Results 1 to 10 of about 1,383,477 (261)

A new polymodal gating model of the proton-activated chloride channel.

PLoS Biology, 2023
The proton-activated chloride (PAC) channel plays critical roles in ischemic neuron death, but its activation mechanisms remain elusive. Here, we investigated the gating of PAC channels using its novel bifunctional modulator C77304.
Piao Zhao, Cheng Tang, Yuqin Yang, Zhen Xiao, Samantha Perez-Miller, Heng Zhang, Guoqing Luo, Hao Liu, Yaqi Li, Qingyi Liao, Fan Yang, Hao Dong, Rajesh Khanna, Zhonghua Liu   +13 more
doaj   +2 more sources

Dual role of the S5 segment in type 1 ryanodine receptor channel gating [PDF]

Communications Biology
The type 1 ryanodine receptor (RyR1) is a Ca2+ release channel in the sarcoplasmic reticulum that is essential for skeletal muscle contraction. RyR1 forms a channel with six transmembrane segments, in which S5 is the fifth segment and is thought to ...
Takashi Murayama, Yuya Otori, Nagomi Kurebayashi, Toshiko Yamazawa, Hideto Oyamada, Takashi Sakurai, Haruo Ogawa   +6 more
doaj   +2 more sources

Molecular mechanism of GIRK2 channel gating modulated by cholesteryl hemisuccinate [PDF]

Frontiers in Physiology
Cholesterol, an essential lipid of cell membranes, regulates G protein-gated inwardly rectifying potassium (GIRK) channel activity. Previous studies have shown that cholesterol activates GIRK2 homotetrameric channels, which are expressed in dopaminergic ...
Meng Cui, Meng Cui, Yongcheng Lu, Xinyi Ma, Diomedes E. Logothetis, Diomedes E. Logothetis, Diomedes E. Logothetis, Diomedes E. Logothetis, Diomedes E. Logothetis   +8 more
doaj   +2 more sources

Fifty Years of Gating Currents and Channel Gating [PDF]

Journal of General Physiology, 2023
Fabio FRANCIOLINI, Luigi Catacuzzeno, Franco Conti   +2 more
exaly   +2 more sources

Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor

eLife, 2021
Whether ion channel gating is independent of ion permeation has been an enduring, unresolved question. Here, applying single channel recording to the archetypal muscle nicotinic receptor, we unmask coupling between channel gating and ion permeation by ...
John R Strikwerda, Steven M Sine
doaj   +1 more source

The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels. [PDF]

PLoS ONE, 2012
The voltage-gated K(+) (Kv) channel subunit Kv6.4 does not form functional homotetrameric channels but co-assembles with Kv2.1 to form functional Kv2.1/Kv6.4 heterotetrameric channels.
Elke Bocksteins, Alain J Labro, Dirk J Snyders, Durga P Mohapatra   +3 more
doaj   +1 more source

Molecular Insights Into the Gating Kinetics of the Cardiac hERG Channel, Illuminated by Structure and Molecular Dynamics

Frontiers in Pharmacology, 2021
The rapidly activating delayed rectifier K+ current generated by the cardiac hERG potassium channel encoded by KCNH2 is the most important reserve current for cardiac repolarization.
Zheng Zequn, Lian Jiangfang
doaj   +1 more source

Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel

Nature Communications, 2022
Visualizing conformational changes during ion channel gating is crucial to understand their regulation. Here, Gao et al. capture multiple gating intermediates in a CNG channel as well as subtle, lateral voltage sensor movements necessary for channel ...
Xiaolong Gao, Philipp A. M. Schmidpeter, Vladimir Berka, Ryan J. Durham, Chen Fan, Vasanthi Jayaraman, Crina M. Nimigean   +6 more
doaj   +1 more source

Interplay between Gating and Block of Ligand-Gated Ion Channels

Brain Sciences, 2020
Drugs that inhibit ion channel function by binding in the channel and preventing current flow, known as channel blockers, can be used as powerful tools for analysis of channel properties.
Matthew B. Phillips, Aparna Nigam, Jon W. Johnson   +2 more
doaj   +1 more source

Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit. [PDF]

PLoS ONE, 2013
In the pentameric ligand-gated ion channel family, transmitter binds in the extracellular domain and conformational changes result in channel opening in the transmembrane domain.
Gustav Akk, Megan Eaton, Ping Li, Steven Zheng, Joshua Lo, Joe Henry Steinbach   +5 more
doaj   +1 more source