Results 81 to 90 of about 27,779 (210)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

A Comparative Study of Penicillin G Acylase Expression in Two Escherichia coli Strains: BL21 (DE3) and Arctic Express

Hayati Journal of Biosciences
The growing demand for semisynthetic beta-lactams has directed attention towards enzymes, specifically Penicillin G Acylases (PGAs), for their potential in synthesizing these antibiotics.
Kartika Sari Cendana, Sri Rezeki Wulandari, Gabriela Christy Sabbathini, Maria Ulfah, Dini Achnafani, Abinawanto, Sunni Sofiah Aniqah, Is Helianti, Niknik Nurhayati   +8 more
doaj   +1 more source

Directed transport as a mechanism for protein folding in vivo

, 2009
We propose a model for protein folding in vivo based on a Brownian-ratchet mechanism in the multidimensional energy landscape space. The device is able to produce directed transport taking advantage of the assumed intrinsic asymmetric properties of the ...
Alberts B., Bhutani N., Ellis R. J., Ernesto González-Candela, Kramer G., Lapanje S., Levinthal C., van Kampen N. G., Visscher K., Víctor Romero-Rochín   +9 more
core   +1 more source

Production of a recombinant form of early pregnancy factor that can prolong allogeneic skin graft survival time in rats [PDF]

, 2000
Early pregnancy factor (EPF), an extracellular chaperonin 10 homologue, has immunosuppressive and growth factor properties. In order to carry out more extensive studies on the in vivo characteristics of EPF, a recombinant form of the molecule has been ...
Cassady, A I, Cavanagh, A C, McKay, D A, Morton, H, Murphy, R M, Somodevilla-Torres, M J, Summers, Kim, Swanson, C E   +7 more
core   +1 more source

Clostridioides difficile‐Derived Extracellular Vesicles Induce Proinflammatory Responses in Macrophages

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Clostridioides difficile (CD) is a leading cause of antibiotic‐associated diarrhoea in both hospitalized and non‐hospitalized patients. This study explores the role of extracellular vesicles (EVs) derived from Clostridioides difficile strain 630 (CD630‐EVs), which released spherical EVs during in vitro culture, in modulating pro‐inflammatory ...
Fangfang Fan, Yu Zeng, Qianli Zhao, Tongxuan Su, Yining Shen, Wei Chen, Cen Jiang, Qi Ni, Yiyue Liu, Ru Fan, Danfeng Dong, Yibing Peng   +11 more
wiley   +1 more source

Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations. [PDF]

, 2011
Protein stability is widely recognized as a major evolutionary constraint. However, the relation between mutation-induced perturbations of protein stability and biological fitness has remained elusive.
Eugene Shakhnovich, Shimon Bershtein
core   +1 more source

Effects of confinement and crowding on folding of model proteins

, 2008
We perform molecular dynamics simulations for a simple coarse-grained model of crambin placed inside of a softly repulsive sphere of radius R. The confinement makes folding at the optimal temperature slower and affects the folding scenarios, but both ...
Baruah, Baukmketner, Cheung, Cieplak, Cieplak, Cieplak, Duroux, Ellis, Go, Hartl, Hoang, Honeycutt, Jewett, Kwiecinska, Luisi, M. Wojciechowski, Marek Cieplak, Matzke, Melo, Moilanen, Murtas, Rathore, Sulkowska, Sulkowska, Szymczak, Szymczak, Takagi   +26 more
core   +1 more source

Transcriptome profiling of grapevine seedless segregants during berry development reveals candidate genes associated with berry weight [PDF]

, 2016
Indexación: Web of Science; PubMedBackground Berry size is considered as one of the main selection criteria in table grape breeding programs. However, this is a quantitative and polygenic trait, and its genetic determination is still poorly understood ...
A Doligez, A Roberts, A Zamboni, AJ Bais, Alejandro Maass, Alex Di Genova, AM Almeida, AP Friend, Ariel Orellana, AS Negri, BG Coombe, BG Coombe, BG Coombe, BM Fischer, C Chen, C Conde, C Houel, C Pastore, C Pratt, C Sweetman, C Trapnell, CA Ledbetter, Claudia Muñoz-Espinoza, D Costenaro da Silva, D Lijavetzki, D Moreno, D Schenck, DH Lorenz, F Carrari, F Dyda, FG Silva da, FJ Pérez, G Fanizza, GR Cramer, I Debeaujon, J Correa, J Correa, J Guo, J Tello, J Xu, JA Cabezas, José Correa, JP Nitsch, K Chen, K Yang, KCH Amrine, L Bogrë, L Costantini, L Deluc, L Fernandez, M Barticevic, M Chakrabarti, M Fasoli, M González-Agüero, M Lu, M Rienth, M Salmaso, Mauricio González-Agüero, MB Ali, MC Palumbo, MJ Carmona, MJ Martínez-Esteso, MK Aradhya, N Mejía, N Mejía, N Schumann, N Wang, N Yokotani, NS Watson-Haigh, O Gudenschwager, O Jaillon, P Barba, P Langcake, P Neudecker, P Nicolas, Patricio Hinrichsen, R Core Team, R Ursem, Romina Silva, S Dal Santo, S Epskamp, S Guillaumie, S Lê, S Myles, S Taylor, S Zenoni, SBP Athauda, T Sekito, T Wei, X Chen, Z Du   +90 more
core   +3 more sources

Proteomic Profiling of Human Extracellular Vesicles Reveals Diagnostic Biomarkers for Colon Adenocarcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Proteomic profiling of tissue explant‐ and plasma‐derived extracellular vesicles identified colon adenocarcinoma‐associated and healthy‐associated EV proteins. A 10‐protein EV panel enabled highly sensitive blood‐based detection of colon adenocarcinoma, showed marked postoperative changes, and retained performance in an independent validation cohort ...
Yura Seo, Yoon Dae Han, Linda Bojmar, Kyung‐A Kim, Yurin Seo, Taeyul K. Kim, Suho Lee, Yeleem Kim, Hye Bin Choi, Yujin H. Lim, Chae Hyun Kim, Alexander Sandberg, Chuanwen Fan, Pernille Lauritzen, Henrik Molina, Christopher Peralta, Jacob B. Geri, Colin Burdette, Dai Hoon Han, Heon Yung Gee, Insuk Lee, Jeon‐Soo Shin, Hyunwook Kim, Leon Li, Gabriel C. Tobias, Inbal Wortzel, Sang Joon Shin, Hyo‐Il Jung, Min Goo Lee, Soonmyung Paik, Robert E. Schwartz, Joong Bae Ahn, David Lyden, Han Sang Kim   +33 more
wiley   +1 more source

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity [PDF]

, 2015
Assemblies of huntingtin (HTT) fragments with expanded polyglutamine (polyQ) tracts are a pathological hallmark of Huntington's disease (HD). The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity are ...
Andrade-Navarro, Miguel A., Bates, Gillian P., Boeddrich, Annett, Bounab, Yacine, Chaurasia, Gautam, Fournier, David, Friedrich, Ralf P., Futschik, Matthias E., Graham, Rona K., Haenig, Christian, Hayden, Michael R., Hesse, Franziska, Klockmeier, Konrad, Li, Shuang, Nicoletti, Cecilia, Priller, Josef, Riechers, Sean-Patrick, Russ, Jenny, Schnoegl, Sigrid, Sigrist, Stephan, Strempel, Nadine, Stroedicke, Martin, Wanker, Erich E., Wiglenda, Thomas, Yigit, Sargon   +24 more
core   +2 more sources