Results 161 to 170 of about 184,458 (283)

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier, Lukas Griesinger, Matthias Franzreb, Simon Kluters   +3 more
wiley   +1 more source

A J-domain protein enhances memory by promoting physiological amyloid formation in <i>Drosophila</i>. [PDF]

Proc Natl Acad Sci U S A
Patton K, Yi Y, Burt R, Ng KK, Mukhi M, Khaki PSS, Hervas R, Si K.   +7 more
europepmc   +1 more source

Defining the interaction of the protease CpaA with its type II secretion chaperone CpaB and its contribution to virulence in Acinetobacter species [PDF]

, 2017
Feldman, Mario F., Kinsella, Rachel L., Lopez, Juvenal, Palmer, Lauren D., Salinas, Nichole D., Skaar, Eric P., Tolia, Niraj H.   +6 more
core   +2 more sources

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Distribution and evolutionary significance of the DnaK-DnaJ-GrpE (KJE) chaperone system in archaea. [PDF]

Cell Stress Chaperones
Rebeaud ME.
europepmc   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality. [PDF]

Nat Commun
Sitarik I, Vu QV, Petucci J, Frutos P, Song H, O'Brien EP.   +5 more
europepmc   +1 more source

HSP90 proteins in the scenario of tumor complexity [PDF]

, 2017
Rasola, Andrea
core   +1 more source

Targeting Hsp90 with cemdomespib reduces seizure burden and alters disease course in preclinical epilepsy models

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a chronic neurological disorder characterized by recurrent seizures and frequent cognitive and psychiatric comorbidities. Although current antiseizure medications provide symptomatic relief, they fail to prevent or modify epileptogenesis.
Yara Sheeni, Prince Kumar Singh, Sereen Sandouka, Taige Zhang, Alina Nemirovski, Aseel Saadi, Rhoda Olowe Taiwo, Matthew C. Walker, Tawfeeq Shekh‐Ahmad   +8 more
wiley   +1 more source

Metabolic functions for molecular chaperones and stress proteins in microcephaly. [PDF]

Cell Mol Life Sci
Morris MJ, Ng DCH.
europepmc   +1 more source