Results 61 to 70 of about 183,487 (307)

Hepatic lipase maturation: a partial proteome of interacting factors

Journal of Lipid Research, 2009
Tandem affinity purification (TAP) has been used to isolate proteins that interact with human hepatic lipase (HL) during its maturation in Chinese hamster ovary cells.
Mark H. Doolittle, Osnat Ben-Zeev, Sara Bassilian, Julian P. Whitelegge, Miklós Péterfy, Howard Wong   +5 more
doaj   +1 more source

The proteostasis network and its decline in ageing

, 2019
Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Hartl, F., Hipp, M., Kasturi, P.
core   +1 more source

Hsp70 in mitochondrial biogenesis [PDF]

, 1994
The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non ...
A. Tzagoloff, A. Tzagoloff, A.J. Caplan, A.J. Caplan, B.D. Gambill, B.S. Glick, C.K. Suzuki, D. Ang, D. M. Cyr, D.M. Cyr, D.M. Cyr, D.M. Cyr, D.M. Cyr, D.P. Atencio, E. Ikeda, E. Kutejová, E.A. Craig, E.A. Craig, F.-U. Hartl, G.S.P. Groot, H.R.B. Pelham, J. Ostermann, J. Rassow, J.F. Dice, J.P. Hendrick, K. Liberek, L. Dyck van, M. Eilers, M. Kiebler, M. Schleyer, M.-J. Gething, M.Y. Cheng, N. Rowley, N. Wang, P. Borst, P. Terpstra, P.-J. Kang, R. A. Stuart, R.A. Stuart, R.A. Stuart, R.B. Deshaies, R.G. Hadikusumo, R.J. Nelson, R.P. Beckman, S. Lindquist, S. Rospert, S.T. Hwang, T. Langer, U.C. Manning-Krieg, W. Neupert, W. Neupert, W. Voos, W.J. Chirico, Z. Xia   +53 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Circuit architecture explains functional similarity of bacterial heat shock responses

, 2012
Heat shock response is a stress response to temperature changes and a consecutive increase in amounts of unfolded proteins. To restore homeostasis, cells upregulate chaperones facilitating protein folding by means of transcription factors (TF).
Ala Trusina, Gamer J, Lopez-Larrea C, Maaloe O, Masayo Inoue, Namiko Mitarai, Neidhardt F C, Wetzstein M   +7 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

The Role of HSPB8, a Component of the Chaperone-Assisted Selective Autophagy Machinery, in Cancer

Cells, 2021
The cellular response to cancer-induced stress is one of the major aspects regulating cancer development and progression. The Heat Shock Protein B8 (HSPB8) is a small chaperone involved in chaperone-assisted selective autophagy (CASA).
Riccardo Cristofani, Margherita Piccolella, Valeria Crippa, Barbara Tedesco, Marina Montagnani Marelli, Angelo Poletti, Roberta M. Moretti   +6 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Bordetella pertussis Toxin

Toxins, 2018
The Bordetella pertussis toxin (PT) is one important virulence factor causing the severe childhood disease whooping cough which still accounted for approximately 63,000 deaths worldwide in children in 2013.
Katharina Ernst, Nina Eberhardt, Ann-Katrin Mittler, Michael Sonnabend, Anna Anastasia, Simon Freisinger, Cordelia Schiene-Fischer, Miroslav Malešević, Holger Barth   +8 more
doaj   +1 more source