250 ...
Quasthoff, Stefan +3 more
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Conformational changes in the catalytically inactive nucleotide-binding site of CFTR. [PDF]
, 2013 A central step in the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the association of its two cytosolic nucleotide-binding domains (NBDs) into a head-to-tail dimer, with two nucleotides bound at the ...
Mihályi Csaba +19 more
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