Results 211 to 220 of about 2,441,926 (254)

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

TXNL1 in redox and protein quality control: mechanisms and disease relevance. [PDF]

Front Cell Dev Biol
Wu S, Li D, Xiao D.
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Heat shock proteins in male infertility: recent advances and clinical implications. [PDF]

Front Cell Dev Biol
Wu Z, Zhang W, Han R, Ping H, Xia L, Ding H, Yuan J, Wang X, Qin Q.   +8 more
europepmc   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source

HIRA loss is frequent but not universal in human fumarate hydratase-deficient renal cell carcinoma and defines divergent oncogenic programs. [PDF]

Biomark Res
Shi X, Tan Z, Sun G, Zeng H, Zhang X.
europepmc   +1 more source

The place bonding potential of nature‐based citizen science with refugee children and youth

People and Nature, EarlyView.
Abstract Nature‐based citizen science often involves close interaction with places. In addition to providing benefits, such as learning opportunities and contact with nature, it can facilitate and shape bonds between people and places. Research exploring the place bonding potential of such projects is still in its infancy. This paper addresses this gap
Ekaterina Egorova
wiley   +1 more source

Heat Shock Proteins as Targets for Cancer Therapeutics. [PDF]

J Clin Med
Trikala A, Shen B, Bhardwaj S.
europepmc   +1 more source

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

Nicotinamide Mononucleotide Adenylyltransferase 1 and NAD⁺ Homeostasis in Neuroprotection and Aging. [PDF]

Metabolites
Sun Y, Li B, Qian Z.
europepmc   +1 more source