Results 21 to 30 of about 2,441,926 (254)
“Metacognitive Reflection and Insight Therapy” (MERIT) for the Occupational Therapy Practitioner [PDF]
, 2022 Background: Metacognitive Reflection and Insight Therapy (MERIT) is a manualized, evidence-based approach that supports occupational participation through its focus on the inter-related constructs of meaning making, positionality, and self-definition ...
Lysaker, Paul H. +3 more
core +1 more source
The Human TPR Protein TTC4 Is a Putative Hsp90 Co-Chaperone Which Interacts with CDC6 and Shows Alterations in Transformed Cells. [PDF]
, 2008 BACKGROUND: The human TTC4 protein is a TPR (tetratricopeptide repeat) motif-containing protein. The gene was originally identified as being localized in a genomic region linked to breast cancer and subsequent studies on melanoma cell lines revealed ...
Bennett, D +8 more
core +2 more sources
Pharmaceuticals, 2023 Alzheimer’s disease (AD) is the most common type of dementia and is listed as the sixth-leading cause of death in the United States. Recent findings have linked AD to the aggregation of amyloid beta peptides (Aβ), a proteolytic fragment of 39–43 amino ...
David Sanchez-Rodriguez +2 more
doaj +1 more source
Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones [PDF]
, 2010 Pseudomonas aeruginosa, an important human pathogen, is estimated to be responsible for,10% of nosocomial infections worldwide. The pathogenesis of P. aeruginosa starts from its colonization in the damaged tissue or medical devices (e. g.
Filloux, A. +23 more
core +1 more source
Pharmaceutics, 2023 Mucopolysaccharidoses (MPS) are rare genetic disorders belonging to the lysosomal storage diseases. They are caused by mutations in genes encoding lysosomal enzymes responsible for degrading glycosaminoglycans (GAGs).
Magdalena Żabińska +7 more
doaj +1 more source
The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation [PDF]
, 2011 Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant ...
Bowman, Andrew +16 more
core +1 more source
Chaperone/usher machinery [PDF]
, 2012 Many virulence organelles of Gram-negative bacterial pathogens are assembled via the periplasmic chaperone/usher (CU) pathway. The assembly process is a complex task, involving secretion of organelle subunits via the two membranes and periplasm, subunit ...
Yu, Xiaodi
core +1 more source
Wrapping the alpha-crystallin domain fold in a chaperone assembly [PDF]
, 2005 Small heat shock proteins (sHsps) are oligomers that perform a protective function by binding denatured proteins. Although ubiquitous, they are of variable sequence except for a C-terminal similar to 90-residue "alpha-crystallin domain".
Kappé, G. +9 more
core +2 more sources
Chaperone-mediated autophagy protects against hyperglycemic stress
, 2023 Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homeostasis and metabolism, and whose defects have been associated with several human pathologies.
Sara Balbuena-Pecino (13914297) +11 more
core +1 more source
Journal of Nanobiotechnology, 2022 Practice of tumor-targeted suicide gene therapy is hampered by unsafe and low efficient delivery of plasmid DNA (pDNA). Using HIV-Tat-derived peptide (Tat) to non-covalently form Tat/pDNA complexes advances the delivery performance.
Linjia Su +11 more
doaj +1 more source