Results 71 to 80 of about 37,307 (249)

Functional characterization of chaperonin containing T-complex polypeptide-1 and its conserved and novel substrates in Arabidopsis

Journal of Experimental Botany, 2019
In plants, chaperonin containing T-complex polypeptide-1 is a chaperonin protein complex of eight subunits that participates in the folding of tubulins and the catalytic subunit of protein phosphatase 4.
Hee-Kyung Ahn, Joong-Tak Yoon, Ilyeong Choi, Sumin Kim, Ho-Seok Lee, H. Pai   +5 more
semanticscholar   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

Comparative Genomics and Pathogenicity Analysis of Two Bacterial Symbionts of Entomopathogenic Nematodes: The Role of the GroEL Protein in Virulence

Microorganisms, 2022
Bacteria of the genera Xenorhabdus and Photorhabdus are symbionts of entomopathogenic nematodes. Despite their close phylogenetic relationship, they show differences in their pathogenicity and virulence mechanisms in target insects.
Abraham Rivera-Ramírez, Rosalba Salgado-Morales, Alfredo Jiménez-Pérez, Rebeca Pérez-Martínez, Blanca Inés García-Gómez, Edgar Dantán-González   +5 more
doaj   +1 more source

Chaperonin of Group I: Oligomeric Spectrum and Biochemical and Biological Implications

Frontiers in Molecular Biosciences, 2018
Chaperonins play various physiological roles and can also be pathogenic. Elucidation of their structure, e.g., oligomeric status and post-translational modifications (PTM), is necessary to understand their functions and mechanisms of action in health and
S. Vilasi, D. Bulone, Celeste Caruso Bavisotto, C. Campanella, A. Marino Gammazza, P. L. San Biagio, F. Cappello, E. Conway de Macario, A. Macario   +8 more
semanticscholar   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Evolvability of Chaperonin Substrate Proteins [PDF]

, 2009
Molecular chaperones ensure that their substrate proteins reach the functional native state, and prevent their aggregation. Recently, an additional function was proposed for molecular chaperones: they serve as buffers (_capacitors_) for evolution by ...
Emanuele Raineri, Luis Serrano, Paolo Ribeca, Tobias Maier   +3 more
core   +1 more source

Ubiquitination‐Driven Reprogramming of Proteostasis in Metastasis

Advanced Science, EarlyView.
The DCAF12–TRiC/CCT axis is a key regulator of metastasis in cancer. By reprogramming proteostasis to ensure efficient protein folding, it drives progression through a dual mechanism: enhancing cancer cell motility and invasiveness while concurrently activating pro‐growth and survival pathways.
Dongping Wei, Jiayan Chen, Yaping Xu
wiley   +1 more source

Curcumin affects HSP60 folding activity and levels in neuroblastoma cells [PDF]

, 2020
The fundamental challenge in fighting cancer is the development of protective agents able to interfere with the classical pathways of malignant transformation, such as extracellular matrix remodeling, epithelial\u2013mesenchymal transition and ...
Campanella C., Cappello F., CARUSO BAVISOTTO C., Lo Cascio F., Marino Gammazza A., Mocciaro E., Pace A., Palumbo Piccionello A., Vergilio G., Vitale A.M.   +9 more
core   +2 more sources

The TRiC Chaperonin Controls Reovirus Replication through Outer-Capsid Folding

Nature Microbiology, 2018
Viruses are molecular machines sustained through a life cycle that requires replication within host cells. Throughout the infectious cycle, viral and cellular components interact to advance the multistep process required to produce progeny virions ...
J. J. Knowlton, J. J. Knowlton, I. Castro, Alison W. Ashbrook, D. Gestaut, Paula F. Zamora, Paula F. Zamora, Joshua A. Bauer, J. Forrest, J. Frydman, C. Risco, T. Dermody   +11 more
semanticscholar   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source