Results 11 to 20 of about 2,441,926 (254)
Pre-clinical Mouse Models of Neurodegenerative Lysosomal Storage Diseases
Frontiers in Molecular Biosciences, 2020 There are over 50 lysosomal hydrolase deficiencies, many of which cause neurodegeneration, cognitive decline and death. In recent years, a number of broad innovative therapies have been proposed and investigated for lysosomal storage diseases (LSDs ...
Jacob M. Favret +3 more
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Nature Communications, 2023 Cancer cells alter the expression levels of metabolic enzymes to fuel proliferation. The mitochondrion is a central hub of metabolic reprogramming, where chaperones service hundreds of clients, forming chaperone-client interaction networks.
Geut Galai +3 more
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Nature Communications, 2023 Molecular chaperone HSP70s are attractive targets for cancer therapy, but their substrate broadness and functional non-specificity have limited their role in therapeutical success.
Yaping Huang +5 more
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Combined Cytotoxic Effect of Inhibitors of Proteostasis on Human Colon Cancer Cells
Pharmaceuticals, 2022 Despite significant progress in the diagnosis and treatment of colorectal cancer, drug resistance continues to be a major limitation of therapy. In this regard, studies aimed at creating combination therapy are gaining popularity.
Alina D. Nikotina +11 more
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Frontiers in Cardiovascular Medicine, 2023 AimsCardiomyopathy in Fabry disease (FD) is a major determinant of morbidity and mortality. This study investigates the effects of FD-specific treatment using enzyme replacement therapy (ERT) and chaperone therapy on left atrial (LA) function using two ...
Christian Pogoda +7 more
doaj +1 more source
Therapeutic Strategies For Tay-Sachs Disease
Frontiers in Pharmacology, 2022 Tay-Sachs disease (TSD) is an autosomal recessive disease that features progressive neurodegenerative presentations. It affects one in 100,000 live births. Currently, there is no approved therapy or cure.
Jaqueline A. Picache +2 more
doaj +1 more source
PERANAN DUKUNGAN PENDAMPING DAN KEBIASAAN MAKAN PASIEN KANKER SELAMA MENJALANI TERAPI
Media Gizi Indonesia, 2017 Cancer patients had a decrease in appetite which leads to weight loss and nutritional status due to the cancer itself or the side effect of therapy. The existence of family support as a chaperone has an important role in the nutritional fulfillment of ...
Stefana Danty Putri Caesandri +1 more
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Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycD in complex with a peptide of the minor translocator YopD [PDF]
, 2012 Schreiner M, Niemann H. Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycD in complex with a peptide of the minor translocator YopD. BMC Structural Biology. 2012;12(1): 13.Background Type III secretion systems are used by
Niemann, H.H. +5 more
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Current and Investigational Therapeutics for Fabry Disease
Kidney International Reports, 2020 Fabry disease (FD) is an X-linked lysosomal storage disease caused by a deficiency in the lysosomal enzyme α-galactosidase (α-GAL). This in turn leads to the buildup of globotriaosylceramide, resulting classically in progressive kidney disease ...
Andrew Felis +4 more
doaj +1 more source
The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity [PDF]
, 2012 Overexpression or mutation of alpha-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function.
Butler, Erin K. +41 more
core +2 more sources