Results 101 to 110 of about 24,211 (206)

Proteomics Profiling of Chikungunya-Infected Aedes albopictus C6/36 Cells Reveal Important Mosquito Cell Factors in Virus Replication [PDF]

, 2015
10.1371/journal.pntd.0003544PLoS Neglected Tropical ...
Chu, Jang Hann, Lee, Regina Ching Hua
core   +3 more sources

Generation and plant production of recombinant fluorescent immunoglobulin G as innovative immunodiagnostic reagents

Plant Biotechnology Journal, Volume 24, Issue 1, Page 300-312, January 2026.
Summary Immunodiagnostic systems for on‐site screening are increasingly in demand but require expensive reagents such as chemically modified antibodies. To obtain biomolecules as ready‐to‐use reagents for diagnostics, new recombinant fluorescent immunoglobulins G were generated by fusion of the heavy chain of a monoclonal antibody, 5H3, to two ...
Ramona Sterpa, Marcello Catellani, Patrizia Melpignano, Thea Serra, Laura Anfossi, Cristina Capodicasa   +5 more
wiley   +1 more source

Potential contribution of Helicobacter pylori proteins in the pathogenesis of type 1 gastric neuroendocrine tumor and urticaria. In silico approach

PLoS ONE, 2023
Background Helicobacter pylori has been linked to several diseases such as chronic urticaria, gastritis, and type 1 gastric neuroendocrine tumors (type 1 gNET). Although these diseases seem to have different mechanisms, their relationship with H.
Andrés Sánchez Caraballo, Yenny Guzmán, Jorge Sánchez, Marlon Munera, Elizabeth Garcia, Deyanira Gonzalez-Devia   +5 more
doaj  

A human CCT5 gene mutation causing distal neuropathy impairs hexadecamer assembly in an archaeal model [PDF]

, 2014
Chaperonins mediate protein folding in a cavity formed by multisubunit rings. The human CCT has eight non-identical subunits and the His147Arg mutation in one subunit, CCT5, causes neuropathy.
ALMERICO, Anna Maria, Angileri, F, CAPPELLO, Francesco, de Macario, E, LAURIA, Antonino, Lednev, I, Luo, H, Macario, A, Min, W, Robb, F., Shanmugasundaram, M   +10 more
core   +1 more source

Sex differences in the physiological response to acute anterior cruciate ligament overuse

The Journal of Physiology, Volume 604, Issue 1, Page 297-316, 1 January 2026.
Abstract figure legend With equivalent in vivo fatigue loading of the anterior cruciate ligament (ACL), females accumulate more tissue damage and mount a slower reparative response than males, when the applied loads between sexes are equivalent. By contrast, males accumulate less tissue damage and mount a robust reparative response that includes ...
Stephen H. Schlecht, Benjamin E. Loflin, Adam R. Carter, Roufael Hanna, Simran Shergill, Edward M. Wojtys   +5 more
wiley   +1 more source

Potential prognostic value and immune landscape of lactylation and liquid–liquid phase separation related genes in acute myeloid leukemia

Hematology
Objectives Lactylation- and liquid-liquid phase separation-related differentially expressed genes (LLRDEGs) have been implicated in cancer. However, their role in acute myeloid leukemia (AML) remains largely unexplored.Methods LLRDEGs associated with AML
Tingxiu Jiang, Hong Chen, Chunjie Qin, Guoran Xie, Qiumei Huang, Shaomei Chen, Yongrong Lai   +6 more
doaj   +1 more source

TMEM106C, BSG, COPE, CDCA8, KPNA2, LIG1, UQCRH, and CCT5: Predictive of Survival and Immunotherapy Resistance in Hepatocellular Carcinoma

Human Mutation, Volume 2026, Issue 1, 2026.
Introduction Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide, with cellular senescence playing a context‐dependent role in tumor progression and the immunosuppressive microenvironment. This study is aimed at identifying senescence‐related gene signatures through integrated single‐cell and transcriptomic ...
Kai Yu, Minqi Chen, Wanchao Hou, Jinhua Lu, Qianhan Liu, Wanrong Zeng, Zhengcai Du, Xiaotao Hou, Erwei Hao, Jiagang Deng, Peipei Gong   +10 more
wiley   +1 more source

Chaperonopathies and Chaperonotherapy. Hsp60 as Therapeutic Target in Cancer: Potential Benefits and Risks. [PDF]

, 2013
In this minireview we focus on Hsp60 as a target for anticancer therapy. We discuss the new concepts of chaperonopathies and chaperonotherapy and present information on Hsp60 localization in the cell membrane of human tumor cells.
Angileri, Francesca, Cappello, F, Conway de Macario, E, Macario, AJL   +3 more
core   +1 more source

Senescent Fibroblasts Drive Melanoma Progression Through GCP‐2 Induced CREB Phosphorylation Enhancing Glycolysis

Aging Cell, Volume 24, Issue 12, December 2025.
Aging constitutes the largest risk factor for melanoma progression; the underlying reason is poorly understood. Here we show that the chemokine GCP‐2 is excessively released by senescent fibroblasts in vitro and in the skin of old melanoma patients. GCP‐2, via phosphorylation of the transcription factor CREB at serine 133, regulates cell cycle control ...
Abhijit Basu, Vida Farsam, Karmveer Singh, Diana Crisan, Nicolai Treiber, Lars Alexander Schneider, Margit Huber, Jennifer I. Engelmeyer, Björn Schumacher, Pallab Maity, Daniel Brandt, Martin Jastroch, Cornelia Mauch, Hartmut Geiger, Dimitris Kletsas, Karin Scharffetter‐Kochanek   +15 more
wiley   +1 more source

Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein

, 2020
The ATP-dependent Hsp70 chaperones (DnaK in E. coli) mediate protein folding in cooperation with J proteins and nucleotide exchange factors (E. coli DnaJ and GrpE, respectively). The Hsp70 system prevents protein aggregation and increases folding yields.
Balchin, D., Hartl, F., Hayer-Hartl, M., Imamoglu, R.   +3 more
core   +1 more source