Results 161 to 170 of about 110,947 (209)
Assembly chaperones: a perspective
The historical origins and current interpretation of the molecular chaperone concept are presented, with the emphasis on the distinction between folding chaperones and assembly chaperones.
R John Ellis
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Nature Plants, 2019
Heat-shock protein 90 (HSP90) chaperones play an essential role in plant defence by assisting the folding of client proteins needed for immunity. A newly identified bacterial effector promotes disease by mimicking a HSP90 client, functioning as a minimal kinase that phosphorylates and inactivates the chaperone.
Huan, Chen +2 more
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Heat-shock protein 90 (HSP90) chaperones play an essential role in plant defence by assisting the folding of client proteins needed for immunity. A newly identified bacterial effector promotes disease by mimicking a HSP90 client, functioning as a minimal kinase that phosphorylates and inactivates the chaperone.
Huan, Chen +2 more
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Of chromoplasts and chaperones
Trends in Plant Science, 2007Chromoplasts are carotenoid-accumulating plastids found in many fruits and flowers. In a new paper, Li and colleagues show that the Or gene of cauliflower induces differentiation of beta-carotene-containing chromoplasts in the (normally non-pigmented) curd tissue.
Giovanni, Giuliano, Gianfranco, Diretto
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Seminars in Cell & Developmental Biology, 2000
We discuss nuclear chaperones that bind correctly folded protein subunits and mediate molecular interactions, particularly between proteins and nucleic acids. The charge of these chaperones helps to prevent non-specific electrostatic interactions between the components.
A, Philpott, T, Krude, R A, Laskey
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We discuss nuclear chaperones that bind correctly folded protein subunits and mediate molecular interactions, particularly between proteins and nucleic acids. The charge of these chaperones helps to prevent non-specific electrostatic interactions between the components.
A, Philpott, T, Krude, R A, Laskey
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Biogerontology, 2005
That evolution of longevity may depend on alterations in the expression of relatively few regulatory genes has been inferred from the rapid increase in lifespan during evolution of the hominid species (Cutler RG (1979) Mech Ageing Dev 9: 337-354). Also the inherent immortality of the embryonic stem cells implies that replicative senescence (Hayflick L (
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That evolution of longevity may depend on alterations in the expression of relatively few regulatory genes has been inferred from the rapid increase in lifespan during evolution of the hominid species (Cutler RG (1979) Mech Ageing Dev 9: 337-354). Also the inherent immortality of the embryonic stem cells implies that replicative senescence (Hayflick L (
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Molecular Chaperones: Panning for chaperone-binding peptides
Current Biology, 1994Experiments designed to define the substrate-binding preferences of the molecular chaperone BiP show that bound peptides are characterized by a heptameric motif with alternating hydrophobic residues.
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Ageing is a complex yet universal and inevitable degenerative process that results in a decline in the cellular capacity for repair and adaptation to external stresses. Therefore, maintaining the appropriate balance of the cellular proteome is crucial. In addition to the ubiquitin-proteasome and autophagy-lysosomal systems, molecular chaperones play a ...
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