Results 1 to 10 of about 84,935 (163)
Fifty years of gating currents and channel gating [PDF]
Journal of General Physiology, 2023 We celebrate this year the 50th anniversary of the first electrophysiological recordings of the gating currents from voltage-dependent ion channels done in 1973. This retrospective tries to illustrate the context knowledge on channel gating and the impact gating-current recording had then, and how it continued to clarify concepts, elaborate new ideas ...
Fabio Franciolini +2 more
exaly +5 more sources
Mechanosensitive channel gating by delipidation. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Proteins embedded in membranes experience anisotropic forces from their surroundings. Mechanosensors are activated upon changes in the membrane tension and are the basis of important biological functionalities. However, the molecular mechanisms of mechanosensation are only vaguely understood.
Flegler VJ +14 more
europepmc +4 more sources
Activation gating in HCN2 channels. [PDF]
PLoS Computational Biology, 2018 Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels control electrical rhythmicity in specialized brain and heart cells. We quantitatively analysed voltage-dependent activation of homotetrameric HCN2 channels and its modulation by the ...
Sabine Hummert +5 more
doaj +4 more sources
Dual role of the S5 segment in type 1 ryanodine receptor channel gating [PDF]
Communications BiologyThe type 1 ryanodine receptor (RyR1) is a Ca2+ release channel in the sarcoplasmic reticulum that is essential for skeletal muscle contraction. RyR1 forms a channel with six transmembrane segments, in which S5 is the fifth segment and is thought to ...
Takashi Murayama +6 more
doaj +2 more sources
Biochimica Et Biophysica Acta - Biomembranes, 2004 Over the last two decades, the view of gap junction (GJ) channel gating has changed from one with GJs having a single transjunctional voltage-sensitive (V(j)-sensitive) gating mechanism to one with each hemichannel of a formed GJ channel, as well as unapposed hemichannels, containing two, molecularly distinct gating mechanisms.
Vytas Verselis, Feliksas Bukauskas
exaly +3 more sources
Molecular mechanism of GIRK2 channel gating modulated by cholesteryl hemisuccinate [PDF]
Frontiers in PhysiologyCholesterol, an essential lipid of cell membranes, regulates G protein-gated inwardly rectifying potassium (GIRK) channel activity. Previous studies have shown that cholesterol activates GIRK2 homotetrameric channels, which are expressed in dopaminergic ...
Meng Cui +8 more
doaj +2 more sources
Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor
eLife, 2021 Whether ion channel gating is independent of ion permeation has been an enduring, unresolved question. Here, applying single channel recording to the archetypal muscle nicotinic receptor, we unmask coupling between channel gating and ion permeation by ...
John R Strikwerda, Steven M Sine
doaj +1 more source
The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels. [PDF]
PLoS ONE, 2012 The voltage-gated K(+) (Kv) channel subunit Kv6.4 does not form functional homotetrameric channels but co-assembles with Kv2.1 to form functional Kv2.1/Kv6.4 heterotetrameric channels.
Elke Bocksteins +3 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The rapidly activating delayed rectifier K+ current generated by the cardiac hERG potassium channel encoded by KCNH2 is the most important reserve current for cardiac repolarization.
Zheng Zequn, Lian Jiangfang
doaj +1 more source
A new polymodal gating model of the proton-activated chloride channel.
PLoS Biology, 2023 The proton-activated chloride (PAC) channel plays critical roles in ischemic neuron death, but its activation mechanisms remain elusive. Here, we investigated the gating of PAC channels using its novel bifunctional modulator C77304.
Piao Zhao +13 more
doaj +1 more source