Results 121 to 130 of about 2,441,926 (254)

A Pharmacological Chaperone Therapy for Acute Intermittent Porphyria. [PDF]

Mol Ther, 2020
Bustad HJ, Toska K, Schmitt C, Vorland M, Skjærven L, Kallio JP, Simonin S, Letteron P, Underhaug J, Sandberg S, Martinez A.   +10 more
europepmc   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Pharmacological Inhibition of Hsp70 to Degrade c-FLIP: A Novel Indirect Approach for Cancer Therapy: A Narrative Review

Kurdistan Journal of Applied Research
The cellular FLICE-inhibitory protein (c-FLIP) is a master regulator of pro-grammed cell death, functioning as a key suppressor of extrinsic apoptosis mediated by death receptor signaling. Its persistent overexpression is a hall-mark of numerous cancers,
Azal Hamoody Jumaa, Sadeq Jaafer Al-Tameemi, Muthanna Atia Sabah, Youssef Shakuri Yasin   +3 more
doaj   +1 more source

A Systematic Review of Randomized Controlled Studies of Art Therapy

, 2014
This review article examines current knowledge about the efficacy of art therapy based on the findings of 8 randomized controlled trials (RCTs) conducted with adult populations from 2008-2013 that met a high standard of rigor.
Maujean, A, Pepping, Chris, Pepping, CA, Maujean, Annick, Kendall, Elizabeth, Kendall, E   +5 more
core   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Assessment of Gene Variant Amenability for Pharmacological Chaperone Therapy with 1-Deoxygalactonojirimycin in Fabry Disease. [PDF]

Int J Mol Sci, 2020
Lukas J, Cimmaruta C, Liguori L, Pantoom S, Iwanov K, Petters J, Hund C, Bunschkowski M, Hermann A, Cubellis MV, Rolfs A.   +10 more
europepmc   +1 more source

OT outlook (Online); OT newsletter

, 2001
Electronic coverage as of Dec. 30, 2003: Vol. 1, no. 1 (spring 2001)-; Description based on: Vol. 2, issue 1 (winter 2003); title from caption (viewed Dec.
Ohio Occupational Therapy, Physical Therapy, and Athletic Trainers Board. Occupational Therapy Section.
core  

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Microglia-derived nanovesicles synchronize macroautophagy and chaperone-mediated autophagy for Alzheimer’s disease therapy

Signal Transduction and Targeted Therapy
Dysregulated autophagy is a hallmark of Alzheimer’s disease (AD), yet the extent of impairment in macroautophagy and chaperone-mediated autophagy (CMA) remains unclear.
Min Li, Shuang Chen, Rong Guo, Yang Wang, Mingrui Yang, Yingke Liu, Qiang Zhang, Shiyu Zhu, Jiaxin Li, Fang Chen, Bo Wang, Man Li, Qin He   +12 more
doaj   +1 more source

Therapeutic landscape of Fabry disease: advances and challenges from classical strategies to emerging therapies

Frontiers in Medicine
Fabry disease (FD), as an X-linked lysosomal storage disorder (LSD), has seen significantly improved in patient prognosis since enzyme replacement therapy (ERT) was applied clinically in 2001. However, ERT has drawbacks such as immunogenicity, individual
Miao Zhang, Miao Zhang, Chendan Wang, Chendan Wang, Chendan Wang   +4 more
doaj   +1 more source